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Drug delivery for traditional and emerging airway models

Drug delivery for traditional and emerging airway models
Drug delivery for traditional and emerging airway models
Respiratory diseases such as asthma and COPD have no cures and few new treatments. These diseases have an immutable mortality rate and impact millions of individuals worldwide. Respiratory drug development is time-consuming and costly, owing to the inability of existing models to replicate the complexity of human disease (static cell cultures and animal models). The problem is intensified through the way in which drugs are delivered to these models, which is not always representative of the human microenvironment, where different drug delivery methods (impaction, sedimentation and diffusion) target different regions of the lungs. This review describes current models of the human airways together with the range of different aerosol drug delivery methods (commercially available and in development) alongside emerging Organ on Chip technologies.
1-19
Karra, Nikita
8037beb7-98d3-40b2-9e02-51e4e917b3c0
Swindle, Emily
fe393c7a-a513-4de4-b02e-27369bd7e84f
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Karra, Nikita
8037beb7-98d3-40b2-9e02-51e4e917b3c0
Swindle, Emily
fe393c7a-a513-4de4-b02e-27369bd7e84f
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Karra, Nikita, Swindle, Emily and Morgan, Hywel (2020) Drug delivery for traditional and emerging airway models. Organs-on-a-Chip, 1-19, [100002]. (doi:10.1016/j.ooc.2020.100002).

Record type: Article

Abstract

Respiratory diseases such as asthma and COPD have no cures and few new treatments. These diseases have an immutable mortality rate and impact millions of individuals worldwide. Respiratory drug development is time-consuming and costly, owing to the inability of existing models to replicate the complexity of human disease (static cell cultures and animal models). The problem is intensified through the way in which drugs are delivered to these models, which is not always representative of the human microenvironment, where different drug delivery methods (impaction, sedimentation and diffusion) target different regions of the lungs. This review describes current models of the human airways together with the range of different aerosol drug delivery methods (commercially available and in development) alongside emerging Organ on Chip technologies.

Text
Drug delivery for traditional and emerging airway models - Accepted Manuscript
Restricted to Repository staff only until 26 February 2021.
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More information

Accepted/In Press date: 24 February 2020
e-pub ahead of print date: 26 February 2020

Identifiers

Local EPrints ID: 438429
URI: http://eprints.soton.ac.uk/id/eprint/438429
PURE UUID: 09271f39-d6b8-4838-a48c-4a7ef92f6335
ORCID for Nikita Karra: ORCID iD orcid.org/0000-0003-2250-7438
ORCID for Emily Swindle: ORCID iD orcid.org/0000-0003-3644-7747
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

Catalogue record

Date deposited: 10 Mar 2020 17:30
Last modified: 07 Oct 2020 07:50

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