Epidemiology of hip fractures in Bulgaria: development of a country specific FRAX model
Epidemiology of hip fractures in Bulgaria: development of a country specific FRAX model
Abstract: Summary: A retrospective population-based survey was undertaken in a region of Bulgaria to determine the incidence of hip fracture. The estimated number of hip fractures nationwide for 2015 was 9322 and is predicted to increase to 11,398 in 2050. The hip fracture rates were used to create a FRAX model. Objective: To describe the epidemiology of hip fractures in Bulgaria, which was then used to develop the country-specific fracture prediction FRAX® tool. Methods: We carried out a retrospective population-based survey in Stara Zagora, Bulgaria, representing approximately 4.6% of the country’s population. We identified hip fractures occurring in 2015, 2016 and 2017 from hospital registers and primary care sources held by the regional health insurance agency. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Bulgaria. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results: The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 9322 and is predicted to increase to 11,398 in 2050. FRAX-based probabilities were higher in Bulgaria than those in Serbia or Romania, lower than those in Turkey and similar to those in Greece. Conclusion: The FRAX model should enhance accuracy of determining fracture probability among the Bulgarian population and help guide decisions about treatment.
Bulgaria, Epidemiology, FRAX, Fracture probability, Hip fracture
Kirilova, E.P.
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Johansson, H.
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Kirilov, N.
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Vladeva, S.
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Kolarov, Z.
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Liu, E.
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Lorentzon, M.
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Vandenput, L.
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Harvey, N.
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McCloskey, E.
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Kanis, J. A.
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27 February 2020
Kirilova, E.P.
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Johansson, H.
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Kirilov, N.
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Vladeva, S.
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Kolarov, Z.
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Liu, E.
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Lorentzon, M.
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Vandenput, L.
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Harvey, N.
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McCloskey, E.
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Kanis, J. A.
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Kirilova, E.P., Johansson, H., Kirilov, N., Vladeva, S., Kolarov, Z., Liu, E., Lorentzon, M., Vandenput, L., Harvey, N., McCloskey, E. and Kanis, J. A.
(2020)
Epidemiology of hip fractures in Bulgaria: development of a country specific FRAX model.
Archives of Osteoporosis, 15 (1), [28].
(doi:10.1007/s11657-020-0710-2).
Abstract
Abstract: Summary: A retrospective population-based survey was undertaken in a region of Bulgaria to determine the incidence of hip fracture. The estimated number of hip fractures nationwide for 2015 was 9322 and is predicted to increase to 11,398 in 2050. The hip fracture rates were used to create a FRAX model. Objective: To describe the epidemiology of hip fractures in Bulgaria, which was then used to develop the country-specific fracture prediction FRAX® tool. Methods: We carried out a retrospective population-based survey in Stara Zagora, Bulgaria, representing approximately 4.6% of the country’s population. We identified hip fractures occurring in 2015, 2016 and 2017 from hospital registers and primary care sources held by the regional health insurance agency. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Bulgaria. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results: The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 9322 and is predicted to increase to 11,398 in 2050. FRAX-based probabilities were higher in Bulgaria than those in Serbia or Romania, lower than those in Turkey and similar to those in Greece. Conclusion: The FRAX model should enhance accuracy of determining fracture probability among the Bulgarian population and help guide decisions about treatment.
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FRAX Bulgaria v2 OSIN
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Kirilova2020_Article_EpidemiologyOfHipFracturesInBu
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Accepted/In Press date: 29 December 2019
e-pub ahead of print date: 27 February 2020
Published date: 27 February 2020
Additional Information:
Funding Information:
E Kirilova, H Johansson, N Kirilov, S Vladeva, T Petranova, E Liu, L Vanderput and Z Kolarov declare that they have no competing interests. M Lorentzon has received lecture or consulting fees from Amgen, Lilly, UCB Pharma, Radius Health, Renapharma, Meda, GE-Lunar, Consilient Health and Tromp Medical. NC Harvey reports personal fees, consultancy, lecture fees and honoraria from Alliance for Better Bone Health, AMGEN, MSD, Eli Lilly, Servier, Shire, UCB, Kyowa Kirin, Consilient Healthcare, Radius Health and Internis Pharma outside the submitted work. EV McCloskey reports personal fees, consultancy, lecture fees, research support and/or honoraria from Amgen, AstraZeneca, Consilient Healthcare, Fresenius Kabi, GSK, Hologic, Internis, Lilly, Merck, Novartis, Pfizer, Roche, Sanofi-Aventis, Servier, Synexus, UCB, Warner Chilcott outside the submitted work. He also reports research support from Versus Arthritis, I3 Innovus, MRC and IOF outside the submitted work. JA Kanis reports grant support from Amgen, Lilly and Radius Health.
Publisher Copyright:
© 2020, The Author(s).
Keywords:
Bulgaria, Epidemiology, FRAX, Fracture probability, Hip fracture
Identifiers
Local EPrints ID: 438500
URI: http://eprints.soton.ac.uk/id/eprint/438500
ISSN: 1862-3522
PURE UUID: 56b99858-b5a9-4332-840a-b05df3753854
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Date deposited: 11 Mar 2020 17:32
Last modified: 17 Mar 2024 05:24
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Contributors
Author:
E.P. Kirilova
Author:
H. Johansson
Author:
N. Kirilov
Author:
S. Vladeva
Author:
Z. Kolarov
Author:
E. Liu
Author:
M. Lorentzon
Author:
L. Vandenput
Author:
E. McCloskey
Author:
J. A. Kanis
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