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Microglia in Motor Neuron Disease

Microglia in Motor Neuron Disease
Microglia in Motor Neuron Disease
Motor Neuron Disease (MND) is a fatal neurodegenerative condition, which is characterised by the selective loss of the upper and lower motor neurons. At the sites of motor neuron injury, accumulations of activated microglia, the primary immune cells of the central nervous system, are commonly observed in both human post-mortem studies and animal models of MND. Microglial activation has been found to correlate with many clinical features and importantly, the speed of disease progression in humans. Both anti-inflammatory and pro-inflammatory microglial responses have been shown to influence disease progression in humans and models of MND. As such, microglia could both contribute to and protect against inflammatory mechanisms of pathogenesis in MND. While murine models have characterised the microglial response to MND, these studies have painted a complex and often -contradictory picture, indicating a need for further characterisation in humans. This review examines the potential role microglia play in MND, in human and animal studies. Both the pro-inflammatory and anti-inflammatory responses will be addressed, throughout the course of disease, followed by the potential of microglia as a target in the development of disease modifying treatments for MND.
Motor Neuron Disease, microglia, inflammation, humans
0305-1846
Ashford, Bridget A.
46c8eb16-49ba-4cb0-83bb-405bc9888408
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Cooper-Knock, Johnathan
d8fe0d9d-cd2c-44b6-9bf5-020640eaae35
Heath, Paul R.
c7ba37cc-e6f5-4c6a-81c7-6d1bf3146ec9
Simpson, Julie E.
4f5435d8-fc27-40f2-be80-2bf40569cd7d
Highley, J. Robin
bfe52e8e-69c0-4b17-9b1c-a40cc3ebd712
Ashford, Bridget A.
46c8eb16-49ba-4cb0-83bb-405bc9888408
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Cooper-Knock, Johnathan
d8fe0d9d-cd2c-44b6-9bf5-020640eaae35
Heath, Paul R.
c7ba37cc-e6f5-4c6a-81c7-6d1bf3146ec9
Simpson, Julie E.
4f5435d8-fc27-40f2-be80-2bf40569cd7d
Highley, J. Robin
bfe52e8e-69c0-4b17-9b1c-a40cc3ebd712

Ashford, Bridget A., Boche, Delphine, Cooper-Knock, Johnathan, Heath, Paul R., Simpson, Julie E. and Highley, J. Robin (2020) Microglia in Motor Neuron Disease. Neuropathology and Applied Neurobiology, [NAN-2020-0025.R2]. (In Press)

Record type: Review

Abstract

Motor Neuron Disease (MND) is a fatal neurodegenerative condition, which is characterised by the selective loss of the upper and lower motor neurons. At the sites of motor neuron injury, accumulations of activated microglia, the primary immune cells of the central nervous system, are commonly observed in both human post-mortem studies and animal models of MND. Microglial activation has been found to correlate with many clinical features and importantly, the speed of disease progression in humans. Both anti-inflammatory and pro-inflammatory microglial responses have been shown to influence disease progression in humans and models of MND. As such, microglia could both contribute to and protect against inflammatory mechanisms of pathogenesis in MND. While murine models have characterised the microglial response to MND, these studies have painted a complex and often -contradictory picture, indicating a need for further characterisation in humans. This review examines the potential role microglia play in MND, in human and animal studies. Both the pro-inflammatory and anti-inflammatory responses will be addressed, throughout the course of disease, followed by the potential of microglia as a target in the development of disease modifying treatments for MND.

Text
Ashford-et-al.-2020-Final-text-only-version-for-resubmission-edited - Accepted Manuscript
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More information

Accepted/In Press date: 14 June 2020
Keywords: Motor Neuron Disease, microglia, inflammation, humans

Identifiers

Local EPrints ID: 441694
URI: http://eprints.soton.ac.uk/id/eprint/441694
ISSN: 0305-1846
PURE UUID: 33a69ae0-5cba-4132-af82-d0b92f5c6a23
ORCID for Delphine Boche: ORCID iD orcid.org/0000-0002-5884-130X

Catalogue record

Date deposited: 24 Jun 2020 16:30
Last modified: 14 Jun 2021 04:01

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Contributors

Author: Bridget A. Ashford
Author: Delphine Boche ORCID iD
Author: Johnathan Cooper-Knock
Author: Paul R. Heath
Author: Julie E. Simpson
Author: J. Robin Highley

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