Developing symptom lists for people with cancer treated with targeted therapies
Developing symptom lists for people with cancer treated with targeted therapies
Background: Targeted therapies (TTs) have revolutionised cancer treatment with their enhanced specificity of action. Compared with conventional therapies, TTs are delivered over a longer period and often have unusual symptom profiles. Patient-reported outcome measures such as symptom side-effect lists need to be developed in a time-efficient manner to enable a rapid and full evaluation of new treatments and effective clinical management Objective: The aim of this study was to develop a set of TT-related symptoms and identify the optimal method for developing symptom lists. Patients and Methods: Symptoms from TT treatment in the context of Chronic Myeloid Leukaemia (CML), HER2-positive breast cancer, or Gastrointestinal Stromal Tumours (GIST) were identified through literature reviews, interviews with healthcare professionals (HCPs) and patients, and patient focus groups. The symptom set was then pilot tested in patients across the three cancer diagnoses: The number of items derived from each source (literature, patients, or HCPs) were compared. Results: A total of 316 patients and 86 HCPs from 16 countries participated. An initial set of 209 symptoms was reduced to 61 covering 12 symptom categories. Patient interviews made the greatest contribution to the item set. Conclusions: Symptom lists should be created based on input from patients. The item set described will be applicable to the assessment of new TTs, and in monitoring treatment.
95–107
Sodergren, Samantha
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Wheelwright, Sally
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Fitzsimmons, Deborah
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Efficace, Fabio
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Sprangers, Mirjam
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Fayers, Peter
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Harle, Amelie
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Schmidt, Heike
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Bottomley, Andrew
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Darlington, Anne-Sophie
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Benson, Charlotte
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Bredart, Anne
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Hentschel, Leopold
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Arraras, Juan Ignacio
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Ioannidis, Georgios
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Leahy, Michael
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Lugowska, Iwona
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Nicolatou-Galitis, Ourania
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Petranovic, Duska
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Rohde, Gudrun E
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Vassiliou, Vasilis
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Johnson, Colin D.
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1 January 2021
Sodergren, Samantha
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Wheelwright, Sally
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Fitzsimmons, Deborah
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Efficace, Fabio
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Sprangers, Mirjam
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Fayers, Peter
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Harle, Amelie
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Schmidt, Heike
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Bottomley, Andrew
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Darlington, Anne-Sophie
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Benson, Charlotte
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Bredart, Anne
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Hentschel, Leopold
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Arraras, Juan Ignacio
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Ioannidis, Georgios
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Leahy, Michael
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Lugowska, Iwona
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Nicolatou-Galitis, Ourania
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Petranovic, Duska
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Rohde, Gudrun E
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Vassiliou, Vasilis
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Johnson, Colin D.
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Sodergren, Samantha, Wheelwright, Sally, Fitzsimmons, Deborah, Efficace, Fabio, Sprangers, Mirjam, Fayers, Peter, Harle, Amelie, Schmidt, Heike, Bottomley, Andrew, Darlington, Anne-Sophie, Benson, Charlotte, Bredart, Anne, Hentschel, Leopold, Arraras, Juan Ignacio, Ioannidis, Georgios, Leahy, Michael, Lugowska, Iwona, Nicolatou-Galitis, Ourania, Petranovic, Duska, Rohde, Gudrun E, Vassiliou, Vasilis and Johnson, Colin D.
(2021)
Developing symptom lists for people with cancer treated with targeted therapies.
Targeted Oncology, 16 (1), .
(doi:10.1007/s11523-020-00769-z).
Abstract
Background: Targeted therapies (TTs) have revolutionised cancer treatment with their enhanced specificity of action. Compared with conventional therapies, TTs are delivered over a longer period and often have unusual symptom profiles. Patient-reported outcome measures such as symptom side-effect lists need to be developed in a time-efficient manner to enable a rapid and full evaluation of new treatments and effective clinical management Objective: The aim of this study was to develop a set of TT-related symptoms and identify the optimal method for developing symptom lists. Patients and Methods: Symptoms from TT treatment in the context of Chronic Myeloid Leukaemia (CML), HER2-positive breast cancer, or Gastrointestinal Stromal Tumours (GIST) were identified through literature reviews, interviews with healthcare professionals (HCPs) and patients, and patient focus groups. The symptom set was then pilot tested in patients across the three cancer diagnoses: The number of items derived from each source (literature, patients, or HCPs) were compared. Results: A total of 316 patients and 86 HCPs from 16 countries participated. An initial set of 209 symptoms was reduced to 61 covering 12 symptom categories. Patient interviews made the greatest contribution to the item set. Conclusions: Symptom lists should be created based on input from patients. The item set described will be applicable to the assessment of new TTs, and in monitoring treatment.
Text
Developing symptom lists for people with cancer treated with targeted therapies
- Accepted Manuscript
More information
Accepted/In Press date: 7 October 2020
e-pub ahead of print date: 9 November 2020
Published date: 1 January 2021
Additional Information:
Funding Information:
Juan Ignacio Arraras received funding from “la Caixa” Foundation (ID 1000010434), Caja Navarra Foundation and UNED Pamplona, under agreement LCF/PR/PR15/51100007. The remaining authors declare that they have no conflicts of interest that might be relevant to the contents of this article.
Publisher Copyright:
© 2020, Springer Nature Switzerland AG.
Identifiers
Local EPrints ID: 444724
URI: http://eprints.soton.ac.uk/id/eprint/444724
ISSN: 1776-2596
PURE UUID: dc38e404-d721-4fed-a9be-40b82da41423
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Date deposited: 02 Nov 2020 17:31
Last modified: 17 Mar 2024 06:00
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Contributors
Author:
Deborah Fitzsimmons
Author:
Fabio Efficace
Author:
Mirjam Sprangers
Author:
Peter Fayers
Author:
Amelie Harle
Author:
Heike Schmidt
Author:
Andrew Bottomley
Author:
Charlotte Benson
Author:
Anne Bredart
Author:
Leopold Hentschel
Author:
Juan Ignacio Arraras
Author:
Georgios Ioannidis
Author:
Michael Leahy
Author:
Iwona Lugowska
Author:
Ourania Nicolatou-Galitis
Author:
Duska Petranovic
Author:
Gudrun E Rohde
Author:
Vasilis Vassiliou
Author:
Colin D. Johnson
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