Perspective on thin film waveguides for on-chip mid-infrared spectroscopy of liquid biochemical analytes
Perspective on thin film waveguides for on-chip mid-infrared spectroscopy of liquid biochemical analytes
Miniaturized spectrometers offering low cost, low reagent consumption, high throughput, sensitivity and automation are the future of sensing and have significant applications in environmental monitoring and food safety, biotechnology, pharma-ceuticals and healthcare. Mid-infrared (MIR) spectroscopy employing complementary metal oxide semiconductor (CMOS) compatible thin film waveguides and microfluidics shows great promise towards highly integrated and robust detection tools and liquid handling. This perspective provides an overview of emergence of thin film optical waveguides used for evanes-cent field sensing of liquid chemical and biological samples for MIR absorption spectroscopy. The state of the art of new material and waveguide systems used for spectroscopic measurements in the MIR is presented. An outlook on the ad-vantages and future of waveguide-based MIR spectroscopy for application in clinical settings for point-of-care biochemical analysis is discussed.
10891-10901
Mittal, Vinita
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Mashanovich, Goran
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Wilkinson, James S.
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Mittal, Vinita
fd5ee9dd-7770-416f-8f47-50ca158b39b0
Mashanovich, Goran
c806e262-af80-4836-b96f-319425060051
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Mittal, Vinita, Mashanovich, Goran and Wilkinson, James S.
(2020)
Perspective on thin film waveguides for on-chip mid-infrared spectroscopy of liquid biochemical analytes.
Analytical Chemistry, 92 (16), .
(doi:10.1021/acs.analchem.0c01296).
Abstract
Miniaturized spectrometers offering low cost, low reagent consumption, high throughput, sensitivity and automation are the future of sensing and have significant applications in environmental monitoring and food safety, biotechnology, pharma-ceuticals and healthcare. Mid-infrared (MIR) spectroscopy employing complementary metal oxide semiconductor (CMOS) compatible thin film waveguides and microfluidics shows great promise towards highly integrated and robust detection tools and liquid handling. This perspective provides an overview of emergence of thin film optical waveguides used for evanes-cent field sensing of liquid chemical and biological samples for MIR absorption spectroscopy. The state of the art of new material and waveguide systems used for spectroscopic measurements in the MIR is presented. An outlook on the ad-vantages and future of waveguide-based MIR spectroscopy for application in clinical settings for point-of-care biochemical analysis is discussed.
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Accepted/In Press date: 13 July 2020
e-pub ahead of print date: 28 July 2020
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Local EPrints ID: 442942
URI: http://eprints.soton.ac.uk/id/eprint/442942
ISSN: 0003-2700
PURE UUID: 351dd988-bd9f-48cd-bce4-ea154cb0df0b
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Date deposited: 03 Aug 2020 16:49
Last modified: 10 Jan 2022 05:28
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Vinita Mittal
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