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The Prospective studies of Atherosclerosis (Proof-ATHERO) consortium: Design and rationale

The Prospective studies of Atherosclerosis (Proof-ATHERO) consortium: Design and rationale
The Prospective studies of Atherosclerosis (Proof-ATHERO) consortium: Design and rationale
Atherosclerosis – the pathophysiological mechanism shared by most cardiovascular diseases – can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, ­ankle-brachial index, pulse wave velocity, and coronary ­artery calcium. The Prospective Studies of Atherosclerosis ­(Proof-ATHERO) consortium (https://clinicalepi.i-med.ac.at/research/proof-athero/) collates de-identified individual-participant data of studies with information on atherosclerosis measures, risk factors for cardiovascular disease, and incidence of cardiovascular diseases. It currently comprises 74 studies that involve 106,846 participants from 25 countries and over 40 cities. In summary, 21 studies recruited participants from the general population (n = 67,784), 16 from high-risk populations (n = 22,677), and 37 as part of clinical trials (n = 16,385). Baseline years of contributing studies range from April 1980 to July 2014; the latest follow-up was until June 2019. Mean age at baseline was 59 years (standard deviation: 10) and 50% were female. Over a total of 830,619 person-years of follow-up, 17,270 incident cardiovascular events (including coronary heart disease and stroke) and 13,270 deaths were recorded, corresponding to cumulative incidences of 2.1% and 1.6% per annum, respectively. The consortium is coordinated by the Clinical Epidemiology Team at the Medical University of Innsbruck, Austria. Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHERO central database. Statistical analyses are being conducted according to pre-defined analysis plans and use established methods for individual-participant data meta-analysis. Capitalising on its large sample size, the multi-institutional collaborative Proof-ATHERO consortium aims to better characterise, understand, and predict the development of atherosclerosis and its clinical consequences.
Atherosclerosis, Cardiovascular disease, Consortium, Individual-participant data, Prospective studies, Repeat measurements
0304-324X
447-459
Tschiderer, Lena
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Seekircher, Lisa
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Klingenschmid, Gerhard
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Izzo, Raffaele
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Baldassarre, Damiano
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Iglseder, Bernhard
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Calabresi, Laura
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Liu, Jing
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Price, Jackie F.
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Bae, Jang-Ho
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Brouwers, Frank P.
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de Groot, Eric
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Schmidt, Caroline
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Bergström, Göran
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Aşçi, Gülay
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Gresele, Paolo
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Okazaki, Shuhei
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Kapellas, Kostas
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Landecho, Manuel F.
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Sattar, Naveed
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Agewall, Stefan
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Zou, Zhi-Yong
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Byrne, Christopher
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Nanayakkara, Prabath W. B.
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Papagianni, Aikaterini
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Witham, Miles D.
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Bernal, Enrique
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Ekart, Robert
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van Agtmael, Michiel A.
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Neves, Mario F.
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Sato, Eiichi
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Ezhov, Marat
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Walters, Matthew
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Olsen, Michael H.
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Stolić, Radojica
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Zozulińska-Ziółkiewicz, Dorota A.
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et al.
Tschiderer, Lena
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Seekircher, Lisa
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Klingenschmid, Gerhard
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Izzo, Raffaele
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Baldassarre, Damiano
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Iglseder, Bernhard
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Calabresi, Laura
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Liu, Jing
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Price, Jackie F.
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Bae, Jang-Ho
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Brouwers, Frank P.
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de Groot, Eric
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Schmidt, Caroline
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Bergström, Göran
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Aşçi, Gülay
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Gresele, Paolo
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Okazaki, Shuhei
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Kapellas, Kostas
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Landecho, Manuel F.
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Sattar, Naveed
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Agewall, Stefan
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Zou, Zhi-Yong
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Byrne, Christopher
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Nanayakkara, Prabath W. B.
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Papagianni, Aikaterini
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Witham, Miles D.
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Bernal, Enrique
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Ekart, Robert
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van Agtmael, Michiel A.
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Neves, Mario F.
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Sato, Eiichi
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Ezhov, Marat
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Walters, Matthew
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Olsen, Michael H.
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Stolić, Radojica
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Zozulińska-Ziółkiewicz, Dorota A.
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Tschiderer, Lena, Seekircher, Lisa and Klingenschmid, Gerhard , et al. (2020) The Prospective studies of Atherosclerosis (Proof-ATHERO) consortium: Design and rationale. Gerontology, 66 (5), 447-459. (doi:10.1159/000508498).

