Does quality of life return to pre-treatment levels five years after curative intent surgery for colorectal cancer? Evidence from the ColoREctal Wellbeing (CREW) study
Does quality of life return to pre-treatment levels five years after curative intent surgery for colorectal cancer? Evidence from the ColoREctal Wellbeing (CREW) study
Background
The ColoREctal Wellbeing (CREW) study is the first study to prospectively recruit colorectal cancer (CRC) patients, carry out the baseline assessment pre-treatment and follow patients up over five years to delineate the impact of treatment on health and wellbeing.
Methods
CRC patients received questionnaires at baseline (pre-surgery), 3, 9, 15, 24, 36, 48 and 60 months. The primary outcome was Quality of Life in Adult Cancer Survivors (QLACS); self-efficacy, mental health, social support, affect, socio-demographics, clinical and treatment characteristics were also assessed. Representativeness was evaluated. Predictors at baseline and at 24 months of subsequent worsened quality of life (QOL) were identified using multivariable regression models.
Results
A representative cohort of 1017 non-metastatic CRC patients were recruited from 29 UK cancer centres. Around one third did not return to pre-surgery levels of QOL five years after treatment. Baseline factors associated with worsened QOL included >2 comorbidities, neoadjuvant treatment, high negative affect and low levels of self-efficacy, social support and positive affect. Predictors at 24 months included older age, low positive affect, high negative affect, fatigue and poor cognitive functioning.
Conclusions
Some risk factors for poor outcome up to five years following CRC surgery, such as self-efficacy, social support and comorbidity management, are amenable to change. Assessment of these factors from diagnosis to identify those most likely to need support in their recovery is warranted. Early intervention has the potential to improve outcomes.
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Wheelwright, Sally
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Permyakova, Natalia Vadimovna
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Calman, Lynn
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Din, Amy
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Fenlon, Deborah
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Richardson, Alison
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Sodergren, Samantha
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Smith, Peter W.F.
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Winter, Jane
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Foster, Claire
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9 April 2020
Wheelwright, Sally
2df90681-fb0a-4871-ae7d-75c88b35024b
Permyakova, Natalia Vadimovna
27793eb1-9b3d-4194-8e80-8d0d4c0798ea
Calman, Lynn
9ae254eb-74a7-4906-9eb4-62ad99f058c1
Din, Amy
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Fenlon, Deborah
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Richardson, Alison
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Sodergren, Samantha
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Smith, Peter W.F.
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Winter, Jane
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Foster, Claire
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Wheelwright, Sally, Permyakova, Natalia Vadimovna, Calman, Lynn, Din, Amy, Fenlon, Deborah, Richardson, Alison, Sodergren, Samantha, Smith, Peter W.F., Winter, Jane and Foster, Claire
(2020)
Does quality of life return to pre-treatment levels five years after curative intent surgery for colorectal cancer? Evidence from the ColoREctal Wellbeing (CREW) study.
PLoS ONE, 15 (4), , [e0231332].
(doi:10.1371/journal.pone.0231332).
Abstract
Background
The ColoREctal Wellbeing (CREW) study is the first study to prospectively recruit colorectal cancer (CRC) patients, carry out the baseline assessment pre-treatment and follow patients up over five years to delineate the impact of treatment on health and wellbeing.
Methods
CRC patients received questionnaires at baseline (pre-surgery), 3, 9, 15, 24, 36, 48 and 60 months. The primary outcome was Quality of Life in Adult Cancer Survivors (QLACS); self-efficacy, mental health, social support, affect, socio-demographics, clinical and treatment characteristics were also assessed. Representativeness was evaluated. Predictors at baseline and at 24 months of subsequent worsened quality of life (QOL) were identified using multivariable regression models.
Results
A representative cohort of 1017 non-metastatic CRC patients were recruited from 29 UK cancer centres. Around one third did not return to pre-surgery levels of QOL five years after treatment. Baseline factors associated with worsened QOL included >2 comorbidities, neoadjuvant treatment, high negative affect and low levels of self-efficacy, social support and positive affect. Predictors at 24 months included older age, low positive affect, high negative affect, fatigue and poor cognitive functioning.
Conclusions
Some risk factors for poor outcome up to five years following CRC surgery, such as self-efficacy, social support and comorbidity management, are amenable to change. Assessment of these factors from diagnosis to identify those most likely to need support in their recovery is warranted. Early intervention has the potential to improve outcomes.
Text
Does quality of life return to pre-treatment levels five years after curative intent surgery for colorectal cancer Evidence from the ColoREctal Wellbeing (CREW) study
- Accepted Manuscript
Text
journal.pone.0231332
- Version of Record
More information
Accepted/In Press date: 20 March 2020
e-pub ahead of print date: 9 April 2020
Published date: 9 April 2020
Identifiers
Local EPrints ID: 438998
URI: http://eprints.soton.ac.uk/id/eprint/438998
ISSN: 1932-6203
PURE UUID: d0bc9cb8-3178-4053-9ba5-cb15b6f07727
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Date deposited: 31 Mar 2020 16:31
Last modified: 06 Jun 2024 01:51
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Contributors
Author:
Natalia Vadimovna Permyakova
Author:
Amy Din
Author:
Deborah Fenlon
Author:
Jane Winter
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