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Birth weight, childhood and adolescent growth and diabetes risk factors in 21-year old Asian Indians: The Pune Children’s Study

Birth weight, childhood and adolescent growth and diabetes risk factors in 21-year old Asian Indians: The Pune Children’s Study
Birth weight, childhood and adolescent growth and diabetes risk factors in 21-year old Asian Indians: The Pune Children’s Study
Our objective was to investigate associations of body size (birth weight and body mass index (BMI)) and growth in height, body fat (adiposity) and lean mass during childhood and adolescence, with risk markers for diabetes in young South Asian adults. We studied 357 men and women aged 21 years from the Pune Children’s Study birth cohort. Exposures were 1) birth weight, 21-year BMI, both of these mutually adjusted, and their interaction, and 2) uncorrelated conditional measures of growth in height and proxies for gain in adiposity and lean mass from birth to 8 years (childhood) and 8 to 21 years (adolescence) constructed from birth weight, and weight, height, and skinfolds at 8 and 21 years. Outcomes were plasma glucose and insulin concentrations during an oral glucose tolerance test and derived indices of insulin resistance and secretion. Higher 21-year BMI was associated with higher glucose and insulin concentrations and insulin resistance, and lower disposition index. After adjusting for 21-year BMI, higher birth weight was associated with lower 120-min glucose and insulin resistance, and higher disposition index. In the growth analysis, greater adiposity gain during childhood and adolescence was associated with higher glucose, insulin and insulin resistance, and lower disposition index, with stronger effects from adolescent gain. Greater childhood lean gain and adolescent height gain were associated with lower 120-min glucose and insulin. Consistent with other studies, lower birth weight and higher childhood weight gain increases diabetes risk. Disaggregation of weight gain showed that greater child/adolescent adiposity gain and lower lean and height gain may increase risk.
Birth weight, India, child/adolescent body composition, diabetes risk, glucose-insulin metabolism
Kumaran, Kalyanaraman
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Lubree, Himangi
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Bhat, Dattatray S.
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Joshi, Suyog
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Joglekar, Charudatta V.
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Yajnik, Pallavi
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Bhave, Sheila A.
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Pandit, Anand N.
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Fall, Caroline H.D.
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Yajnik, Chittaranjan S.
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Kumaran, Kalyanaraman
de6f872c-7339-4a52-be84-e3bbae707744
Lubree, Himangi
47b67127-9784-4627-bba2-b7ef62ef0392
Bhat, Dattatray S.
b3b571d2-72af-4d0f-8cfd-5ec82733147f
Joshi, Suyog
3f722c3b-0da0-4740-83fb-2e9ac0d0a96c
Joglekar, Charudatta V.
eda2bdf9-acdc-472a-8703-57450afc7f31
Yajnik, Pallavi
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Bhave, Sheila A.
15b5d9ae-4a56-4d9a-a8fd-70353d8de978
Pandit, Anand N.
1f7497a8-c229-42bd-84bb-179b874483a5
Fall, Caroline H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Yajnik, Chittaranjan S.
f5777038-bba7-49bd-80b9-be4e586eecf4

Kumaran, Kalyanaraman, Lubree, Himangi, Bhat, Dattatray S., Joshi, Suyog, Joglekar, Charudatta V., Yajnik, Pallavi, Bhave, Sheila A., Pandit, Anand N., Fall, Caroline H.D. and Yajnik, Chittaranjan S. (2020) Birth weight, childhood and adolescent growth and diabetes risk factors in 21-year old Asian Indians: The Pune Children’s Study. Journal of the Developmental Origins of Health and Disease. (doi:10.1017/S2040174420000707).

Record type: Article

Abstract

Our objective was to investigate associations of body size (birth weight and body mass index (BMI)) and growth in height, body fat (adiposity) and lean mass during childhood and adolescence, with risk markers for diabetes in young South Asian adults. We studied 357 men and women aged 21 years from the Pune Children’s Study birth cohort. Exposures were 1) birth weight, 21-year BMI, both of these mutually adjusted, and their interaction, and 2) uncorrelated conditional measures of growth in height and proxies for gain in adiposity and lean mass from birth to 8 years (childhood) and 8 to 21 years (adolescence) constructed from birth weight, and weight, height, and skinfolds at 8 and 21 years. Outcomes were plasma glucose and insulin concentrations during an oral glucose tolerance test and derived indices of insulin resistance and secretion. Higher 21-year BMI was associated with higher glucose and insulin concentrations and insulin resistance, and lower disposition index. After adjusting for 21-year BMI, higher birth weight was associated with lower 120-min glucose and insulin resistance, and higher disposition index. In the growth analysis, greater adiposity gain during childhood and adolescence was associated with higher glucose, insulin and insulin resistance, and lower disposition index, with stronger effects from adolescent gain. Greater childhood lean gain and adolescent height gain were associated with lower 120-min glucose and insulin. Consistent with other studies, lower birth weight and higher childhood weight gain increases diabetes risk. Disaggregation of weight gain showed that greater child/adolescent adiposity gain and lower lean and height gain may increase risk.

Text
KK HL et al Pune Children's Study Main Paper Text Final for JDOHAD_Revised_Resubmission_Final_250620 - Accepted Manuscript
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Accepted/In Press date: 29 June 2020
e-pub ahead of print date: 5 August 2020
Keywords: Birth weight, India, child/adolescent body composition, diabetes risk, glucose-insulin metabolism

Identifiers

Local EPrints ID: 443382
URI: http://eprints.soton.ac.uk/id/eprint/443382
PURE UUID: 3d193ec3-7ef8-4b82-b02b-32ea702a623f
ORCID for Caroline H.D. Fall: ORCID iD orcid.org/0000-0003-4402-5552

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Date deposited: 24 Aug 2020 16:30
Last modified: 28 Apr 2022 05:15

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Contributors

Author: Himangi Lubree
Author: Dattatray S. Bhat
Author: Suyog Joshi
Author: Charudatta V. Joglekar
Author: Pallavi Yajnik
Author: Sheila A. Bhave
Author: Anand N. Pandit
Author: Chittaranjan S. Yajnik

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