Poor bone quality is associated with greater arterial stiffness: insights from the UK biobank

Accepted/In Press date: 5 August 2020

e-pub ahead of print date: 22 September 2020

Published date: 19 January 2021

Additional Information: Funding Information: This work was supported by UK Medical Research Council (4050502589 [MRC LEU]); British Heart Foundation; Arthritis Research UK; Royal Osteoporosis Society Osteoporosis and Bone Research Academy; International Osteoporosis Foundation; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust; National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford; and National Institute for Health Research Cardiovascular Biomedical Research Unit at Barts. EMC is supported by the Wellcome Trust and National Institute for Health Research. This research has been conducted using the UK Biobank Resource (access reference 2964). NA and MMS recognize the National Institute for Health Research (NIHR) Integrated Academic Training programme, which supports their Academic Clinical Lectureship and Academic Clinical Fellowship posts, respectively. Authors' roles: All authors contributed to preparation and final approval of the manuscript. ZRE, NCH, EMC, JP, and SEP led the initial project and drafting; ZRE and JC undertook statistical analysis; LB performed aortic distensibility analysis, image quality control, and supervised the validation of automated results; NA, KF, EL, EH, JMP, MMS, and RJT performed manual validation of aortic distensibility results; NCH/SEP oversaw the project and are guarantors. Author contributions: Zahra Raisi-Estabragh: Conceptualization; formal analysis; investigation; methodology; visualization; writing-original draft; writing-review and editing. Luca Biasiolli: Data curation; writing-review and editing. Jackie Cooper: Formal analysis; investigation; methodology. Nay Aung: Data curation; writing-review and editing. Kenneth Fung: Data curation; writing-review and editing. Jose Paiva: Data curation; writing-review and editing. Mihir Sanghvi: Data curation; writing-review and editing. Ross Thomson: Data curation; writing-review and editing. Beth Curtis: Conceptualization; writing-review and editing. Julien Paccou: Writing-review and editing. Jennifer Rayner: Data curation; writing-review and editing. Konrad Werys: Data curation; writing-review and editing. Henrike Puchta: Data curation; writing-review and editing. Katharine E Tomas: Data curation; writing-review and editing. Aaron Lee: Data curation; writing-review and editing. Stefan Piechnik: Data curation; writing-review and editing. Stefan Neubauer: Data curation; writing-review and editing. Patricia Munroe: Supervision; writing-review and editing. Cyrus Cooper: Writing-review and editing. Steffen Petersen: Conceptualization; supervision; writing-original draft; writing-review and editing. Nicholas Harvey: Conceptualization; supervision; writing-original draft; writing-review and editing. Funding Information: ZRE is supported by British Heart Foundation Clinical Research Training Fellowship no. FS/17/81/33318. SEP acknowledges support from the National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Centre at Barts and he received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 825903. SEP, SN, and SKP acknowledge the British Heart Foundation for funding the manual analysis to create a cardiovascular magnetic resonance imaging reference standard for the UK Biobank imaging resource in 5000 CMR scans ( www.bhf.org.uk ; PG/14/89/31194). LB acknowledges the support of the British Heart Foundation (PG/15/74/31747). NA is supported by a Wellcome Trust Research Training Fellowship ( wellcome.ac.uk ; 203553/Z/Z). KF is supported by the Medical College of Saint Bartholomew's Hospital Trust, an independent registered charity that promotes and advances medical and dental education and research at Barts and The London School of Medicine and Dentistry. SEP and AML acknowledge support from the NIHR Biomedical Research Centre at Barts and from the “SmartHeart” EPSRC programme grant ( www.nihr.ac.uk ; EP/P001009/1). SN and SKP are supported by the Oxford NIHR Biomedical Research Centre and the Oxford British Heart Foundation Centre of Research Excellence. SEP acts as a paid consultant to Circle Cardiovascular Imaging Inc., Calgary, ON, Canada, and Servier. NCH has received consultancy, lecture fees, and honoraria from Alliance for Better Bone Health, Amgen, MSD, Eli Lilly, Servier, Shire, Radius Health, UCB, Consilient Healthcare, Kyowa Kirin, and Internis Pharma. CC has received consultancy, lecture fees, and honoraria from Amgen, GlaxoSmithKline, Alliance for Better Bone Health, Merck Sharp & Dohme, Eli Lilly, Pfizer, Novartis, Servier, Medtronic, and Roche. EC reports honoraria/travel support from Eli Lilly, UCB, Pfizer, and Amgen outside the submitted work. Funding Information: This work was supported by UK Medical Research Council (4050502589 [MRC LEU]); British Heart Foundation; Arthritis Research UK; Royal Osteoporosis Society Osteoporosis and Bone Research Academy; International Osteoporosis Foundation; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust; National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford; and National Institute for Health Research Cardiovascular Biomedical Research Unit at Barts. EMC is supported by the Wellcome Trust and National Institute for Health Research. This research has been conducted using the UK Biobank Resource (access reference 2964). NA and MMS recognize the National Institute for Health Research (NIHR) Integrated Academic Training programme, which supports their Academic Clinical Lectureship and Academic Clinical Fellowship posts, respectively. Publisher Copyright: © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

Keywords: ARTERIAL STIFFNESS, CARDIOVASCULAR DISEASE, EPIDEMIOLOGY, ISCHEMIC HEART DISEASE, OSTEOPOROSIS

Local EPrints ID: 444088

URI: http://eprints.soton.ac.uk/id/eprint/444088

DOI: doi:10.1002/jbmr.4164

ISSN: 0884-0431

PURE UUID: 9da0f397-d173-459f-9b1f-8e09c34d83b2

ORCID for Elizabeth Curtis: orcid.org/0000-0002-5147-0550

ORCID for Cyrus Cooper: orcid.org/0000-0003-3510-0709

ORCID for Nicholas C Harvey: orcid.org/0000-0002-8194-2512

Date deposited: 24 Sep 2020 16:44

Last modified: 18 Mar 2024 03:38