The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Epidemiology of osteoporotic fracture in Moldova and development of a country specific FRAX model

Epidemiology of osteoporotic fracture in Moldova and development of a country specific FRAX model
Epidemiology of osteoporotic fracture in Moldova and development of a country specific FRAX model
Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment.
OBJECTIVE:
This paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX® tool.
METHODS:
We carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country's population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models.
RESULTS:
The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania).
CONCLUSION:
The FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment.
Epidemiology, FRAX, Fracture probability, Hip fracture
1862-3522
1-8
Zakroyeva, Alla
cd5a3017-965e-4182-89bd-2ff944350a3e
Lesnyak, O.
79b8479e-2590-4bc1-8fbe-1f5941edc13e
Cazac, Victor
fd78c9b4-54de-47a6-84df-a0948dcad57b
Groppa, Lillian
5b7387e3-9f4e-4f2d-8c77-aba2d7576b19
Russu, Eugen
6d1a4edc-2aca-4775-b70f-41e035e1f42b
Chrislari, Lia
6d58ad16-9912-4ac7-a661-45ae92b44db4
Rotaru, Larisa
b1d24de8-9b95-4de3-897c-a2612b95d9bf
Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
McCloskey, Eugene
3a2fac33-b400-4ae3-a212-04c3c3d2a517
Lorentzon, M.
11692e10-5916-4bb5-86c5-3ff9ccd77af6
Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d
Zakroyeva, Alla
cd5a3017-965e-4182-89bd-2ff944350a3e
Lesnyak, O.
79b8479e-2590-4bc1-8fbe-1f5941edc13e
Cazac, Victor
fd78c9b4-54de-47a6-84df-a0948dcad57b
Groppa, Lillian
5b7387e3-9f4e-4f2d-8c77-aba2d7576b19
Russu, Eugen
6d1a4edc-2aca-4775-b70f-41e035e1f42b
Chrislari, Lia
6d58ad16-9912-4ac7-a661-45ae92b44db4
Rotaru, Larisa
b1d24de8-9b95-4de3-897c-a2612b95d9bf
Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
McCloskey, Eugene
3a2fac33-b400-4ae3-a212-04c3c3d2a517
Lorentzon, M.
11692e10-5916-4bb5-86c5-3ff9ccd77af6
Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d

Zakroyeva, Alla, Lesnyak, O., Cazac, Victor, Groppa, Lillian, Russu, Eugen, Chrislari, Lia, Rotaru, Larisa, Johansson, Helena, Harvey, Nicholas, McCloskey, Eugene, Lorentzon, M. and Kanis, John A. (2020) Epidemiology of osteoporotic fracture in Moldova and development of a country specific FRAX model. Archives of Osteoporosis, 15 (1), 1-8, [13]. (doi:10.1007/s11657-019-0669-z).

Record type: Article

Abstract

Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment.
OBJECTIVE:
This paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX® tool.
METHODS:
We carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country's population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models.
RESULTS:
The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania).
CONCLUSION:
The FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment.

Text
MOLDOVA OSIN revision - Accepted Manuscript
Download (100kB)

More information

Accepted/In Press date: 4 November 2019
e-pub ahead of print date: 28 January 2020
Published date: 1 December 2020
Keywords: Epidemiology, FRAX, Fracture probability, Hip fracture

Identifiers

Local EPrints ID: 437611
URI: http://eprints.soton.ac.uk/id/eprint/437611
ISSN: 1862-3522
PURE UUID: 49b4665c-f5a2-434c-bd67-7e1e2ebc6232
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 06 Feb 2020 17:32
Last modified: 09 Jan 2022 03:15

Export record

Altmetrics

Contributors

Author: Alla Zakroyeva
Author: O. Lesnyak
Author: Victor Cazac
Author: Lillian Groppa
Author: Eugen Russu
Author: Lia Chrislari
Author: Larisa Rotaru
Author: Helena Johansson
Author: Nicholas Harvey ORCID iD
Author: Eugene McCloskey
Author: M. Lorentzon
Author: John A. Kanis

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×