The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The LifeCycle Project‑EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

The LifeCycle Project‑EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
The LifeCycle Project‑EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also provides a novel model for collaborative research in large research infrastructures with individual-level data. The LifeCycle Project will translate results from research using the EU Child Cohort Network into recommendations for targeted prevention strategies to improve health trajectories for current and future generations by optimizing their earliest phases of life.
0393-2990
709–724
Jaddoe, Vincent W V
9a192cd2-9c0c-4d34-ad24-c6c4162e7b05
Felix, Janine F.
fcd2dff7-ebdf-40b3-8714-eeba5fa4818a
Nybo Andersen, Anne-Marie
bbfdf744-9e94-44b1-b11c-07146454282f
Charles, Marie Aline
6258c9d7-9d1f-4717-abbf-23233e345946
Chatzi, Leda
d120a7e6-1fe3-4ce9-8b2b-55ad9aa1c254
Corpeleijn, Eva
05909036-7f7f-4296-89f2-7a005feb5460
Donner, Nina
69356991-de86-4210-8f65-d67f82d9c0b1
Elhakeem, Ahmed
f9bced1c-9287-4a5e-b892-17998dc6ac88
Eriksson, Johan
bed81786-e72a-4710-a5b7-ddc6732bc45a
Foong, Rachel
d84e56b8-1f17-423e-b886-ef0f3e60b5de
Grote, Veit
9962d399-4c9f-4bf6-afa2-460f0d6dcd60
Haakma, Sido
6f53ab9b-8875-48f0-8251-f696eb05a98c
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Harris, Jennifer R.
0a1ceb24-211f-41f1-9a57-e5f25bb042db
Heude, Barbara
a3d371f1-f044-4a08-aa83-80564ac0e1e3
Huang, Rai-Che
35feb26e-2fb0-4224-984f-38b293b01487
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Jarvelin, Marjo-Ritta
693bfe10-47a0-4b6f-8cf2-fcb8f764e137
Koletzko, Berthold
f3d6a0a1-bcda-4d80-aafe-f6fcd2d42c46
Lawlor, Debbie A.
799826df-f115-4fb7-83ea-53c246c220d4
Lindeboom, Maarten
6fe14b23-551c-4456-913d-ec7b8d2dde0a
McEachan, Rosemary
ed061aeb-3f0e-4b38-9035-885c4f598f54
Mikkola, Tuija M.
d39a9c20-54fb-4e67-9289-ffb91a2796f8
Nader, Johanna
fe2d6843-1b07-47b4-a9b2-082143be7097
Pinot de Moira, Angela
d747b110-0b6e-4dcf-a240-0a641cc498ca
Pizzi, Costanza
ee3b01b2-bff3-4b08-8113-79e263301dd3
Richiardi, Lorenzo
0c63927b-1f23-476a-860f-513460d29d31
Sebert, Sylvain
d3f6c0f7-92b9-4959-a86c-9f7ad3346ee3
Schwalber, Amelie
4fd50bd4-8d9e-4e55-ae28-6063344b56f5
Sunyer, Jordi
d795b752-79fd-450c-814a-fc342e3b8efa
Swertz, Morris A.
c53c0555-6fd7-4042-85fa-3bf269202917
Vafeiadi, Marina
8bfc9c8f-9876-48fb-bdd0-cf6695efeea0
Vrijheid, Martine
74022e9a-2b23-418f-b66d-8165926feef0
Wright, John
5d3dba6c-c81f-4393-8b28-d4195e9efefa
Duijts, Liesbeth
9af3d956-5a40-4cd7-badd-542639c84460
LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group
Jaddoe, Vincent W V
9a192cd2-9c0c-4d34-ad24-c6c4162e7b05
Felix, Janine F.
fcd2dff7-ebdf-40b3-8714-eeba5fa4818a
Nybo Andersen, Anne-Marie
bbfdf744-9e94-44b1-b11c-07146454282f
Charles, Marie Aline
6258c9d7-9d1f-4717-abbf-23233e345946
Chatzi, Leda
d120a7e6-1fe3-4ce9-8b2b-55ad9aa1c254
Corpeleijn, Eva
05909036-7f7f-4296-89f2-7a005feb5460
Donner, Nina
69356991-de86-4210-8f65-d67f82d9c0b1
Elhakeem, Ahmed
f9bced1c-9287-4a5e-b892-17998dc6ac88
Eriksson, Johan
bed81786-e72a-4710-a5b7-ddc6732bc45a
Foong, Rachel
d84e56b8-1f17-423e-b886-ef0f3e60b5de
Grote, Veit
9962d399-4c9f-4bf6-afa2-460f0d6dcd60
Haakma, Sido
6f53ab9b-8875-48f0-8251-f696eb05a98c
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Harris, Jennifer R.
0a1ceb24-211f-41f1-9a57-e5f25bb042db
Heude, Barbara
a3d371f1-f044-4a08-aa83-80564ac0e1e3
Huang, Rai-Che
35feb26e-2fb0-4224-984f-38b293b01487
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Jarvelin, Marjo-Ritta
693bfe10-47a0-4b6f-8cf2-fcb8f764e137
Koletzko, Berthold
f3d6a0a1-bcda-4d80-aafe-f6fcd2d42c46
Lawlor, Debbie A.
799826df-f115-4fb7-83ea-53c246c220d4
Lindeboom, Maarten
6fe14b23-551c-4456-913d-ec7b8d2dde0a
McEachan, Rosemary
ed061aeb-3f0e-4b38-9035-885c4f598f54
Mikkola, Tuija M.
d39a9c20-54fb-4e67-9289-ffb91a2796f8
Nader, Johanna
fe2d6843-1b07-47b4-a9b2-082143be7097
Pinot de Moira, Angela
d747b110-0b6e-4dcf-a240-0a641cc498ca
Pizzi, Costanza
ee3b01b2-bff3-4b08-8113-79e263301dd3
Richiardi, Lorenzo
0c63927b-1f23-476a-860f-513460d29d31
Sebert, Sylvain
d3f6c0f7-92b9-4959-a86c-9f7ad3346ee3
Schwalber, Amelie
4fd50bd4-8d9e-4e55-ae28-6063344b56f5
Sunyer, Jordi
d795b752-79fd-450c-814a-fc342e3b8efa
Swertz, Morris A.
c53c0555-6fd7-4042-85fa-3bf269202917
Vafeiadi, Marina
8bfc9c8f-9876-48fb-bdd0-cf6695efeea0
Vrijheid, Martine
74022e9a-2b23-418f-b66d-8165926feef0
Wright, John
5d3dba6c-c81f-4393-8b28-d4195e9efefa
Duijts, Liesbeth
9af3d956-5a40-4cd7-badd-542639c84460

