The University of Southampton
University of Southampton Institutional Repository

Impact of COVID-19 on pediatric asthma: practice adjustments and disease burden

Impact of COVID-19 on pediatric asthma: practice adjustments and disease burden
Impact of COVID-19 on pediatric asthma: practice adjustments and disease burden

Background: It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic. Objective: To describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease burden in their patients. Methods: An online survey was sent to members of the Pediatric Asthma in Real Life think tank and the World Allergy Organization Pediatric Asthma Committee. It included questions on service provision, disease burden, and the clinical course of confirmed cases of COVID-19 infection among children with asthma. Results: Ninety-one respondents, caring for an estimated population of more than 133,000 children with asthma, completed the survey. COVID-19 significantly impacted pediatric asthma services: 39% ceased physical appointments, 47% stopped accepting new patients, and 75% limited patients' visits. Consultations were almost halved to a median of 20 (interquartile range, 10-25) patients per week. Virtual clinics and helplines were launched in most centers. Better than expected disease control was reported in 20% (10%-40%) of patients, whereas control was negatively affected in only 10% (7.5%-12.5%). Adherence also appeared to increase. Only 15 confirmed cases of COVID-19 were reported among the population; the estimated incidence is not apparently different from the reports of general pediatric cohorts. Conclusions: Children with asthma do not appear to be disproportionately affected by COVID-19. Outcomes may even have improved, possibly through increased adherence and/or reduced exposures. Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters.

