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A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer's disease by reducing the inflammatory response and oxidative stress in the nerve cells

A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer's disease by reducing the inflammatory response and oxidative stress in the nerve cells
A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer's disease by reducing the inflammatory response and oxidative stress in the nerve cells
In this work, a novel two-dimensional coordination polymer was prepared via reaction of 4,4′-dipyridyl (4,4′-bipy) with Zn(NO3)2·6H2O and m-terphenyl pentacarboxylic acid (H5L) within water and DMA mixed solvent, and its chemical formula is [Zn2(HL)(4,4′-bipy)(H2O)](DMA) (1). Due to its good framework stability in water, complex 1 was studied as a catalyst for photocatalytic degradation of methylene blue (MB) in water under the ultraviolet light. Both of the remarkable efficiency and good catalytic stability could be achieved in the complex 1. Furthermore, to evaluate the treatment activity of the compound on the Alzheimer's disease (AD), AD mice model was established and treated with the compound. And then, AD mice brain tissues were weighted and the cognitive function of AD mice was determined. Then, the content of amyloid β peptides (Aβ) in the hippocampus was measured with western blot; the inflammatory cytokines TNF-α along with IL-1β within CSF was detected via ELISA detection kit; oxidative stress level within the cells of nerve was determined via ROS test kit. CCK-8 assay was performed to detect the toxicity of the compound on normal human cells.
Alzheimer's disease, Coordination polymer, Methylene blue degradation, Zn(II)-framework
5171-5180
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
Han, Ping
dd6cac9c-cf54-4de9-9ef0-5a6f87493161
Liu, Qiang
29e43153-6730-492b-8312-9e376e40f532
Xiu, Guangrun
4021f6f1-a380-4893-b78b-209f31ae80be
Xu, Shujun
158221f4-6a70-4225-8ea3-81d79cb75480
Chen, Teng
8399a9f3-1fb4-4db0-b565-fefe19543bea
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
Han, Ping
dd6cac9c-cf54-4de9-9ef0-5a6f87493161
Liu, Qiang
29e43153-6730-492b-8312-9e376e40f532
Xiu, Guangrun
4021f6f1-a380-4893-b78b-209f31ae80be
Xu, Shujun
158221f4-6a70-4225-8ea3-81d79cb75480
Chen, Teng
8399a9f3-1fb4-4db0-b565-fefe19543bea

Hou, Ruihua, Han, Ping, Liu, Qiang, Xiu, Guangrun, Xu, Shujun and Chen, Teng (2020) A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer's disease by reducing the inflammatory response and oxidative stress in the nerve cells. Arabian Journal of Chemistry, 13 (4), 5171-5180. (doi:10.1016/j.arabjc.2020.02.017).

Record type: Article

Abstract

In this work, a novel two-dimensional coordination polymer was prepared via reaction of 4,4′-dipyridyl (4,4′-bipy) with Zn(NO3)2·6H2O and m-terphenyl pentacarboxylic acid (H5L) within water and DMA mixed solvent, and its chemical formula is [Zn2(HL)(4,4′-bipy)(H2O)](DMA) (1). Due to its good framework stability in water, complex 1 was studied as a catalyst for photocatalytic degradation of methylene blue (MB) in water under the ultraviolet light. Both of the remarkable efficiency and good catalytic stability could be achieved in the complex 1. Furthermore, to evaluate the treatment activity of the compound on the Alzheimer's disease (AD), AD mice model was established and treated with the compound. And then, AD mice brain tissues were weighted and the cognitive function of AD mice was determined. Then, the content of amyloid β peptides (Aβ) in the hippocampus was measured with western blot; the inflammatory cytokines TNF-α along with IL-1β within CSF was detected via ELISA detection kit; oxidative stress level within the cells of nerve was determined via ROS test kit. CCK-8 assay was performed to detect the toxicity of the compound on normal human cells.

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Accepted/In Press date: 25 February 2020
e-pub ahead of print date: 4 March 2020
Published date: April 2020
Keywords: Alzheimer's disease, Coordination polymer, Methylene blue degradation, Zn(II)-framework

Identifiers

Local EPrints ID: 439508
URI: http://eprints.soton.ac.uk/id/eprint/439508
PURE UUID: 373f25fd-de16-4ac8-b915-8f20c054f382
ORCID for Ruihua Hou: ORCID iD orcid.org/0000-0001-6127-1478

Catalogue record

Date deposited: 24 Apr 2020 16:39
Last modified: 26 Nov 2021 02:52

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Contributors

Author: Ruihua Hou ORCID iD
Author: Ping Han
Author: Qiang Liu
Author: Guangrun Xiu
Author: Shujun Xu
Author: Teng Chen

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