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Placental volume at 11 weeks is associated with offspring bone mass at birth and in later childhood: Findings from the Southampton Women’s Survey

Placental volume at 11 weeks is associated with offspring bone mass at birth and in later childhood: Findings from the Southampton Women’s Survey
Placental volume at 11 weeks is associated with offspring bone mass at birth and in later childhood: Findings from the Southampton Women’s Survey
Objectives
To investigate associations between placental volume (PV) at 11 weeks' gestation and offspring bone outcomes at birth, 6 years and 8 years.

Methods
3D ultrasound scanning was used to assess 11 week PV in a subset (n = 236) of the Southampton Women's Survey (a prospective mother-offspring cohort). Maternal anthropometric measures and lifestyle information were obtained pre-pregnancy and at 11 weeks' gestation. Offspring dual-energy x-ray absorptiometry scanning was performed within 2 weeks postnatally and at 6 and 8 years. Linear regression was used to assess associations between PV and bone outcomes, adjusting for offspring age at DXA and sex, and maternal age, height, smoking status, walking speed and triceps skinfold thickness. β are SD change in bone outcome per SD change in PV.

Results
In adjusted models, 11 week PV was positively associated with bone area (BA) at all time points, with evidence of persisting associations with increasing childhood age (birth: n = 80, β = 0.23 [95%CI = 0.03, 0.42], 6 years: n = 110, β = 0.17 [-0.01, 0.36], 8 years: n = 85, β = 0.13 [-0.09, 0.36]). Similar associations between 11 week PV and bone mineral content (BMC) were observed. Associations with size-corrected bone mineral content were weaker at birth but strengthened in later childhood (birth: n = 78, β = 0.07 [-0.21, 0.35], 6 years: n = 107, β = 0.13 [-0.08, 0.34], 8 years: n = 71, β = 0.19 [-0.05, 0.43]).

Conclusions
11 week PV is associated with DXA bone measures at birth, with evidence of persisting associations into later childhood. Further work is required to elucidate the contributions of placental morphology and function to gestational influences on skeletal development.
0143-4004
101-107
Woolford, S.J.
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Curtis, Elizabeth
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D'angelo, Stefania
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Mahon, Pamela
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Cooke, L.
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Cleal, Jane
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Crozier, Sarah
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Godfrey, Keith
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Inskip, Hazel
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Cooper, Cyrus
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Harvey, Nicholas
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Woolford, S.J.
a123d451-d086-45c0-a961-8704f5e90c90
Curtis, Elizabeth
12aba0c3-1e9e-49ef-a7e9-3247e649cdd6
D'angelo, Stefania
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Mahon, Pamela
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Cooke, L.
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Cleal, Jane
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Crozier, Sarah
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Godfrey, Keith
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Inskip, Hazel
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Cooper, Cyrus
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Harvey, Nicholas
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Woolford, S.J., Curtis, Elizabeth, D'angelo, Stefania, Mahon, Pamela, Cooke, L., Cleal, Jane, Crozier, Sarah, Godfrey, Keith, Inskip, Hazel, Cooper, Cyrus and Harvey, Nicholas (2020) Placental volume at 11 weeks is associated with offspring bone mass at birth and in later childhood: Findings from the Southampton Women’s Survey. Placenta, 99, 101-107. (doi:10.1016/j.placenta.2020.07.017).

Record type: Article

Abstract

Objectives
To investigate associations between placental volume (PV) at 11 weeks' gestation and offspring bone outcomes at birth, 6 years and 8 years.

Methods
3D ultrasound scanning was used to assess 11 week PV in a subset (n = 236) of the Southampton Women's Survey (a prospective mother-offspring cohort). Maternal anthropometric measures and lifestyle information were obtained pre-pregnancy and at 11 weeks' gestation. Offspring dual-energy x-ray absorptiometry scanning was performed within 2 weeks postnatally and at 6 and 8 years. Linear regression was used to assess associations between PV and bone outcomes, adjusting for offspring age at DXA and sex, and maternal age, height, smoking status, walking speed and triceps skinfold thickness. β are SD change in bone outcome per SD change in PV.

Results
In adjusted models, 11 week PV was positively associated with bone area (BA) at all time points, with evidence of persisting associations with increasing childhood age (birth: n = 80, β = 0.23 [95%CI = 0.03, 0.42], 6 years: n = 110, β = 0.17 [-0.01, 0.36], 8 years: n = 85, β = 0.13 [-0.09, 0.36]). Similar associations between 11 week PV and bone mineral content (BMC) were observed. Associations with size-corrected bone mineral content were weaker at birth but strengthened in later childhood (birth: n = 78, β = 0.07 [-0.21, 0.35], 6 years: n = 107, β = 0.13 [-0.08, 0.34], 8 years: n = 71, β = 0.19 [-0.05, 0.43]).

Conclusions
11 week PV is associated with DXA bone measures at birth, with evidence of persisting associations into later childhood. Further work is required to elucidate the contributions of placental morphology and function to gestational influences on skeletal development.

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More information

Accepted/In Press date: 16 July 2020
e-pub ahead of print date: 22 July 2020
Published date: 15 September 2020

Identifiers

Local EPrints ID: 442533
URI: http://eprints.soton.ac.uk/id/eprint/442533
ISSN: 0143-4004
PURE UUID: 444044fb-fafe-478a-bea1-899a851206f1
ORCID for Elizabeth Curtis: ORCID iD orcid.org/0000-0002-5147-0550
ORCID for Stefania D'angelo: ORCID iD orcid.org/0000-0002-7267-1837
ORCID for Jane Cleal: ORCID iD orcid.org/0000-0001-7978-4327
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 17 Jul 2020 16:31
Last modified: 22 Nov 2021 08:12

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Contributors

Author: S.J. Woolford
Author: Stefania D'angelo ORCID iD
Author: Pamela Mahon
Author: L. Cooke
Author: Jane Cleal ORCID iD
Author: Sarah Crozier ORCID iD
Author: Keith Godfrey ORCID iD
Author: Hazel Inskip ORCID iD
Author: Cyrus Cooper ORCID iD
Author: Nicholas Harvey ORCID iD

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