The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The epidemiology of osteoporosis

The epidemiology of osteoporosis
The epidemiology of osteoporosis
Introduction

With a worldwide ageing population, the importance of the prevention and management of osteoporotic fragility fractures is increasing over time. In this review, we discuss in detail the epidemiology of fragility fractures, how this is shaped by pharmacological interventions and how novel screening programmes can reduce the clinical and economic burden of osteoporotic fractures.

Sources of data

PubMed and Google Scholar were searched using various combinations of the keywords ‘osteoporosis’, ‘epidemiology’, ‘fracture’, ‘screening’, `FRAX’ and ‘SCOOP’.

Areas of agreement

The economic burden of osteoporosis-related fracture is significant, costing approximately $17.9 and £4 billion per annum in the USA and UK.

Areas of controversy

Risk calculators such as the web-based FRAX® algorithm have enabled assessment of an individual’s fracture risk using clinical risk factors, with only partial consideration of bone mineral density (BMD).

Growing points

As with all new interventions, we await the results of long-term use of osteoporosis screening algorithms and how these can be refined and incorporated into clinical practice.

Areas timely for developing research

Despite advances in osteoporosis screening, a minority of men and women at high fracture risk worldwide receive treatment. The economic and societal burden caused by osteoporosis is a clear motivation for improving the screening and management of osteoporosis worldwide.
epidemiology, fracture, osteoporosis
0007-1420
105-117
Clynes, Michael
b860d3b7-12ee-42b8-8cd5-1e1abfccbee2
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Curtis, Elizabeth
12aba0c3-1e9e-49ef-a7e9-3247e649cdd6
Fuggle, Nicholas
9ab0c81a-ac67-41c4-8860-23e0fdb1a900
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Clynes, Michael
b860d3b7-12ee-42b8-8cd5-1e1abfccbee2
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Curtis, Elizabeth
12aba0c3-1e9e-49ef-a7e9-3247e649cdd6
Fuggle, Nicholas
9ab0c81a-ac67-41c4-8860-23e0fdb1a900
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6

Clynes, Michael, Harvey, Nicholas, Curtis, Elizabeth, Fuggle, Nicholas, Dennison, Elaine and Cooper, Cyrus (2020) The epidemiology of osteoporosis. British Medical Bulletin, 133 (1), 105-117. (doi:10.1093/bmb/ldaa005).

Record type: Article

Abstract

Introduction

With a worldwide ageing population, the importance of the prevention and management of osteoporotic fragility fractures is increasing over time. In this review, we discuss in detail the epidemiology of fragility fractures, how this is shaped by pharmacological interventions and how novel screening programmes can reduce the clinical and economic burden of osteoporotic fractures.

Sources of data

PubMed and Google Scholar were searched using various combinations of the keywords ‘osteoporosis’, ‘epidemiology’, ‘fracture’, ‘screening’, `FRAX’ and ‘SCOOP’.

Areas of agreement

The economic burden of osteoporosis-related fracture is significant, costing approximately $17.9 and £4 billion per annum in the USA and UK.

Areas of controversy

Risk calculators such as the web-based FRAX® algorithm have enabled assessment of an individual’s fracture risk using clinical risk factors, with only partial consideration of bone mineral density (BMD).

Growing points

As with all new interventions, we await the results of long-term use of osteoporosis screening algorithms and how these can be refined and incorporated into clinical practice.

Areas timely for developing research

Despite advances in osteoporosis screening, a minority of men and women at high fracture risk worldwide receive treatment. The economic and societal burden caused by osteoporosis is a clear motivation for improving the screening and management of osteoporosis worldwide.

Text
Osteoporosis Epidemiology BMB revised manuscript - Accepted Manuscript
Download (1MB)

More information

Accepted/In Press date: 28 February 2020
e-pub ahead of print date: 13 April 2020
Keywords: epidemiology, fracture, osteoporosis

Identifiers

Local EPrints ID: 439590
URI: http://eprints.soton.ac.uk/id/eprint/439590
ISSN: 0007-1420
PURE UUID: 24e31afd-c18c-430e-b536-5e3717367c53
ORCID for Michael Clynes: ORCID iD orcid.org/0000-0001-7597-7658
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Elizabeth Curtis: ORCID iD orcid.org/0000-0002-5147-0550
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 27 Apr 2020 16:47
Last modified: 26 Nov 2021 07:15

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×