Adherence, Asthma, COVID-19, Children, Control, SARS-CoV2, Virus
2213-2198
2592-2599.e3
Papadopoulos, Nikolaos G.
acf133b9-9a22-4637-a7f3-d67f509d9353
Custovic, Adnan
17d8d092-73b8-44fb-bf48-5cea7b29e3fc
Deschildre, Antoine
0b3562a0-65e1-4e75-aba4-469371cd2c93
Mathioudakis, Alexander G.
ffbdd50a-79dc-439a-8c88-f25b4a004d45
Phipatanakul, Wanda
f89a39f9-77b7-4ceb-8bc1-57d9eea2886b
Wong, Gary
76551efa-3264-4f85-a436-5107e0b2432f
Xepapadaki, Paraskevi
85e1d823-e524-4983-9b2c-4bbc194fd1d8
Agache, Ioana
5a821a60-9456-48af-914b-476caa540f8f
Bacharier, Leonard
883ffe42-357c-417c-b2ee-9003e8b25a65
Bonini, Matteo
9d1c57e7-dc83-4eb2-9e1c-5cadd0c7fbf5
Castro-Rodriguez, Jose A.
b4b17a58-d7ad-4cfd-afbb-7edc0e3cbbb7
Chen, Zhimin
72e7edd6-4122-440d-9ca2-b85ba95f7a3a
Craig, Timothy
6297a26a-08f5-4d41-9872-e5f56d13aa40
Ducharme, Francine M.
8b2778d1-39d5-4fb7-9dcf-04268e2fed99
El-Sayed, Zeinab Awad
7adbec5d-283e-4451-b54f-0b3c17b30a3f
Feleszko, Wojciech
c1b0735c-bedf-4bf8-b319-1c7a920108a8
Fiocci, Alessandro
55b2c5b5-e4d2-4fa7-8f93-b1420d1853d2
Garcia-Marcos, Luis
8d686dff-f4ad-4c9e-b94f-33a1d7e17385
Gern, James E.
b6cdff51-578a-4098-8c0f-ff88d919283e
Goh, Anne
2118dde3-1148-43e6-adc1-3d43c7d468fc
Gómez, René Maximiliano
99f2c587-6ee7-44d3-8fea-0d11fa24639e
Hamelmann, Eckard H.
e4bc1e13-f76e-4b28-a11d-f7ac54d82d40
Hedlin, Gunilla
09e3d406-6441-47ec-b4fa-860e6de096fb
Hossny, Elham M.
4c0dd72f-34ef-418b-9a13-33cc5f0424bc
Jartti, Tuomas
eb9461e3-fb04-4ce4-a3a1-2af83a9b39f3
Kalayci, Omer
0cbe2091-7ce9-4df4-bcc0-20a53f5e5849
Kaplan, Alan
5a6fefa8-f438-4519-8605-6ddb7c28647c
Konrandsen, Jon
faea29b2-577e-46ca-afba-1c715f89b0fb
Kuna, Piotr
0982046a-9893-4920-842d-49f032302edc
Lau, Susanne
66bbde71-a61f-42fa-8ddb-8a94edcb1017
Le Souef, Peter
12bcd14b-a16c-4e56-b1c2-ef13729b9e30
Lemanske, Robert F.
af9c0822-7381-4a32-ba76-d0cf3aa6a7e0
Makela, Mika J.
ba3eb3f6-69c2-41cf-9a47-5abf120e8c7d
Morais-Almeida, Mário
53900a13-e2de-41c0-bf70-8a92acb3a273
Murray, Clare
afa681f7-2a47-417e-b379-02cdf695e3ae
Nagaraju, Karthik
12cf5007-3d86-4832-a34a-4f8e2acd2be7
Namazova-Baranova, Leyla
f7dcff77-9668-43dd-8193-16ebca7e291b
Garcia, Antonio Nieto
6df506a2-2fc8-4565-9eff-470daedf4514
Osman, Yusuf
9f8341f7-43cf-4c75-b132-5e6c4086bdf4
Pitrez, Paulo M.C.
834b7769-65ff-406e-b0bd-bf4c80faa401
Pohunek, Petr
9f8887dc-b4e7-4a1b-a1e8-4ca373fd30d0
Pozo Beltrán, Cesar Fireth
4358c9f1-0565-4c66-9a02-ec591276c6b1
Roberts, Graham C.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Valiulis, Arunas
aa786492-5fcf-42eb-bb12-6e21aa83d540
Zar, Heather J.
a00ab263-ace5-4d01-8ec6-23f5b8f09f8d
PeARL collaborators
Papadopoulos, Nikolaos G.
acf133b9-9a22-4637-a7f3-d67f509d9353
Custovic, Adnan
17d8d092-73b8-44fb-bf48-5cea7b29e3fc
Deschildre, Antoine
0b3562a0-65e1-4e75-aba4-469371cd2c93
Mathioudakis, Alexander G.
ffbdd50a-79dc-439a-8c88-f25b4a004d45
Phipatanakul, Wanda
f89a39f9-77b7-4ceb-8bc1-57d9eea2886b
Wong, Gary
76551efa-3264-4f85-a436-5107e0b2432f
Xepapadaki, Paraskevi
85e1d823-e524-4983-9b2c-4bbc194fd1d8
Agache, Ioana
5a821a60-9456-48af-914b-476caa540f8f
Bacharier, Leonard
883ffe42-357c-417c-b2ee-9003e8b25a65
Bonini, Matteo
9d1c57e7-dc83-4eb2-9e1c-5cadd0c7fbf5
Castro-Rodriguez, Jose A.
b4b17a58-d7ad-4cfd-afbb-7edc0e3cbbb7
Chen, Zhimin
72e7edd6-4122-440d-9ca2-b85ba95f7a3a
Craig, Timothy
6297a26a-08f5-4d41-9872-e5f56d13aa40
Ducharme, Francine M.
8b2778d1-39d5-4fb7-9dcf-04268e2fed99
El-Sayed, Zeinab Awad
7adbec5d-283e-4451-b54f-0b3c17b30a3f
Feleszko, Wojciech
c1b0735c-bedf-4bf8-b319-1c7a920108a8
Fiocci, Alessandro
55b2c5b5-e4d2-4fa7-8f93-b1420d1853d2
Garcia-Marcos, Luis
8d686dff-f4ad-4c9e-b94f-33a1d7e17385
Gern, James E.
b6cdff51-578a-4098-8c0f-ff88d919283e
Goh, Anne
2118dde3-1148-43e6-adc1-3d43c7d468fc
Gómez, René Maximiliano
99f2c587-6ee7-44d3-8fea-0d11fa24639e
Hamelmann, Eckard H.
e4bc1e13-f76e-4b28-a11d-f7ac54d82d40
Hedlin, Gunilla
09e3d406-6441-47ec-b4fa-860e6de096fb
Hossny, Elham M.
4c0dd72f-34ef-418b-9a13-33cc5f0424bc
Jartti, Tuomas
eb9461e3-fb04-4ce4-a3a1-2af83a9b39f3
Kalayci, Omer
0cbe2091-7ce9-4df4-bcc0-20a53f5e5849
Kaplan, Alan
5a6fefa8-f438-4519-8605-6ddb7c28647c
Konrandsen, Jon
faea29b2-577e-46ca-afba-1c715f89b0fb
Kuna, Piotr
0982046a-9893-4920-842d-49f032302edc
Lau, Susanne
66bbde71-a61f-42fa-8ddb-8a94edcb1017
Le Souef, Peter
12bcd14b-a16c-4e56-b1c2-ef13729b9e30
Lemanske, Robert F.
af9c0822-7381-4a32-ba76-d0cf3aa6a7e0
Makela, Mika J.
ba3eb3f6-69c2-41cf-9a47-5abf120e8c7d
Morais-Almeida, Mário
53900a13-e2de-41c0-bf70-8a92acb3a273
Murray, Clare
afa681f7-2a47-417e-b379-02cdf695e3ae
Nagaraju, Karthik
12cf5007-3d86-4832-a34a-4f8e2acd2be7
Namazova-Baranova, Leyla
f7dcff77-9668-43dd-8193-16ebca7e291b
Garcia, Antonio Nieto
6df506a2-2fc8-4565-9eff-470daedf4514
Osman, Yusuf
9f8341f7-43cf-4c75-b132-5e6c4086bdf4
Pitrez, Paulo M.C.
834b7769-65ff-406e-b0bd-bf4c80faa401
Pohunek, Petr
9f8887dc-b4e7-4a1b-a1e8-4ca373fd30d0
Pozo Beltrán, Cesar Fireth
4358c9f1-0565-4c66-9a02-ec591276c6b1
Roberts, Graham C.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Valiulis, Arunas
aa786492-5fcf-42eb-bb12-6e21aa83d540
Zar, Heather J.
a00ab263-ace5-4d01-8ec6-23f5b8f09f8d

