A new Zn(II)-coordination polymer based on m-terphenyl pentacarboxylic acid ligand for photocatalytic methylene blue degradation and protective effect against Alzheimer's disease by reducing the inflammatory response and oxidative stress in the nerve cells

Abstract

In this work, a novel two-dimensional coordination polymer was prepared via reaction of 4,4′-dipyridyl (4,4′-bipy) with Zn(NO3)2·6H2O and m-terphenyl pentacarboxylic acid (H5L) within water and DMA mixed solvent, and its chemical formula is [Zn2(HL)(4,4′-bipy)(H2O)](DMA) (1). Due to its good framework stability in water, complex 1 was studied as a catalyst for photocatalytic degradation of methylene blue (MB) in water under the ultraviolet light. Both of the remarkable efficiency and good catalytic stability could be achieved in the complex 1. Furthermore, to evaluate the treatment activity of the compound on the Alzheimer's disease (AD), AD mice model was established and treated with the compound. And then, AD mice brain tissues were weighted and the cognitive function of AD mice was determined. Then, the content of amyloid β peptides (Aβ) in the hippocampus was measured with western blot; the inflammatory cytokines TNF-α along with IL-1β within CSF was detected via ELISA detection kit; oxidative stress level within the cells of nerve was determined via ROS test kit. CCK-8 assay was performed to detect the toxicity of the compound on normal human cells.

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ORCID for Ruihua Hou: orcid.org/0000-0001-6127-1478

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