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Multiscale three-dimensional imaging of the placenta

Multiscale three-dimensional imaging of the placenta
Multiscale three-dimensional imaging of the placenta
Placental function involves multiple different processes which operate at different scales from centimetres to nanometres. Everything that the placenta does from mediating blood flow to gene expression, occurs within a three-dimensional anatomical framework. This review outlines how multiscale three-dimensional imaging approaches can provide insight into placental structure and function. Three-dimensional imaging approaches include microCT, confocal, super resolution, light-sheet, and serial block-face scanning electron microscopy. Used together, these approaches allow three-dimensional imaging of the placenta across the scales at which different processes occur. Three-dimensional imaging illustrates the spatial relationships between structures and visualises structures that are not clearly apparent in two-dimensions. Understanding the three-dimensional structure of the placenta enables exploration of the relationship between structure and function, including through the development of computational models based on realistic geometries. Three-dimensional imaging approaches will enhance our understanding of placental function in health and disease.
Confocal, Imaging, Light-sheet microscopy, Placenta, Serial block face scanning electron microscopy, microCt
0143-4004
55-60
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Pearson-Farr, Jennifer E.
e7da2e7c-e8e8-47d6-aca4-86b1a5b90653
Lewis, Rohan M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Pearson-Farr, Jennifer E.
e7da2e7c-e8e8-47d6-aca4-86b1a5b90653

Lewis, Rohan M. and Pearson-Farr, Jennifer E. (2020) Multiscale three-dimensional imaging of the placenta. Placenta, 102, 55-60. (doi:10.1016/j.placenta.2020.01.016).

Record type: Review

Abstract

Placental function involves multiple different processes which operate at different scales from centimetres to nanometres. Everything that the placenta does from mediating blood flow to gene expression, occurs within a three-dimensional anatomical framework. This review outlines how multiscale three-dimensional imaging approaches can provide insight into placental structure and function. Three-dimensional imaging approaches include microCT, confocal, super resolution, light-sheet, and serial block-face scanning electron microscopy. Used together, these approaches allow three-dimensional imaging of the placenta across the scales at which different processes occur. Three-dimensional imaging illustrates the spatial relationships between structures and visualises structures that are not clearly apparent in two-dimensions. Understanding the three-dimensional structure of the placenta enables exploration of the relationship between structure and function, including through the development of computational models based on realistic geometries. Three-dimensional imaging approaches will enhance our understanding of placental function in health and disease.

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Multiscale imaging review for resubmission - Accepted Manuscript
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More information

Accepted/In Press date: 31 January 2020
e-pub ahead of print date: 1 February 2020
Keywords: Confocal, Imaging, Light-sheet microscopy, Placenta, Serial block face scanning electron microscopy, microCt

Identifiers

Local EPrints ID: 438232
URI: http://eprints.soton.ac.uk/id/eprint/438232
ISSN: 0143-4004
PURE UUID: 07f0b594-89b3-46a7-9f32-581a474844d3
ORCID for Rohan M. Lewis: ORCID iD orcid.org/0000-0003-4044-9104

Catalogue record

Date deposited: 04 Mar 2020 17:31
Last modified: 26 Nov 2021 07:15

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Contributors

Author: Rohan M. Lewis ORCID iD
Author: Jennifer E. Pearson-Farr

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