Papadopoulos, Nikolaos G., Custovic, Adnan, Deschildre, Antoine, Mathioudakis, Alexander G., Phipatanakul, Wanda, Wong, Gary, Xepapadaki, Paraskevi, Agache, Ioana, Bacharier, Leonard, Bonini, Matteo, Castro-Rodriguez, Jose A., Chen, Zhimin, Craig, Timothy, Ducharme, Francine M., El-Sayed, Zeinab Awad, Feleszko, Wojciech, Fiocci, Alessandro, Garcia-Marcos, Luis, Gern, James E., Goh, Anne, Gómez, René Maximiliano, Hamelmann, Eckard H., Hedlin, Gunilla, Hossny, Elham M., Jartti, Tuomas, Kalayci, Omer, Kaplan, Alan, Konrandsen, Jon, Kuna, Piotr, Lau, Susanne, Le Souef, Peter, Lemanske, Robert F., Makela, Mika J., Morais-Almeida, Mário, Murray, Clare, Nagaraju, Karthik, Namazova-Baranova, Leyla, Garcia, Antonio Nieto, Osman, Yusuf, Pitrez, Paulo M.C., Pohunek, Petr, Pozo Beltrán, Cesar Fireth, Roberts, Graham C., Valiulis, Arunas and Zar, Heather J. , PeARL collaborators (2020) Impact of COVID-19 on pediatric asthma: practice adjustments and disease burden. The Journal of Allergy and Clinical immunology: In Practice, 8 (8), 2592-2599.e3. (doi:10.1016/j.jaip.2020.06.001).