Jaddoe, Vincent W V, Felix, Janine F., Nybo Andersen, Anne-Marie, Charles, Marie Aline, Chatzi, Leda, Corpeleijn, Eva, Donner, Nina, Elhakeem, Ahmed, Eriksson, Johan, Foong, Rachel, Grote, Veit, Haakma, Sido, Hanson, Mark, Harris, Jennifer R., Heude, Barbara, Huang, Rai-Che, Inskip, Hazel, Jarvelin, Marjo-Ritta, Koletzko, Berthold, Lawlor, Debbie A., Lindeboom, Maarten, McEachan, Rosemary, Mikkola, Tuija M., Nader, Johanna, Pinot de Moira, Angela, Pizzi, Costanza, Richiardi, Lorenzo, Sebert, Sylvain, Schwalber, Amelie, Sunyer, Jordi, Swertz, Morris A., Vafeiadi, Marina, Vrijheid, Martine, Wright, John and Duijts, Liesbeth , LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group (2020) The LifeCycle Project‑EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents. European Journal of Epidemiology, 35, 709–724. (doi:10.1007/s10654-020-00662-z).

Record type: Article

Abstract

Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also provides a novel model for collaborative research in large research infrastructures with individual-level data. The LifeCycle Project will translate results from research using the EU Child Cohort Network into recommendations for targeted prevention strategies to improve health trajectories for current and future generations by optimizing their earliest phases of life.

Text
20200629 Consortium Design Complete - Accepted Manuscript
Download (594kB)

More information

Accepted/In Press date: 4 July 2020
e-pub ahead of print date: 23 July 2020

Identifiers

Local EPrints ID: 443855
URI: http://eprints.soton.ac.uk/id/eprint/443855
ISSN: 0393-2990
PURE UUID: 803e3538-7108-4d47-99ae-488402682d9d
ORCID for Mark Hanson: ORCID iD orcid.org/0000-0002-6907-613X
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749

Catalogue record

Date deposited: 15 Sep 2020 16:30
Last modified: 09 Oct 2021 04:01

Export record

Altmetrics

Contributors

Author: Vincent W V Jaddoe
Author: Janine F. Felix
Author: Anne-Marie Nybo Andersen
Author: Marie Aline Charles
Author: Leda Chatzi
Author: Eva Corpeleijn
Author: Nina Donner
Author: Ahmed Elhakeem
Author: Johan Eriksson
Author: Rachel Foong
Author: Veit Grote
Author: Sido Haakma
Author: Mark Hanson ORCID iD
Author: Jennifer R. Harris
Author: Barbara Heude
Author: Rai-Che Huang
Author: Hazel Inskip ORCID iD
Author: Marjo-Ritta Jarvelin
Author: Berthold Koletzko
Author: Debbie A. Lawlor
Author: Maarten Lindeboom
Author: Rosemary McEachan
Author: Tuija M. Mikkola
Author: Johanna Nader
Author: Angela Pinot de Moira
Author: Costanza Pizzi
Author: Lorenzo Richiardi
Author: Sylvain Sebert
Author: Amelie Schwalber
Author: Jordi Sunyer
Author: Morris A. Swertz
Author: Marina Vafeiadi
Author: Martine Vrijheid
Author: John Wright
Author: Liesbeth Duijts
Corporate Author: LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×