Systematic Review and Meta-analysis: Resting-State Functional Magnetic Resonance Imaging Studies of Attention-Deficit/Hyperactivity Disorder
Systematic Review and Meta-analysis: Resting-State Functional Magnetic Resonance Imaging Studies of Attention-Deficit/Hyperactivity Disorder
Objective: To conduct a meta-analysis of resting-state functional magnetic resonance imaging (R-fMRI) studies in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and in adults with ADHD to assess spatial convergence of findings from available studies. Method: Based on a preregistered protocol in PROSPERO (CRD42019119553), a large set of databases were searched up to April 9, 2019, with no language or article type restrictions. Study authors were systematically contacted for additional unpublished information/data. Resting-state functional magnetic resonance imaging studies using seed-based connectivity (SBC) or any other method (non-SBC) reporting whole-brain results of group comparisons between participants with ADHD and typically developing controls were eligible. Voxelwise meta-analysis via activation likelihood estimation with cluster-level familywise error (voxel-level: p < .001; cluster-level: p < .05) was used. Results: Thirty studies (18 SBC and 12 non-SBC), comprising 1,978 participants (1,094 with ADHD; 884 controls) were retained. The meta-analysis focused on SBC studies found no significant spatial convergence of ADHD-related hyperconnectivity or hypoconnectivity across studies. This nonsignificant finding remained after integrating 12 non-SBC studies into the main analysis and in sensitivity analyses limited to studies including only children or only non–medication-naïve patients. Conclusion: The lack of significant spatial convergence may be accounted for by heterogeneity in study participants, experimental procedures, and analytic flexibility as well as in ADHD pathophysiology. Alongside other neuroimaging meta-analyses in other psychiatric conditions, the present results should inform the conduct and publication of future neuroimaging studies of psychiatric disorders.
ADHD, ALE, meta-analysis, neuroimaging, resting state
61-75
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Aoki, Yuta
806ea614-51b3-4018-b68b-d12b7f1487c1
Itahashi, Takashi
63261f90-3426-46cd-ac54-db65ed42a522
Castellanos, Xavier
d7451c60-1060-4558-bd6a-91ebf1273995
Eickhoff, Simon
675fb9f4-e560-481c-8e87-20a5215c20e8
1 January 2021
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Aoki, Yuta
806ea614-51b3-4018-b68b-d12b7f1487c1
Itahashi, Takashi
63261f90-3426-46cd-ac54-db65ed42a522
Castellanos, Xavier
d7451c60-1060-4558-bd6a-91ebf1273995
Eickhoff, Simon
675fb9f4-e560-481c-8e87-20a5215c20e8
Cortese, Samuele, Aoki, Yuta, Itahashi, Takashi, Castellanos, Xavier and Eickhoff, Simon
(2021)
Systematic Review and Meta-analysis: Resting-State Functional Magnetic Resonance Imaging Studies of Attention-Deficit/Hyperactivity Disorder.
Journal of the American Academy of Child and Adolescent Psychiatry, 60 (1), .
(doi:10.1016/j.jaac.2020.08.014).
Abstract
Objective: To conduct a meta-analysis of resting-state functional magnetic resonance imaging (R-fMRI) studies in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and in adults with ADHD to assess spatial convergence of findings from available studies. Method: Based on a preregistered protocol in PROSPERO (CRD42019119553), a large set of databases were searched up to April 9, 2019, with no language or article type restrictions. Study authors were systematically contacted for additional unpublished information/data. Resting-state functional magnetic resonance imaging studies using seed-based connectivity (SBC) or any other method (non-SBC) reporting whole-brain results of group comparisons between participants with ADHD and typically developing controls were eligible. Voxelwise meta-analysis via activation likelihood estimation with cluster-level familywise error (voxel-level: p < .001; cluster-level: p < .05) was used. Results: Thirty studies (18 SBC and 12 non-SBC), comprising 1,978 participants (1,094 with ADHD; 884 controls) were retained. The meta-analysis focused on SBC studies found no significant spatial convergence of ADHD-related hyperconnectivity or hypoconnectivity across studies. This nonsignificant finding remained after integrating 12 non-SBC studies into the main analysis and in sensitivity analyses limited to studies including only children or only non–medication-naïve patients. Conclusion: The lack of significant spatial convergence may be accounted for by heterogeneity in study participants, experimental procedures, and analytic flexibility as well as in ADHD pathophysiology. Alongside other neuroimaging meta-analyses in other psychiatric conditions, the present results should inform the conduct and publication of future neuroimaging studies of psychiatric disorders.
Text
Cortese_Aoki_et al_JAACAP_2020_accepted
- Accepted Manuscript
More information
Accepted/In Press date: 28 August 2020
e-pub ahead of print date: 15 September 2020
Published date: 1 January 2021
Additional Information:
Funding Information:
This work was partially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (grant number 18K15493 to Y.Y.A. and grant numbers 19K03370 and 19H04883 to T.I.), the Takeda Science Foundation (to Y.Y.A.), the SENSHIN Medical Research Foundation (to Y.Y.A.), the Deutsche Forschungsgemeinschaft (DFG; grant number EI 816/11-1), the National Institute of Mental Health (NIMH; grant number R01-MH074457), the Helmholtz Portfolio Theme ?Supercomputing and Modeling for the Human Brain,? and the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 945539 (HBP SGA3) (to S.B.E.) and R61MH113663 (to F.X.C.). Disclosure: Dr. Cortese has served as deputy editor of Evidence-Based Mental Health, as associate editor of Child and Adolescent Mental Health, and on the editorial boards of the Journal of Child Psychology and Psychiatry, the Journal of Child and Adolescent Psychopharmacology, and CNS Drugs. He has received honoraria for talks on ADHD from the Association for Child and Adolescent Mental Health, the British Association for Psychopharmacology, the Canadian ADHD Resource Alliance, and the Healthcare Convention. Dr. Castellanos has served as a member of the scientific advisory council for BOL Pharma, Israel. Drs. Aoki, Itahashi, and Eickhoff have reported no biomedical financial interests or potential conflicts of interest.
Funding Information:
This work was partially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (grant number 18K15493 to Y.Y.A. and grant numbers 19K03370 and 19H04883 to T.I.), the Takeda Science Foundation (to Y.Y.A.), the SENSHIN Medical Research Foundation (to Y.Y.A.), the Deutsche Forschungsgemeinschaft (DFG; grant number EI 816/11-1), the National Institute of Mental Health (NIMH; grant number R01-MH074457), the Helmholtz Portfolio Theme “Supercomputing and Modeling for the Human Brain,” and the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 945539 (HBP SGA3) (to S.B.E.) and R61MH113663 (to F.X.C.).
Publisher Copyright:
© 2020 The Authors
Keywords:
ADHD, ALE, meta-analysis, neuroimaging, resting state
Identifiers
Local EPrints ID: 443777
URI: http://eprints.soton.ac.uk/id/eprint/443777
ISSN: 1527-5418
PURE UUID: 8ab9dc14-2634-45e8-bc33-ad37013a3893
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Date deposited: 11 Sep 2020 16:30
Last modified: 17 Mar 2024 05:52
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Contributors
Author:
Yuta Aoki
Author:
Takashi Itahashi
Author:
Xavier Castellanos
Author:
Simon Eickhoff
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