Record type: Article

Abstract

Background: It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic. Objective: To describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease burden in their patients. Methods: An online survey was sent to members of the Pediatric Asthma in Real Life think tank and the World Allergy Organization Pediatric Asthma Committee. It included questions on service provision, disease burden, and the clinical course of confirmed cases of COVID-19 infection among children with asthma. Results: Ninety-one respondents, caring for an estimated population of more than 133,000 children with asthma, completed the survey. COVID-19 significantly impacted pediatric asthma services: 39% ceased physical appointments, 47% stopped accepting new patients, and 75% limited patients' visits. Consultations were almost halved to a median of 20 (interquartile range, 10-25) patients per week. Virtual clinics and helplines were launched in most centers. Better than expected disease control was reported in 20% (10%-40%) of patients, whereas control was negatively affected in only 10% (7.5%-12.5%). Adherence also appeared to increase. Only 15 confirmed cases of COVID-19 were reported among the population; the estimated incidence is not apparently different from the reports of general pediatric cohorts. Conclusions: Children with asthma do not appear to be disproportionately affected by COVID-19. Outcomes may even have improved, possibly through increased adherence and/or reduced exposures. Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters.

Text
COVID PeARL survey_accepted - Accepted Manuscript
Download (54kB)

More information

Accepted/In Press date: 1 June 2020
e-pub ahead of print date: 17 June 2020
Published date: September 2020
Additional Information: Funding Information: This study was supported by the Respiratory Effectiveness Group (REG). REG has received support from AstraZeneca, Novartis, and Sanofi for continued work on Pediatric Asthma in Real Life. A.G.M. was supported by the National Institute of Health Research Manchester Biomedical Research Centre (NIHR Manchester BRC).Conflicts of interests: J. Konradsen reports grants from Region Stockholm, during the conduct of the study. N. G. Papadopoulos reports personal fees from ALK, Novartis, Nutricia, HAL, Menarini/FAES Farma, Sanofi, Mylan/MEDA, Biomay, AstraZeneca, GlaxoSmithKline (GSK), MSD, ASIT BIOTECH, and Boehringer Ingelheim and grants from Gerolymatos International SA and Capricare, outside the submitted work. A. Custovic reports personal fees from Novartis, Regeneron/Sanofi, Thermo Fisher Scientific, Boehringer Ingelheim, and Philips, outside the submitted work. A. Deschildre reports grants and personal fees from Stallergenes Greer and personal fees from Novartis, ALK, Teva, GSK, MEDA-MYLAN, CHIESI, AImmune, DBV Technologies, and Astra Zeneca, outside the submitted work. A. G. Mathioudakis reports grants from Boehringer Ingelheim, outside the submitted work. W. Phipatanakul reports grants from the National Institutes of Health (NIH); grants and personal fees from Genentech/Novartis and Sanofi/Rgeneron; personal fees from GSK; and nonfinancial support from Thermo Fisher, Lincoln Diagnostics, Alk Abello, and Monaghen, outside the submitted work. P. Xepapadaki reports personal fees from Nutricia, Nestle, Friesland, Uriach, Novartis Pharma AG, and GSK, outside the submitted work. L. Bacharier reports personal fees from Aerocrine, GSK, Genentech/Novartis, Merck, DBV Technologies, Teva, Boehringer Ingelheim, AstraZeneca, WebMD/Medscape, Sanofi/Regeneron, Vectura, and Circassia, outside the submitted work. T. Craig reports grants and personal fees from CSL Behring, Dyax, Takeda, BioCryst, and Pharming; personal fees from Grifols; and grants and nonfinancial support from GSK, Regeneron, and Novartis/Genetech, outside the submitted work. F. M. Ducharme reports grants from Thorasys Inc; personal fees from Jean-Coutu Pharmaceuticals; and nonfinancial support from Novartis Canada, and Trudell Medical, outside the submitted work. J. E. Gern reports grants from NIH/National Institute of Allergy and Infectious Diseases; personal fees from Regeneron, Ena Theraputics, and MedImmune, outside the submitted work; and personal fees and stock options from Meissa Vaccines Inc, outside the submitted work. A. Kaplan reports personal fees from Astra Zeneca, Behring, Boehringer Ingelheim, Covis, GSK, NovoNordisk, Novartis, Griffols, Pfizer, Sanofi, Teva, and Trudel, outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, AstraZeneca, Berlin Chemie Menarini, Hal, Lekam, Mylan, Novartis, Polpharma, and Teva, outside the submitted work. R. F. Lemanske reports grants from the NIH, Clinical and Translational Science Award (NIH), Childhood Origins of ASThma, and AsthmaNet; nonfinancial support from GSK, Boehringer Ingelheim, Merck, Teva, and the American Academy of Allergy, Asthma & Immunology; and personal fees from LSU, Elsevier, UpToDate, the University of Kentucky, ThermoFischer, and Food Allergy Research and Education Network, outside the submitted work. C. Murray reports personal fees from Novartis, GSK, Astra Zeneca, Thermo Fisher, and Boehringer Ingelheim, outside the submitted work. P. M. C. Pitrez reports grants from AstraZeneca, Chiesi, and Teva and personal fees from Astra Zeneca, Teva, Novartis, Mundipharma, S&D Pharma, and GSK, outside the submitted work. G. C. Roberts reports personal fees from ALK, Allergen Therapeutics, Meda Plus, and Merck; and a patent for the use of sublingual immunotherapy to prevent the development of allergy in at-risk infants, outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest. Publisher Copyright: © 2020 American Academy of Allergy, Asthma & Immunology
Keywords: Adherence, Asthma, COVID-19, Children, Control, SARS-CoV2, Virus