Record type: Article

Abstract

Atherosclerosis – the pathophysiological mechanism shared by most cardiovascular diseases – can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, ­ankle-brachial index, pulse wave velocity, and coronary ­artery calcium. The Prospective Studies of Atherosclerosis ­(Proof-ATHERO) consortium (https://clinicalepi.i-med.ac.at/research/proof-athero/) collates de-identified individual-participant data of studies with information on atherosclerosis measures, risk factors for cardiovascular disease, and incidence of cardiovascular diseases. It currently comprises 74 studies that involve 106,846 participants from 25 countries and over 40 cities. In summary, 21 studies recruited participants from the general population (n = 67,784), 16 from high-risk populations (n = 22,677), and 37 as part of clinical trials (n = 16,385). Baseline years of contributing studies range from April 1980 to July 2014; the latest follow-up was until June 2019. Mean age at baseline was 59 years (standard deviation: 10) and 50% were female. Over a total of 830,619 person-years of follow-up, 17,270 incident cardiovascular events (including coronary heart disease and stroke) and 13,270 deaths were recorded, corresponding to cumulative incidences of 2.1% and 1.6% per annum, respectively. The consortium is coordinated by the Clinical Epidemiology Team at the Medical University of Innsbruck, Austria. Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHERO central database. Statistical analyses are being conducted according to pre-defined analysis plans and use established methods for individual-participant data meta-analysis. Capitalising on its large sample size, the multi-institutional collaborative Proof-ATHERO consortium aims to better characterise, understand, and predict the development of atherosclerosis and its clinical consequences.

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Accepted/In Press date: 7 May 2020
e-pub ahead of print date: 1 July 2020
Published date: 1 September 2020
Additional Information: Funding Information: L. Tschiderer reports grants from the Dr.-Johannes-and-Hertha-Tuba Foundation during the conduct of the study and nonfinancial support from Sanofi outside the submitted work. L. Seekircher reports non-financial support from Sanofi outside the submitted work. G. Klingenschmid reports non-financial support from Sanofi and Pfizer outside the submitted work. N. Sattar reports personal fees from Amgen, AstraZeneca, Boehringer Ingel-heim, Eli-Lilly, Novo Nordisk, Sanofi, and Pfizer and grants from Boehringer Ingelheim outside the submitted work. S.E. Kjeldsen reports personal fees from Merck Darmstadt, MSD Whitehouse Station, Sanofi Paris, and Takeda Chicago outside the submitted work. S. Kiechl reports grants from Austrian Promotion Agency FFG outside the submitted work. G.D. Norata reports grants from Pfizer and Amgen and personal fees from Sanofi, Amgen, Alnyl-am, and Novartis outside the submitted work. P. Willeit reports grants from the Dr.-Johannes-and-Hertha-Tuba Foundation and the Austrian Science Fund FWF during the conduct of the study. Other authors have no conflicts of interest. Funding Information: This work was funded by the Austrian Science Fund (FWF) (P 32488) and the Dr.-Johannes-and-Hertha-Tuba Foundation. Funders of individual studies contributing to the present analysis arelistedon the Proof-ATHERO webpage(https://clinicalepi.i-med. ac.at/research/proof-athero/studies/). Publisher Copyright: © 2020 The Author(s) Published by S. Karger AG, Basel.
Keywords: Atherosclerosis, Cardiovascular disease, Consortium, Individual-participant data, Prospective studies, Repeat measurements

Identifiers

Local EPrints ID: 441280
URI: http://eprints.soton.ac.uk/id/eprint/441280
DOI: doi:10.1159/000508498
ISSN: 0304-324X
PURE UUID: 7784c909-1e79-47d4-8d4f-b0c54bca1e87
ORCID for Christopher Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 08 Jun 2020 16:32
Last modified: 17 Mar 2024 05:37

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Contributors

Author: Lena Tschiderer
Author: Lisa Seekircher
Author: Gerhard Klingenschmid
Author: Raffaele Izzo
Author: Damiano Baldassarre
Author: Bernhard Iglseder
Author: Laura Calabresi
Author: Jing Liu
Author: Jackie F. Price
Author: Jang-Ho Bae
Author: Frank P. Brouwers
Author: Eric de Groot
Author: Caroline Schmidt
Author: Göran Bergström
Author: Gülay Aşçi
Author: Paolo Gresele
Author: Shuhei Okazaki
Author: Kostas Kapellas
Author: Manuel F. Landecho
Author: Naveed Sattar
Author: Stefan Agewall
Author: Zhi-Yong Zou
Author: Christopher Byrne ORCID iD
Author: Prabath W. B. Nanayakkara
Author: Aikaterini Papagianni
Author: Miles D. Witham
Author: Enrique Bernal
Author: Robert Ekart
Author: Michiel A. van Agtmael
Author: Mario F. Neves
Author: Eiichi Sato
Author: Marat Ezhov
Author: Matthew Walters
Author: Michael H. Olsen
Author: Radojica Stolić
Author: Dorota A. Zozulińska-Ziółkiewicz
Corporate Author: et al.

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