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A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema

A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema
A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema
Evidence is accumulating that the establishment of the gut microbiome in early life influences the development of atopic eczema. In this longitudinal study, we used integrated multi-omics analyses to infer functional mechanisms by which the microbiome modulates atopic eczema risk. We measured the functionality of the gut microbiome and metabolome of 63 infants between ages 3 weeks and 12 months with well-defined eczema cases and controls in a sub-cohort from the Growing Up in Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort. At 3 weeks, the microbiome and metabolome of allergen-sensitized atopic eczema infants were characterized by an enrichment of Escherichia coli and Klebsiella pneumoniae, associated with increased stool D-glucose concentration and increased gene expression of associated virulence factors. A delayed colonization by beneficial Bacteroides fragilis and subsequent delayed accumulation of butyrate and propionate producers after 3 months was also observed. Here, we describe an aberrant developmental trajectory of the gut microbiome and stool metabolome in allergen sensitized atopic eczema infants.
Early life, SCFA, allergen sensitization, atopic dermatitis, atopic eczema, gut metabolome, gut microbiome
1-21
Ta, Le Duc Huy
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Chan, James Chun Yip
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Yap, Gaik Chin
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Purbojati, Rikky W.
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Drautz-Moses, Daniela I.
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Koh, Yanqing Michelle
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Tay, Carina Jing Xuan
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Huang, Chiung-Hui
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Kioh, Dorinda Yan Qin
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Woon, Jia Yun
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Tham, Elizabeth Huiwen
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Loo, Evelyn Xiu-Ling
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Shek, Lynette P.
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Karnani, Neerja
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Goh, Anne
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van Bever, Hugo
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Teoh, Oon Hoe
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Chan, Yiong Huak
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Lay, Christophe
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Knol, Jan
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Yap, Fabian
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Tan, Kok Hian
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Chong, Yap-Seng
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Godfrey, Keith
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Kjelleberg, Staffan
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Schuster, Stephan C.
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Chan, Eric Chun Yong
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Lee, Bee Wah
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Ta, Le Duc Huy
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Chan, James Chun Yip
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Yap, Gaik Chin
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Purbojati, Rikky W.
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Drautz-Moses, Daniela I.
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Koh, Yanqing Michelle
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Tay, Carina Jing Xuan
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Huang, Chiung-Hui
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Kioh, Dorinda Yan Qin
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Woon, Jia Yun
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Tham, Elizabeth Huiwen
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Loo, Evelyn Xiu-Ling
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Shek, Lynette P.
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Karnani, Neerja
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Goh, Anne
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van Bever, Hugo
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Teoh, Oon Hoe
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Chan, Yiong Huak
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Lay, Christophe
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Knol, Jan
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Yap, Fabian
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Tan, Kok Hian
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Chong, Yap-Seng
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Godfrey, Keith
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Kjelleberg, Staffan
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Schuster, Stephan C.
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Chan, Eric Chun Yong
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Lee, Bee Wah
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Ta, Le Duc Huy, Chan, James Chun Yip, Yap, Gaik Chin, Purbojati, Rikky W., Drautz-Moses, Daniela I., Koh, Yanqing Michelle, Tay, Carina Jing Xuan, Huang, Chiung-Hui, Kioh, Dorinda Yan Qin, Woon, Jia Yun, Tham, Elizabeth Huiwen, Loo, Evelyn Xiu-Ling, Shek, Lynette P., Karnani, Neerja, Goh, Anne, van Bever, Hugo, Teoh, Oon Hoe, Chan, Yiong Huak, Lay, Christophe, Knol, Jan, Yap, Fabian, Tan, Kok Hian, Chong, Yap-Seng, Godfrey, Keith, Kjelleberg, Staffan, Schuster, Stephan C., Chan, Eric Chun Yong and Lee, Bee Wah (2020) A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema. Gut Microbes, 12 (1), 1-21. (doi:10.1080/19490976.2020.1801964).

Record type: Article

Abstract

Evidence is accumulating that the establishment of the gut microbiome in early life influences the development of atopic eczema. In this longitudinal study, we used integrated multi-omics analyses to infer functional mechanisms by which the microbiome modulates atopic eczema risk. We measured the functionality of the gut microbiome and metabolome of 63 infants between ages 3 weeks and 12 months with well-defined eczema cases and controls in a sub-cohort from the Growing Up in Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort. At 3 weeks, the microbiome and metabolome of allergen-sensitized atopic eczema infants were characterized by an enrichment of Escherichia coli and Klebsiella pneumoniae, associated with increased stool D-glucose concentration and increased gene expression of associated virulence factors. A delayed colonization by beneficial Bacteroides fragilis and subsequent delayed accumulation of butyrate and propionate producers after 3 months was also observed. Here, we describe an aberrant developmental trajectory of the gut microbiome and stool metabolome in allergen sensitized atopic eczema infants.

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Manuscript - Ta et al - Gut Microbes 080720 Final - Accepted Manuscript
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More information

Accepted/In Press date: 15 July 2020
e-pub ahead of print date: 6 October 2020
Keywords: Early life, SCFA, allergen sensitization, atopic dermatitis, atopic eczema, gut metabolome, gut microbiome

Identifiers

Local EPrints ID: 444583
URI: http://eprints.soton.ac.uk/id/eprint/444583
PURE UUID: 1e2eda46-479a-4d85-ba20-9169ec50a1eb
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 26 Oct 2020 17:32
Last modified: 26 Nov 2021 05:42

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Contributors

Author: Le Duc Huy Ta
Author: James Chun Yip Chan
Author: Gaik Chin Yap
Author: Rikky W. Purbojati
Author: Daniela I. Drautz-Moses
Author: Yanqing Michelle Koh
Author: Carina Jing Xuan Tay
Author: Chiung-Hui Huang
Author: Dorinda Yan Qin Kioh
Author: Jia Yun Woon
Author: Elizabeth Huiwen Tham
Author: Evelyn Xiu-Ling Loo
Author: Lynette P. Shek
Author: Neerja Karnani
Author: Anne Goh
Author: Hugo van Bever
Author: Oon Hoe Teoh
Author: Yiong Huak Chan
Author: Christophe Lay
Author: Jan Knol
Author: Fabian Yap
Author: Kok Hian Tan
Author: Yap-Seng Chong
Author: Keith Godfrey ORCID iD
Author: Staffan Kjelleberg
Author: Stephan C. Schuster
Author: Eric Chun Yong Chan
Author: Bee Wah Lee

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