Identifiers

Local EPrints ID: 441725
URI: http://eprints.soton.ac.uk/id/eprint/441725
ISSN: 2213-2198
PURE UUID: a81575a6-40f0-4178-941d-4919d8d29732
ORCID for Graham C. Roberts: ORCID iD orcid.org/0000-0003-2252-1248

Catalogue record

Date deposited: 24 Jun 2020 16:49
Last modified: 17 Mar 2024 05:41

Export record

Altmetrics

Contributors

Author: Nikolaos G. Papadopoulos
Author: Adnan Custovic
Author: Antoine Deschildre
Author: Alexander G. Mathioudakis
Author: Wanda Phipatanakul
Author: Gary Wong
Author: Paraskevi Xepapadaki
Author: Ioana Agache
Author: Leonard Bacharier
Author: Matteo Bonini
Author: Jose A. Castro-Rodriguez
Author: Zhimin Chen
Author: Timothy Craig
Author: Francine M. Ducharme
Author: Zeinab Awad El-Sayed
Author: Wojciech Feleszko
Author: Alessandro Fiocci
Author: Luis Garcia-Marcos
Author: James E. Gern
Author: Anne Goh
Author: René Maximiliano Gómez
Author: Eckard H. Hamelmann
Author: Gunilla Hedlin
Author: Elham M. Hossny
Author: Tuomas Jartti
Author: Omer Kalayci
Author: Alan Kaplan
Author: Jon Konrandsen
Author: Piotr Kuna
Author: Susanne Lau
Author: Peter Le Souef
Author: Robert F. Lemanske
Author: Mika J. Makela
Author: Mário Morais-Almeida
Author: Clare Murray
Author: Karthik Nagaraju
Author: Leyla Namazova-Baranova
Author: Antonio Nieto Garcia
Author: Yusuf Osman
Author: Paulo M.C. Pitrez
Author: Petr Pohunek
Author: Cesar Fireth Pozo Beltrán
Author: Arunas Valiulis
Author: Heather J. Zar
Corporate Author: PeARL collaborators

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×