The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Pregnancy-related bone mineral and microarchitecture changes in women aged 30-45 years

Pregnancy-related bone mineral and microarchitecture changes in women aged 30-45 years
Pregnancy-related bone mineral and microarchitecture changes in women aged 30-45 years
At birth the neonatal skeleton contains 20-30 g Ca, it is hypothesized maternal bone mineral may be mobilized to support fetal skeletal development, though evidence of pregnancy-induced mineral mobilization is limited. We recruited healthy pregnant (n = 53) and non-pregnant non-lactating (NPNL, n = 37) women aged 30-45 years (mean 35.4 ± 3.8 years) and obtained peripheral quantitative computed tomography (pQCT) and high-resolution pQCT (HR-pQCT) scans from the tibia and radius at 14-16 and 34-36 weeks pregnancy, with a similar scan interval for NPNL. Multiple linear regression models were used to assess group differences in change between baseline and follow-up; differences are expressed as standard deviation scores (SDS) ± SEM. Decreases in vBMD outcomes were found in both groups, however, pregnancy-related decreases for pQCT total and trabecular vBMD were - 0.65 ± 0.22 SDS and - 0.50 ± 0.23 SDS greater (p < 0.05). HR-pQCT total and cortical vBMD decreased compared to NPNL by -0.49 ± 0.24 SDS and - 0.67 ± 0.23 SDS respectively; trabecular vBMD decreased in both groups to a similar magnitude. Pregnancy-related changes in bone microarchitecture significantly exceeded NPNL change for trabecular number 0.47 ± 0.23 SDS, trabecular separation -0.54 ± 0.24 SDS, cortical thickness - 1.01 ± 0.21 SDS, and cortical perimeter 0.78 ± 0.23 SDS. At the proximal radius, cortical vBMD and endosteal circumference increased by 0.50 ± 0.23 SDS and 0.46 ± 0.23 SDS respectively compared to NPNL while cortical thickness decreased -0.50 ± 0.22 SDS. Pregnancy-related decreases in total and compartment-specific vBMD exceed age-related change at the distal tibia. Changes at the radius were only evident with pQCT at the cortical-rich proximal site and suggest endosteal resorption. Although the magnitude of these pregnancy-related changes in the appendicular skeleton are small, if they reflect global changes across the skeleton at large they may contribute substantially to the Ca requirements of the fetus. This article is protected by copyright. All rights reserved.
AGING, ANALYSIS/QUANTITATION OF BONE, BONE QCT/μCT, EPIDEMIOLOGY, GENERAL POPULATION STUDIES
0884-0431
1253-1262
Breasail, Micheal O
91913ba1-a694-4365-80f0-dc253cc025c2
Prentice, Ann
675810ad-8022-453c-b3a3-8afff0e1a920
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7
Breasail, Micheal O
91913ba1-a694-4365-80f0-dc253cc025c2
Prentice, Ann
675810ad-8022-453c-b3a3-8afff0e1a920
Ward, Kathryn
39bd4db1-c948-4e32-930e-7bec8deb54c7

Breasail, Micheal O, Prentice, Ann and Ward, Kathryn (2020) Pregnancy-related bone mineral and microarchitecture changes in women aged 30-45 years. Journal of Bone and Mineral Research, 35 (7), 1253-1262. (doi:10.1002/jbmr.3998).

Record type: Article

Abstract

At birth the neonatal skeleton contains 20-30 g Ca, it is hypothesized maternal bone mineral may be mobilized to support fetal skeletal development, though evidence of pregnancy-induced mineral mobilization is limited. We recruited healthy pregnant (n = 53) and non-pregnant non-lactating (NPNL, n = 37) women aged 30-45 years (mean 35.4 ± 3.8 years) and obtained peripheral quantitative computed tomography (pQCT) and high-resolution pQCT (HR-pQCT) scans from the tibia and radius at 14-16 and 34-36 weeks pregnancy, with a similar scan interval for NPNL. Multiple linear regression models were used to assess group differences in change between baseline and follow-up; differences are expressed as standard deviation scores (SDS) ± SEM. Decreases in vBMD outcomes were found in both groups, however, pregnancy-related decreases for pQCT total and trabecular vBMD were - 0.65 ± 0.22 SDS and - 0.50 ± 0.23 SDS greater (p < 0.05). HR-pQCT total and cortical vBMD decreased compared to NPNL by -0.49 ± 0.24 SDS and - 0.67 ± 0.23 SDS respectively; trabecular vBMD decreased in both groups to a similar magnitude. Pregnancy-related changes in bone microarchitecture significantly exceeded NPNL change for trabecular number 0.47 ± 0.23 SDS, trabecular separation -0.54 ± 0.24 SDS, cortical thickness - 1.01 ± 0.21 SDS, and cortical perimeter 0.78 ± 0.23 SDS. At the proximal radius, cortical vBMD and endosteal circumference increased by 0.50 ± 0.23 SDS and 0.46 ± 0.23 SDS respectively compared to NPNL while cortical thickness decreased -0.50 ± 0.22 SDS. Pregnancy-related decreases in total and compartment-specific vBMD exceed age-related change at the distal tibia. Changes at the radius were only evident with pQCT at the cortical-rich proximal site and suggest endosteal resorption. Although the magnitude of these pregnancy-related changes in the appendicular skeleton are small, if they reflect global changes across the skeleton at large they may contribute substantially to the Ca requirements of the fetus. This article is protected by copyright. All rights reserved.

Text
Pregnancy-related bone mineral and microarchitecture changes in women aged 30-45 years - Accepted Manuscript
Download (144kB)

More information

Accepted/In Press date: 13 February 2020
e-pub ahead of print date: 2 March 2020
Keywords: AGING, ANALYSIS/QUANTITATION OF BONE, BONE QCT/μCT, EPIDEMIOLOGY, GENERAL POPULATION STUDIES

Identifiers

Local EPrints ID: 438480
URI: http://eprints.soton.ac.uk/id/eprint/438480
ISSN: 0884-0431
PURE UUID: 6dda8014-7710-4a41-b11a-871ed1e760e0
ORCID for Kathryn Ward: ORCID iD orcid.org/0000-0001-7034-6750

Catalogue record

Date deposited: 11 Mar 2020 17:30
Last modified: 26 Nov 2021 07:16

Export record

Altmetrics

Contributors

Author: Micheal O Breasail
Author: Ann Prentice
Author: Kathryn Ward ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×