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Maternal birth weight and BMI mediate the transgenerational effect of grandmaternal BMI on grandchild’s birth weight

Maternal birth weight and BMI mediate the transgenerational effect of grandmaternal BMI on grandchild’s birth weight
Maternal birth weight and BMI mediate the transgenerational effect of grandmaternal BMI on grandchild’s birth weight

Objective

The aims of this study are to examine the potential association between grandmaternal BMI and grandchild’s birth weight (BW) and whether maternal BW and BMI mediate this association.

Methods

Data of 209 grandmother-mother pairs and 355 grandchildren from the Isle of Wight birth cohort in the UK were analyzed using path analysis.

Results

An indirect effect of grandmaternal BMI on increasing grandchild’s BW was mediated by maternal BW and BMI at age 18 years (indirect effects: β = 2.3 g/unit increase in grandmaternal BMI via maternal BW and β = 4.4 g via maternal BMI; P = 0.04). These two mediating effects of maternal BW and BMI confounded one another. Grandmaternal smoking during pregnancy had an indirect effect on decreasing grandchild’s BW, dependent on maternal smoking during pregnancy and BW (indirect effects: β = −36.1 g compared with nonsmoking grandmothers via maternal smoking during pregnancy and β = −27.2 g via maternal BW; P = 0.005). Neither direct effect between grandmaternal BMI and grandchild’s BW nor that between grandmaternal smoking during pregnancy and grandchild’s BW was statistically significant.

Conclusions

Larger grandmaternal BMI indirectly increased grandchild’s BW via maternal BW and BMI. Grandmaternal smoking during pregnancy indirectly reduced grandchild’s BW via maternal smoking during pregnancy and BW.

1930-7381
647-654
Shen, Yan
b555514e-82c2-4871-b760-aeaceed9e4fd
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Jiang, Yu
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Mzayek, Fawaz
0e635b70-c9f4-4cb0-a334-c75bb401559c
Arshad, Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853
Shen, Yan
b555514e-82c2-4871-b760-aeaceed9e4fd
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Jiang, Yu
4fa0a27b-8c06-4988-832a-8f5fb3a3f1ec
Mzayek, Fawaz
0e635b70-c9f4-4cb0-a334-c75bb401559c
Arshad, Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853

Shen, Yan, Zhang, Hongmei, Jiang, Yu, Mzayek, Fawaz, Arshad, Hasan and Karmaus, Wilfried (2020) Maternal birth weight and BMI mediate the transgenerational effect of grandmaternal BMI on grandchild’s birth weight. Obesity, 28 (3), 647-654. (doi:10.1002/oby.22680).

Record type: Article

Abstract

Objective

The aims of this study are to examine the potential association between grandmaternal BMI and grandchild’s birth weight (BW) and whether maternal BW and BMI mediate this association.

Methods

Data of 209 grandmother-mother pairs and 355 grandchildren from the Isle of Wight birth cohort in the UK were analyzed using path analysis.

Results

An indirect effect of grandmaternal BMI on increasing grandchild’s BW was mediated by maternal BW and BMI at age 18 years (indirect effects: β = 2.3 g/unit increase in grandmaternal BMI via maternal BW and β = 4.4 g via maternal BMI; P = 0.04). These two mediating effects of maternal BW and BMI confounded one another. Grandmaternal smoking during pregnancy had an indirect effect on decreasing grandchild’s BW, dependent on maternal smoking during pregnancy and BW (indirect effects: β = −36.1 g compared with nonsmoking grandmothers via maternal smoking during pregnancy and β = −27.2 g via maternal BW; P = 0.005). Neither direct effect between grandmaternal BMI and grandchild’s BW nor that between grandmaternal smoking during pregnancy and grandchild’s BW was statistically significant.

Conclusions

Larger grandmaternal BMI indirectly increased grandchild’s BW via maternal BW and BMI. Grandmaternal smoking during pregnancy indirectly reduced grandchild’s BW via maternal smoking during pregnancy and BW.

Text
Shen Grandmaternal BMI and Birth Weight Main Document R2 - Accepted Manuscript
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More information

Accepted/In Press date: 26 September 2019
e-pub ahead of print date: 3 February 2020
Published date: March 2020

Identifiers

Local EPrints ID: 438024
URI: http://eprints.soton.ac.uk/id/eprint/438024
ISSN: 1930-7381
PURE UUID: 7ddedc1e-7971-4156-a3bd-d2f804182ad2

Catalogue record

Date deposited: 26 Feb 2020 17:31
Last modified: 26 Nov 2021 05:03

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Contributors

Author: Yan Shen
Author: Hongmei Zhang
Author: Yu Jiang
Author: Fawaz Mzayek
Author: Hasan Arshad
Author: Wilfried Karmaus

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