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Poor bone quality is associated with greater arterial stiffness: insights from the UK biobank

Poor bone quality is associated with greater arterial stiffness: insights from the UK biobank
Poor bone quality is associated with greater arterial stiffness: insights from the UK biobank
Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with a potentially causal relationship. In this study, we tested the association of bone speed of sound (SOS) from quantitative heel ultrasound with (i) measures of arterial compliance from cardiovascular magnetic resonance (aortic distensibility [AD]); (ii) finger photoplethysmography (arterial stiffness index [ASI]); and (iii) incident myocardial infarction and IHD mortality in the UK Biobank cohort. We considered the potential mediating effect of a range of blood biomarkers and cardiometabolic morbidities and evaluated differential relationships by sex, menopause status, smoking, diabetes, and obesity. Furthermore, we considered whether associations with arterial compliance explained association of SOS with ischemic cardiovascular outcomes. Higher SOS was associated with lower arterial compliance by both ASI and AD for both men and women. The relationship was most consistent with ASI, likely relating to larger sample size available for this variable (n = 159,542 versus n = 18,229). There was no clear evidence of differential relationship by menopause, smoking, diabetes, or body mass index (BMI). Blood biomarkers appeared important in mediating the association for both men and women, but with different directions of effect and did not fully explain the observed effects. In fully adjusted models, higher SOS was associated with significantly lower IHD mortality in men, but less robustly in women. The association of SOS with ASI did not explain this observation. In conclusion, our findings support a positive association between bone and vascular health with consistent patterns of association in men and women. The underlying mechanisms are complex and appear to vary by sex.
ARTERIAL STIFFNESS, CARDIOVASCULAR DISEASE, EPIDEMIOLOGY, ISCHEMIC HEART DISEASE, OSTEOPOROSIS
0884-0431
90-99
Raisi-Estabragh, Zahra
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Biasiolli, Luca
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Cooper, Jackie
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Aung, Nay
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Fung, Kenneth
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Paiva, José M.
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Sanghvi, Mihir M.
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Thomson, Ross J.
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Curtis, Elizabeth
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Paccou, Julien
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Rayner, Jennifer J.
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Werys, Konrad
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Puchta, Henrike
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Thomas, Katharine E.
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Lee, Aaron M.
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Piechnik, Stefan K.
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Neubauer, Stefan
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Munroe, Patricia B.
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Cooper, Cyrus
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Petersen, Steffen E.
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Harvey, Nicholas C
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Raisi-Estabragh, Zahra
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Biasiolli, Luca
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Cooper, Jackie
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Aung, Nay
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Fung, Kenneth
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Paiva, José M.
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Sanghvi, Mihir M.
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Thomson, Ross J.
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Curtis, Elizabeth
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Paccou, Julien
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Rayner, Jennifer J.
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Werys, Konrad
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Puchta, Henrike
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Thomas, Katharine E.
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Lee, Aaron M.
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Piechnik, Stefan K.
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Neubauer, Stefan
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Munroe, Patricia B.
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Cooper, Cyrus
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Petersen, Steffen E.
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Harvey, Nicholas C
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Raisi-Estabragh, Zahra, Biasiolli, Luca, Cooper, Jackie, Aung, Nay, Fung, Kenneth, Paiva, José M., Sanghvi, Mihir M., Thomson, Ross J., Curtis, Elizabeth, Paccou, Julien, Rayner, Jennifer J., Werys, Konrad, Puchta, Henrike, Thomas, Katharine E., Lee, Aaron M., Piechnik, Stefan K., Neubauer, Stefan, Munroe, Patricia B., Cooper, Cyrus, Petersen, Steffen E. and Harvey, Nicholas C (2021) Poor bone quality is associated with greater arterial stiffness: insights from the UK biobank. Journal of Bone and Mineral Research, 36 (1), 90-99. (doi:10.1002/jbmr.4164).

Record type: Article

Abstract

Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with a potentially causal relationship. In this study, we tested the association of bone speed of sound (SOS) from quantitative heel ultrasound with (i) measures of arterial compliance from cardiovascular magnetic resonance (aortic distensibility [AD]); (ii) finger photoplethysmography (arterial stiffness index [ASI]); and (iii) incident myocardial infarction and IHD mortality in the UK Biobank cohort. We considered the potential mediating effect of a range of blood biomarkers and cardiometabolic morbidities and evaluated differential relationships by sex, menopause status, smoking, diabetes, and obesity. Furthermore, we considered whether associations with arterial compliance explained association of SOS with ischemic cardiovascular outcomes. Higher SOS was associated with lower arterial compliance by both ASI and AD for both men and women. The relationship was most consistent with ASI, likely relating to larger sample size available for this variable (n = 159,542 versus n = 18,229). There was no clear evidence of differential relationship by menopause, smoking, diabetes, or body mass index (BMI). Blood biomarkers appeared important in mediating the association for both men and women, but with different directions of effect and did not fully explain the observed effects. In fully adjusted models, higher SOS was associated with significantly lower IHD mortality in men, but less robustly in women. The association of SOS with ASI did not explain this observation. In conclusion, our findings support a positive association between bone and vascular health with consistent patterns of association in men and women. The underlying mechanisms are complex and appear to vary by sex.

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Accepted/In Press date: 5 August 2020
e-pub ahead of print date: 22 September 2020
Published date: 19 January 2021
Keywords: ARTERIAL STIFFNESS, CARDIOVASCULAR DISEASE, EPIDEMIOLOGY, ISCHEMIC HEART DISEASE, OSTEOPOROSIS

Identifiers

Local EPrints ID: 444088
URI: http://eprints.soton.ac.uk/id/eprint/444088
ISSN: 0884-0431
PURE UUID: 9da0f397-d173-459f-9b1f-8e09c34d83b2
ORCID for Elizabeth Curtis: ORCID iD orcid.org/0000-0002-5147-0550
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Nicholas C Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 24 Sep 2020 16:44
Last modified: 26 Nov 2021 03:09

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Contributors

Author: Zahra Raisi-Estabragh
Author: Luca Biasiolli
Author: Jackie Cooper
Author: Nay Aung
Author: Kenneth Fung
Author: José M. Paiva
Author: Mihir M. Sanghvi
Author: Ross J. Thomson
Author: Julien Paccou
Author: Jennifer J. Rayner
Author: Konrad Werys
Author: Henrike Puchta
Author: Katharine E. Thomas
Author: Aaron M. Lee
Author: Stefan K. Piechnik
Author: Stefan Neubauer
Author: Patricia B. Munroe
Author: Cyrus Cooper ORCID iD
Author: Steffen E. Petersen

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