Risk and protective factors for mental disorders with onset in childhood/adolescence: an umbrella review of published meta-analyses of observational longitudinal studies
Risk and protective factors for mental disorders with onset in childhood/adolescence: an umbrella review of published meta-analyses of observational longitudinal studies
The patho-etiology of mental disorders with onset in childhood or adolescence remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases, last search April 29th, 2020. Quality of MAs was measured with AMSTAR-2. Out of 6851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium or antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. Quality of meta-analyses was rated as high in two, moderate in one, low in four, critically low in two, and not pertinent in one (individual participant data). Methodologically-sound research is needed in this field.
Adolescence, Childhood, Mental health, Meta-analysis, Neurodevelopmental, Prevention, Risk factor, Systematic review, umbrella review
Solmi, Marco
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Dragioti, Elena
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Arango, Celso
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Radua, Jouaquim
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Ostinelli, Edoardo
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Kilic, Ozge
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Ylmaz, Ugur Eser
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Yalcinay-İnan, Merve
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Soarez, Fernanda Cunha
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Mariano, Luca
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Mosillo, Pierluca
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Cortese, Samuele
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Correll, Christoph
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Carvalho, Andre
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Shin, Jae II
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Fusar-Poli, Paolo
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Solmi, Marco
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Dragioti, Elena
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Arango, Celso
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Radua, Jouaquim
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Ostinelli, Edoardo
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Kilic, Ozge
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Ylmaz, Ugur Eser
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Yalcinay-İnan, Merve
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Soarez, Fernanda Cunha
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Mariano, Luca
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Mosillo, Pierluca
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Cortese, Samuele
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Correll, Christoph
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Carvalho, Andre
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Shin, Jae II
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Fusar-Poli, Paolo
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Solmi, Marco, Dragioti, Elena, Arango, Celso, Radua, Jouaquim, Ostinelli, Edoardo, Kilic, Ozge, Ylmaz, Ugur Eser, Yalcinay-İnan, Merve, Soarez, Fernanda Cunha, Mariano, Luca, Mosillo, Pierluca, Cortese, Samuele, Correll, Christoph, Carvalho, Andre, Shin, Jae II and Fusar-Poli, Paolo
(2020)
Risk and protective factors for mental disorders with onset in childhood/adolescence: an umbrella review of published meta-analyses of observational longitudinal studies.
Neuroscience and Behavioral Reviews.
(doi:10.1016/j.neubiorev.2020.09.002).
Abstract
The patho-etiology of mental disorders with onset in childhood or adolescence remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases, last search April 29th, 2020. Quality of MAs was measured with AMSTAR-2. Out of 6851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium or antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. Quality of meta-analyses was rated as high in two, moderate in one, low in four, critically low in two, and not pertinent in one (individual participant data). Methodologically-sound research is needed in this field.
Text
Manuscript_Neurodevelopmental_risk_ur_NBR
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Accepted/In Press date: 4 September 2020
e-pub ahead of print date: 12 September 2020
Additional Information:
Funding Information:
CUC has been a consultant and/or advisor to or have received honoraria from: Alkermes, Allergan, Angelini, Boehringer-Ingelheim, Gedeon Richter, Gerson Lehrman Group, Indivior, IntraCellular Therapies, Janssen/J&J, LB Pharma, Lundbeck, MedAvante-ProPhase, Medscape, Merck, Neurocrine, Noven, Otsuka, Pfizer, Recordati, Rovi, Servier, Sumitomo Dainippon, Sunovion, Supernus, Takeda, and Teva. He provided expert testimony for Janssen and Otsuka. He served on a Data Safety Monitoring Board for Lundbeck, Rovi, Supernus, and Teva. He has received grant support from Janssen and Takeda. He is also a stock option holder of LB Pharma.
Funding Information:
CA is supported by the S panish Ministry of Science and Innovation . Instituto de Salud Carlos III ( SAM16PE07CP1, PI16/02012, PI19/024) , co-financed by ERDF Funds from the European Commission, “A way of making Europe”, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds. European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement No 115916 , Project PRISM, and grant agreement No 777394 , Project AIMS-2-TRIALS), Fundación Familia Alonso and Fundación Alicia Koplowitz.
Publisher Copyright:
© 2020 Elsevier Ltd
Keywords:
Adolescence, Childhood, Mental health, Meta-analysis, Neurodevelopmental, Prevention, Risk factor, Systematic review, umbrella review
Identifiers
Local EPrints ID: 443912
URI: http://eprints.soton.ac.uk/id/eprint/443912
ISSN: 0097-0549
PURE UUID: 4feade32-e5ed-45c0-9457-0c9da5b56391
Catalogue record
Date deposited: 16 Sep 2020 16:35
Last modified: 17 Mar 2024 05:54
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Contributors
Author:
Marco Solmi
Author:
Elena Dragioti
Author:
Celso Arango
Author:
Jouaquim Radua
Author:
Edoardo Ostinelli
Author:
Ozge Kilic
Author:
Ugur Eser Ylmaz
Author:
Merve Yalcinay-İnan
Author:
Fernanda Cunha Soarez
Author:
Luca Mariano
Author:
Pierluca Mosillo
Author:
Christoph Correll
Author:
Andre Carvalho
Author:
Jae II Shin
Author:
Paolo Fusar-Poli
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