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Maternal glycaemia during pregnancy and child carotid intima media thickness, pulse wave velocity and augmentation index

Maternal glycaemia during pregnancy and child carotid intima media thickness, pulse wave velocity and augmentation index
Maternal glycaemia during pregnancy and child carotid intima media thickness, pulse wave velocity and augmentation index
In women without diabetes, little is known about the consequences of hyperglycemia during pregnancy for the offspring’s cardiovascular structure and function.

Objective
To investigate the association of maternal glycemia during pregnancy with cardiovascular risk markers in their children in GUSTO, a Singaporean birth cohort study.

Methods
Around 26 weeks’ gestation, a 75 g oral glucose tolerance test was performed and fasting plasma glucose (FPG) and 2-hour postprandial plasma glucose (PPPG) concentrations were measured. Gestational diabetes mellitus (GDM) was defined using WHO 1999 diagnostic criteria. At 6 years of age, we measured the child’s carotid intima-media thickness (cIMT), carotid-femoral pulse wave velocity (cfPWV), aortic augmentation index (AIx), and blood pressure (BP). Association of maternal glycemia during pregnancy with cardiovascular risk markers in their children were analyzed using multiple linear and logistic regressions.

Results
Analysis were performed on 479 mother–child dyads. Higher maternal FPG was associated with higher cIMT and, in males, with a higher cfPWV in the offspring (adjusted β [CI 95%], cIMT: 0.08 per 10mm increase [0.02; 0.15], cfPWV: 0.36 m/s [0.01; 0.70]). Higher 2-hour PPPG was associated with higher cfPWV and AIx. Gestational diabetes mellitus was associated with higher AIx. No association was found between maternal glycemia and their offspring blood pressure.

Conclusions
among mothers without pre-existing diabetes, higher glycemia during pregnancy was associated with mild structural and functional vascular changes in their children at 6 years of age across a continuum. These results support the necessity to monitor maternal glycemia during pregnancy even in the absence of pre-existing diabetes or diagnosed GDM.
AIx, PWV, cIMT, children, maternal glycemia, pregnancy
0021-972X
1-10
Yuan, Wen Lun
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Lin, J.
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Kramer, Michael S.
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Godfrey, Keith
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Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Chong, Yap-Seng
492de658-aa9e-4b57-95bf-33109f4d2cc5
Shek, Lynette P.
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Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Eriksson, Johan G.
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Yap, Fabian
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Lee, Yung Seng
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Choo, Jonathan T.L.
ee1264f1-5c62-4639-a6d1-89d252097cd8
Ling, L.H.
9a1d477e-fb84-47dc-ae8e-71ffb862b1ce
Yuan, Wen Lun
bd1a80dc-c82a-4387-b754-72e30dd603a7
Lin, J.
760f41ba-f8d1-4759-928c-4ac6c379cf12
Kramer, Michael S.
8af13d8f-cdb6-4bfb-a37a-aac9bee0d0c3
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Chong, Yap-Seng
492de658-aa9e-4b57-95bf-33109f4d2cc5
Shek, Lynette P.
9a77403c-0e0c-4536-a5ad-628ce94b279a
Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
Yap, Fabian
22f6b954-31fc-4696-a52b-e985a424b95b
Lee, Yung Seng
0e28a8d6-3085-4086-9fa1-ac0684783bcf
Choo, Jonathan T.L.
ee1264f1-5c62-4639-a6d1-89d252097cd8
Ling, L.H.
9a1d477e-fb84-47dc-ae8e-71ffb862b1ce

Yuan, Wen Lun, Lin, J., Kramer, Michael S., Godfrey, Keith, Gluckman, Peter D., Chong, Yap-Seng, Shek, Lynette P., Tan, Kok Hian, Chan, Shiao-Yng, Eriksson, Johan G., Yap, Fabian, Lee, Yung Seng, Choo, Jonathan T.L. and Ling, L.H. (2020) Maternal glycaemia during pregnancy and child carotid intima media thickness, pulse wave velocity and augmentation index. Journal of Clinical Endocrinology & Metabolism, 105 (7), 1-10. (doi:10.1210/clinem/dgaa211).

Record type: Article

Abstract

In women without diabetes, little is known about the consequences of hyperglycemia during pregnancy for the offspring’s cardiovascular structure and function.

Objective
To investigate the association of maternal glycemia during pregnancy with cardiovascular risk markers in their children in GUSTO, a Singaporean birth cohort study.

Methods
Around 26 weeks’ gestation, a 75 g oral glucose tolerance test was performed and fasting plasma glucose (FPG) and 2-hour postprandial plasma glucose (PPPG) concentrations were measured. Gestational diabetes mellitus (GDM) was defined using WHO 1999 diagnostic criteria. At 6 years of age, we measured the child’s carotid intima-media thickness (cIMT), carotid-femoral pulse wave velocity (cfPWV), aortic augmentation index (AIx), and blood pressure (BP). Association of maternal glycemia during pregnancy with cardiovascular risk markers in their children were analyzed using multiple linear and logistic regressions.

Results
Analysis were performed on 479 mother–child dyads. Higher maternal FPG was associated with higher cIMT and, in males, with a higher cfPWV in the offspring (adjusted β [CI 95%], cIMT: 0.08 per 10mm increase [0.02; 0.15], cfPWV: 0.36 m/s [0.01; 0.70]). Higher 2-hour PPPG was associated with higher cfPWV and AIx. Gestational diabetes mellitus was associated with higher AIx. No association was found between maternal glycemia and their offspring blood pressure.

Conclusions
among mothers without pre-existing diabetes, higher glycemia during pregnancy was associated with mild structural and functional vascular changes in their children at 6 years of age across a continuum. These results support the necessity to monitor maternal glycemia during pregnancy even in the absence of pre-existing diabetes or diagnosed GDM.

Text
Cimt_PWV_cardiometabolic_JCEM_080420_without_edits - Accepted Manuscript
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More information

Accepted/In Press date: 16 April 2020
e-pub ahead of print date: 21 April 2020
Published date: July 2020
Keywords: AIx, PWV, cIMT, children, maternal glycemia, pregnancy

Identifiers

Local EPrints ID: 440978
URI: http://eprints.soton.ac.uk/id/eprint/440978
ISSN: 0021-972X
PURE UUID: a3142405-6f1f-47a0-8cda-00c0ac144aaa
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 26 May 2020 16:32
Last modified: 04 Aug 2022 04:03

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Contributors

Author: Wen Lun Yuan
Author: J. Lin
Author: Michael S. Kramer
Author: Keith Godfrey ORCID iD
Author: Peter D. Gluckman
Author: Yap-Seng Chong
Author: Lynette P. Shek
Author: Kok Hian Tan
Author: Shiao-Yng Chan
Author: Johan G. Eriksson
Author: Fabian Yap
Author: Yung Seng Lee
Author: Jonathan T.L. Choo
Author: L.H. Ling

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