The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

Accepted/In Press date: 3 April 2020

Published date: 26 May 2020

Additional Information: Funding Information: We would first like to acknowledge all UK Biobank participants for not only generously dedicating their free time to participate, but for also maintaining contact over many years that has made an imaging study of this scale possible. L.M.G. was funded by a Wellcome Trust Clinical Research Training Fellowship (107190/Z/15/Z). A.F.F. acknowledges past and ongoing contributions of Le Zhang, Rahman Attar, Dr Marco Pereañez, Mohsen Farzi, Dr Jose Maria Pozo, Milton Hoz and Prof. J Mark Wilkinson on setting up the CMR and DXA quality assessment and quantitative analysis pipelines within the UKB. He also acknowledges partial support from EPSRC (EP/N026993/1), the Royal Academy of Engineering Chair in Emerging Technology (CiET1819/19) and the European Commission (FP7-ICT-2011-9-601055,H2020-SC1-PM-16-2017-777119, H2020-SC1-PM-17-2017-777090). P.L. acknowledges support from the NIHR Oxford Biomedical Research Centre, Oxford BHF Centre for Research Excellence and EPSRC. P.M.M. acknowledges generous personal and research support from the Edmond J Safra Foundation and Lily Safra, an NIHR Senior Investigator Award, the UK Dementia Research Institute and the NIHR Biomedical Research Centre at Imperial College London”. S.E.P. acknowledges support from the National Institute for Health Research Barts Biomedical Research Centre. S.M.S. and K.L.M. are supported by Wellcome Trust. The brain image processing is carried out on compute clusters at the Oxford Biomedical Research Computing (BMRC) facility and FMRIB (part of the Wellcome Centre for Integrative Neuroimaging). BMRC is a joint development between the Wellcome Centre for Human Genetics and the Big Data Institute, supported by Health Data Research UK and the NIHR Oxford Biomedical Research Centre. We are grateful to Dr Eleni Kariki and the late Professor Judith Adams for their adjudication of DXA-related incidental findings, to Dr Neil Rane and formerly Dr Alan Jackson for adjudication of brain-related incidental findings, Dr Stephen Lee for adjudication of body-related incidental findings, and Dr Francesca Pugliese and formerly Dr Alexia Rossi and Dr Ermanno Capuano for adjudication of cardiac-related incidental findings. Christie’s Medical Physics provide MR safety support/advice as well as radiation protection advice. We would like to thank Mr Jonathan Price for his helpful comments on the custom-built PACS and Dr Mihir Sanghvi for his contributions to the cardiac MRI section. The following are current members of the UK Biobank Imaging Working Group; Paul Matthews, Tony Goldstone, Andrew Blamire, Steffen Petersen, Cathie Sudlow, Lorna Gibson, Alan Jackson, Naomi Allen, Rory Collins, Paul Leeson, Karla Miller, Stefan Neubauer, Stephen Smith, Nicholas Harvey, Jimmy Bell and E. Louise Thomas. The UK Biobank imaging project is funded by the Medical Research Council and the Wellcome Trust. The repeat imaging of 10,000 participants is funded by Dementias Platform UK. Funding Information: Nicholas C. Harvey acknowledges consultancy/grant support/honoraria from Alliance for Better Bone Health, AMGEN, UCB, Radius Health, MSD, Eli Lilly, Servier, Shire, Consilient Healthcare and Internis Pharma, outside the submitted work. Paul Leeson acknowledges grant support from Lantheus Medical Imaging and Fukuda, consultancy fees from Intelligent Ultrasound and is a non-executive director of Ultromics. Steffen E. Publisher Copyright: © 2020, The Author(s).

Local EPrints ID: 441561

URI: http://eprints.soton.ac.uk/id/eprint/441561

DOI: doi:10.1038/s41467-020-15948-9

ISSN: 2041-1723

PURE UUID: f5cd9e05-9cfc-4e77-9f60-eeb3040a2150

ORCID for Nicholas Harvey: orcid.org/0000-0002-8194-2512

Date deposited: 18 Jun 2020 16:30

Last modified: 06 Jun 2024 01:42