The epidemiology of osteoporosis
The epidemiology of osteoporosis
Introduction
With a worldwide ageing population, the importance of the prevention and management of osteoporotic fragility fractures is increasing over time. In this review, we discuss in detail the epidemiology of fragility fractures, how this is shaped by pharmacological interventions and how novel screening programmes can reduce the clinical and economic burden of osteoporotic fractures.
Sources of data
PubMed and Google Scholar were searched using various combinations of the keywords ‘osteoporosis’, ‘epidemiology’, ‘fracture’, ‘screening’, `FRAX’ and ‘SCOOP’.
Areas of agreement
The economic burden of osteoporosis-related fracture is significant, costing approximately $17.9 and £4 billion per annum in the USA and UK.
Areas of controversy
Risk calculators such as the web-based FRAX® algorithm have enabled assessment of an individual’s fracture risk using clinical risk factors, with only partial consideration of bone mineral density (BMD).
Growing points
As with all new interventions, we await the results of long-term use of osteoporosis screening algorithms and how these can be refined and incorporated into clinical practice.
Areas timely for developing research
Despite advances in osteoporosis screening, a minority of men and women at high fracture risk worldwide receive treatment. The economic and societal burden caused by osteoporosis is a clear motivation for improving the screening and management of osteoporosis worldwide.
epidemiology, fracture, osteoporosis
105-117
Clynes, Michael
b860d3b7-12ee-42b8-8cd5-1e1abfccbee2
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Curtis, Elizabeth
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Fuggle, Nicholas
9ab0c81a-ac67-41c4-8860-23e0fdb1a900
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
13 April 2020
Clynes, Michael
b860d3b7-12ee-42b8-8cd5-1e1abfccbee2
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Curtis, Elizabeth
12aba0c3-1e9e-49ef-a7e9-3247e649cdd6
Fuggle, Nicholas
9ab0c81a-ac67-41c4-8860-23e0fdb1a900
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Clynes, Michael, Harvey, Nicholas, Curtis, Elizabeth, Fuggle, Nicholas, Dennison, Elaine and Cooper, Cyrus
(2020)
The epidemiology of osteoporosis.
British Medical Bulletin, 133 (1), .
(doi:10.1093/bmb/ldaa005).
Abstract
Introduction
With a worldwide ageing population, the importance of the prevention and management of osteoporotic fragility fractures is increasing over time. In this review, we discuss in detail the epidemiology of fragility fractures, how this is shaped by pharmacological interventions and how novel screening programmes can reduce the clinical and economic burden of osteoporotic fractures.
Sources of data
PubMed and Google Scholar were searched using various combinations of the keywords ‘osteoporosis’, ‘epidemiology’, ‘fracture’, ‘screening’, `FRAX’ and ‘SCOOP’.
Areas of agreement
The economic burden of osteoporosis-related fracture is significant, costing approximately $17.9 and £4 billion per annum in the USA and UK.
Areas of controversy
Risk calculators such as the web-based FRAX® algorithm have enabled assessment of an individual’s fracture risk using clinical risk factors, with only partial consideration of bone mineral density (BMD).
Growing points
As with all new interventions, we await the results of long-term use of osteoporosis screening algorithms and how these can be refined and incorporated into clinical practice.
Areas timely for developing research
Despite advances in osteoporosis screening, a minority of men and women at high fracture risk worldwide receive treatment. The economic and societal burden caused by osteoporosis is a clear motivation for improving the screening and management of osteoporosis worldwide.
Text
Osteoporosis Epidemiology BMB revised manuscript
- Accepted Manuscript
More information
Accepted/In Press date: 28 February 2020
e-pub ahead of print date: 13 April 2020
Published date: 13 April 2020
Additional Information:
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Keywords:
epidemiology, fracture, osteoporosis
Identifiers
Local EPrints ID: 439590
URI: http://eprints.soton.ac.uk/id/eprint/439590
ISSN: 0007-1420
PURE UUID: 24e31afd-c18c-430e-b536-5e3717367c53
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Date deposited: 27 Apr 2020 16:47
Last modified: 18 Mar 2024 05:08
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