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The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions
The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions
UK Biobank is a population-based cohort of half a million participants aged 40–69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world’s largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.
2041-1723
Littlejohns, Thomas J.
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Holliday, Jo
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Gibson, Lorna M.
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Garratt, Steve
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Oesingmann, Niels
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Alfaro-Almagro, Fidel
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Bell, Jimmy D.
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Boultwood, Chris
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Collins, Rory
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Conroy, Megan C
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Crabtree, Nicola
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Doherty, Nicola
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Frangi, Alejandro
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Harvey, Nicholas
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Leeson, Paul
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Miller, Karla L.
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Neubauer, Stefan
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Petersen, Steffen E.
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Sellors, Jonathan
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Sheard, Simon
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Smith, Stephen M.
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Sudlow, Cathie LM
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Matthews, Paul M.
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Allen, Naomi E.
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Littlejohns, Thomas J.
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Holliday, Jo
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Gibson, Lorna M.
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Garratt, Steve
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Oesingmann, Niels
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Alfaro-Almagro, Fidel
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Bell, Jimmy D.
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Boultwood, Chris
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Collins, Rory
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Conroy, Megan C
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Crabtree, Nicola
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Doherty, Nicola
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Frangi, Alejandro
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Harvey, Nicholas
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Leeson, Paul
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Miller, Karla L.
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Neubauer, Stefan
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Petersen, Steffen E.
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Sellors, Jonathan
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Sheard, Simon
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Smith, Stephen M.
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Sudlow, Cathie LM
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Matthews, Paul M.
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Allen, Naomi E.
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Littlejohns, Thomas J., Holliday, Jo, Gibson, Lorna M., Garratt, Steve, Oesingmann, Niels, Alfaro-Almagro, Fidel, Bell, Jimmy D., Boultwood, Chris, Collins, Rory, Conroy, Megan C, Crabtree, Nicola, Doherty, Nicola, Frangi, Alejandro, Harvey, Nicholas, Leeson, Paul, Miller, Karla L., Neubauer, Stefan, Petersen, Steffen E., Sellors, Jonathan, Sheard, Simon, Smith, Stephen M., Sudlow, Cathie LM, Matthews, Paul M. and Allen, Naomi E. (2020) The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions. Nature Communications, 11 (1), [2624]. (doi:10.1038/s41467-020-15948-9).

Record type: Article

Abstract

UK Biobank is a population-based cohort of half a million participants aged 40–69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world’s largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.

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More information

Accepted/In Press date: 3 April 2020
Published date: 26 May 2020

Identifiers

Local EPrints ID: 441561
URI: http://eprints.soton.ac.uk/id/eprint/441561
ISSN: 2041-1723
PURE UUID: f5cd9e05-9cfc-4e77-9f60-eeb3040a2150
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 18 Jun 2020 16:30
Last modified: 26 Nov 2021 02:48

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Contributors

Author: Thomas J. Littlejohns
Author: Jo Holliday
Author: Lorna M. Gibson
Author: Steve Garratt
Author: Niels Oesingmann
Author: Fidel Alfaro-Almagro
Author: Jimmy D. Bell
Author: Chris Boultwood
Author: Rory Collins
Author: Megan C Conroy
Author: Nicola Crabtree
Author: Nicola Doherty
Author: Alejandro Frangi
Author: Nicholas Harvey ORCID iD
Author: Paul Leeson
Author: Karla L. Miller
Author: Stefan Neubauer
Author: Steffen E. Petersen
Author: Jonathan Sellors
Author: Simon Sheard
Author: Stephen M. Smith
Author: Cathie LM Sudlow
Author: Paul M. Matthews
Author: Naomi E. Allen

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