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Biofilm formation in periprosthetic joint infections

Biofilm formation in periprosthetic joint infections
Biofilm formation in periprosthetic joint infections
Formation of microbial biofilms has long been implicated in the occurrence of Periprosthetic Joint infections (PJIs). Despite the widespread acknowledgment of the severity of these infections, much is still unknown regarding the underlying mechanisms of biofilm establishment and proliferation in the joint space. The presence of these resilient, complex communities poses many clinical challenges with respect to prevention, diagnosis, and treatment practices. Mature biofilms are known to be highly recalcitrant to antibiotic therapeutics as well as host immune system mediated clearance. A comprehensive understanding of biofilms in the unique joint environment at the molecular level will provide clinicians valuable insight into how best to combat them. As each stage in the process of biofilm establishment has the potential for clinical intervention, this review will provide a sequential analysis of the existing literature, following each step in the formation cycle. New insights into bacterial survival mechanisms from antimicrobial challenge and host immune defenses will be discussed. These new observations in the field may shed light on the early protection conferred upon entry into the joint space ultimately leading to the establishment of a mature biofilm. Additionally, standards of clinical diagnosis as well as current measures of prevention and treatment will be briefly discussed.
Biofilm, PJI, Orthopedics, Treatment, Diagnostics
1-10
Staats, Amelia
ddd60847-7abf-43c1-a933-60b1abcec2bb
Li, Daniel
216db1e1-42cd-487c-9f31-65321d6c4c66
Sullivan, Anne
2fc4e087-c92c-405d-9071-18d5873b4cbd
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Staats, Amelia
ddd60847-7abf-43c1-a933-60b1abcec2bb
Li, Daniel
216db1e1-42cd-487c-9f31-65321d6c4c66
Sullivan, Anne
2fc4e087-c92c-405d-9071-18d5873b4cbd
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f

Staats, Amelia, Li, Daniel, Sullivan, Anne and Stoodley, Paul (2020) Biofilm formation in periprosthetic joint infections. The Annals of Joint, 1-10. (doi:10.21037/aoj-20-85). (In Press)

Record type: Article

Abstract

Formation of microbial biofilms has long been implicated in the occurrence of Periprosthetic Joint infections (PJIs). Despite the widespread acknowledgment of the severity of these infections, much is still unknown regarding the underlying mechanisms of biofilm establishment and proliferation in the joint space. The presence of these resilient, complex communities poses many clinical challenges with respect to prevention, diagnosis, and treatment practices. Mature biofilms are known to be highly recalcitrant to antibiotic therapeutics as well as host immune system mediated clearance. A comprehensive understanding of biofilms in the unique joint environment at the molecular level will provide clinicians valuable insight into how best to combat them. As each stage in the process of biofilm establishment has the potential for clinical intervention, this review will provide a sequential analysis of the existing literature, following each step in the formation cycle. New insights into bacterial survival mechanisms from antimicrobial challenge and host immune defenses will be discussed. These new observations in the field may shed light on the early protection conferred upon entry into the joint space ultimately leading to the establishment of a mature biofilm. Additionally, standards of clinical diagnosis as well as current measures of prevention and treatment will be briefly discussed.

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7-21-20-Biofilm formation PJI manuscript AOJ Revised - Accepted Manuscript
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More information

Accepted/In Press date: 24 July 2020
Keywords: Biofilm, PJI, Orthopedics, Treatment, Diagnostics

Identifiers

Local EPrints ID: 443061
URI: http://eprints.soton.ac.uk/id/eprint/443061
PURE UUID: c3c286f9-bf26-40b6-a1a1-91464ea3ece7
ORCID for Paul Stoodley: ORCID iD orcid.org/0000-0001-6069-273X

Catalogue record

Date deposited: 07 Aug 2020 16:36
Last modified: 13 Dec 2021 06:11

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Contributors

Author: Amelia Staats
Author: Daniel Li
Author: Anne Sullivan
Author: Paul Stoodley ORCID iD

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