Self-perceived fracture risk in the Global Longitudinal Study of Osteoporosis in Women: its correlates and relationship with bone microarchitecture
Self-perceived fracture risk in the Global Longitudinal Study of Osteoporosis in Women: its correlates and relationship with bone microarchitecture
The purpose of this study is to examine correlates of self-perceived fracture risk (SPR) and relationships between SPR and subsequent bone density and microarchitecture in the UK arm of the Global Longitudinal Study of Osteoporosis in Women. 3912 women completed baseline questionnaires detailing medical history and SPR; 492 underwent HRpQCT scans of the radius and tibia and DXA scans of total body, hip, femoral neck and lumbar spine a median of 7.5 years later. Correlates of SPR were examined and a cluster analysis of potential predictors of SPR performed. SPR in relation to HRpQCT and aBMD parameters was examined using linear regression with and without adjustment for anthropometric, demographic and lifestyle covariates. Mean (SD) baseline age was 69.0 (9.0) years; 56.6% reported a similar SPR; 28.6% lower SPR; 14.9% higher SPR compared to women of similar age. In mutually-adjusted analysis, higher SPR was associated (p < 0.05) with: lower physical activity and educational attainment; use of anti–osteoporosis medications (AOM) and calcium supplements; greater number of falls in the previous year; history of fracture since aged 45; family history of hip fracture; and increased comorbidity. Higher SPR, history of fracture, and use of AOM, calcium and vitamin D clustered together. Even after adjustments that included AOM use, higher SPR was associated with: lower radial trabecular volumetric density and number, and higher trabecular separation; lower tibial cortical area and trabecular volumetric density; and lower aBMD at the femoral neck. Despite greater AOM use, women with higher baseline SPR had poorer subsequent bone health.
DXA, Determinants, Epidemiology, Fracture risk assessment, HRpQCT, Osteoporosis, Self-perceived fracture risk
625-636
Litwic, Anna
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Westbury, Leo
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Carter, Sarah
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Ward, Kathryn
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Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
1 June 2020
Litwic, Anna
5faa3ead-e7d1-4b1a-aa2d-f79444fa11e9
Westbury, Leo
5ed45df3-3df7-4bf9-bbad-07b63cd4b281
Carter, Sarah
a5111bba-b67c-47ec-b74a-b0bcef477fe6
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Litwic, Anna, Westbury, Leo, Carter, Sarah, Ward, Kathryn, Cooper, Cyrus and Dennison, Elaine
(2020)
Self-perceived fracture risk in the Global Longitudinal Study of Osteoporosis in Women: its correlates and relationship with bone microarchitecture.
Calcified Tissue International, 106 (6), .
(doi:10.1007/s00223-020-00680-9).
Abstract
The purpose of this study is to examine correlates of self-perceived fracture risk (SPR) and relationships between SPR and subsequent bone density and microarchitecture in the UK arm of the Global Longitudinal Study of Osteoporosis in Women. 3912 women completed baseline questionnaires detailing medical history and SPR; 492 underwent HRpQCT scans of the radius and tibia and DXA scans of total body, hip, femoral neck and lumbar spine a median of 7.5 years later. Correlates of SPR were examined and a cluster analysis of potential predictors of SPR performed. SPR in relation to HRpQCT and aBMD parameters was examined using linear regression with and without adjustment for anthropometric, demographic and lifestyle covariates. Mean (SD) baseline age was 69.0 (9.0) years; 56.6% reported a similar SPR; 28.6% lower SPR; 14.9% higher SPR compared to women of similar age. In mutually-adjusted analysis, higher SPR was associated (p < 0.05) with: lower physical activity and educational attainment; use of anti–osteoporosis medications (AOM) and calcium supplements; greater number of falls in the previous year; history of fracture since aged 45; family history of hip fracture; and increased comorbidity. Higher SPR, history of fracture, and use of AOM, calcium and vitamin D clustered together. Even after adjustments that included AOM use, higher SPR was associated with: lower radial trabecular volumetric density and number, and higher trabecular separation; lower tibial cortical area and trabecular volumetric density; and lower aBMD at the femoral neck. Despite greater AOM use, women with higher baseline SPR had poorer subsequent bone health.
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Revised Correlates of SPR in GLOW (00000002)
- Accepted Manuscript
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Litwic2020_Article_Self-perceivedFractureRiskInTh
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More information
Accepted/In Press date: 21 February 2020
e-pub ahead of print date: 5 March 2020
Published date: 1 June 2020
Additional Information:
Funding Information:
Funding was supported by Arthritis Research UK [Grant No. 20380].
Publisher Copyright:
© 2020, The Author(s).
Keywords:
DXA, Determinants, Epidemiology, Fracture risk assessment, HRpQCT, Osteoporosis, Self-perceived fracture risk
Identifiers
Local EPrints ID: 438388
URI: http://eprints.soton.ac.uk/id/eprint/438388
ISSN: 0171-967X
PURE UUID: 132c928d-57df-4ccd-b05b-1a504e61e0e8
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Date deposited: 09 Mar 2020 17:30
Last modified: 18 Mar 2024 05:09
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Author:
Anna Litwic
Author:
Sarah Carter
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