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Developing symptom lists for people with cancer treated with targeted therapies

Developing symptom lists for people with cancer treated with targeted therapies
Developing symptom lists for people with cancer treated with targeted therapies
Background: Targeted Therapies (TTs) have revolutionised cancer treatment with their enhanced specificity of action. Compared with conventional therapies, TTs are delivered over a longer period and often have unusual symptom profiles. Patient reported outcome measures such as symptom side-effect lists need to be developed in a time-efficient manner to enable a rapid and full evaluation of new treatments and effective clinical management

Objective: the aim of this study is to develop a set of TT-related symptoms and identify the optimal method for developing symptom lists.

Patients and Methods: symptoms from TT treatment in the context of Chronic Myeloid Leukaemia (CML), HER2 positive breast cancer, or Gastrointestinal Stromal Tumours (GIST) were identified through literature reviews, interviews with health care professionals (HCPs) and patients, and patient focus groups. The symptom set was then pilot tested in patients across the three cancer diagnoses: The number of items derived from each source (literature, patients, or HCPs) were compared.

Results: a total of 316 patients and 86 HCPs from 16 countries participated. An initial set of 209 symptoms was reduced to 61 covering 12 symptom categories. Patient interviews made the greatest contribution to the item set.

Conclusions: symptom lists should be created based on input from patients. The item set described will be applicable to the assessment of new TTs, and in monitoring treatment.
1776-2596
Sodergren, Samantha
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Wheelwright, Sally
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Fitzsimmons, Deborah
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Efficace, Fabio
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Sprangers, Mirjam
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Fayers, Peter
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Harle, Amelie
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Schmidt, Heike
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Bottomley, Andrew
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Darlington, Anne-Sophie
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Benson, Charlotte
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Bredart, Anne
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Hentschel, Leopold
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Arraras, Juan Ignacio
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Ioannidis, Georgios
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Leahy, Michael
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Lugowska, Iwona
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Nicolatou-Galitis, Ourania
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Petranovic, Duska
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Rohde, Gudrun E
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Vassiliou, Vasilis
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Johnson, Colin D.
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Sodergren, Samantha
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Wheelwright, Sally
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Fitzsimmons, Deborah
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Efficace, Fabio
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Sprangers, Mirjam
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Fayers, Peter
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Harle, Amelie
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Schmidt, Heike
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Bottomley, Andrew
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Darlington, Anne-Sophie
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Benson, Charlotte
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Bredart, Anne
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Hentschel, Leopold
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Arraras, Juan Ignacio
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Ioannidis, Georgios
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Leahy, Michael
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Lugowska, Iwona
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Nicolatou-Galitis, Ourania
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Petranovic, Duska
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Rohde, Gudrun E
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Vassiliou, Vasilis
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Johnson, Colin D.
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Sodergren, Samantha, Wheelwright, Sally, Fitzsimmons, Deborah, Efficace, Fabio, Sprangers, Mirjam, Fayers, Peter, Harle, Amelie, Schmidt, Heike, Bottomley, Andrew, Darlington, Anne-Sophie, Benson, Charlotte, Bredart, Anne, Hentschel, Leopold, Arraras, Juan Ignacio, Ioannidis, Georgios, Leahy, Michael, Lugowska, Iwona, Nicolatou-Galitis, Ourania, Petranovic, Duska, Rohde, Gudrun E, Vassiliou, Vasilis and Johnson, Colin D. (2020) Developing symptom lists for people with cancer treated with targeted therapies. Targeted Oncology. (In Press)

Record type: Article

Abstract

Background: Targeted Therapies (TTs) have revolutionised cancer treatment with their enhanced specificity of action. Compared with conventional therapies, TTs are delivered over a longer period and often have unusual symptom profiles. Patient reported outcome measures such as symptom side-effect lists need to be developed in a time-efficient manner to enable a rapid and full evaluation of new treatments and effective clinical management

Objective: the aim of this study is to develop a set of TT-related symptoms and identify the optimal method for developing symptom lists.

Patients and Methods: symptoms from TT treatment in the context of Chronic Myeloid Leukaemia (CML), HER2 positive breast cancer, or Gastrointestinal Stromal Tumours (GIST) were identified through literature reviews, interviews with health care professionals (HCPs) and patients, and patient focus groups. The symptom set was then pilot tested in patients across the three cancer diagnoses: The number of items derived from each source (literature, patients, or HCPs) were compared.

Results: a total of 316 patients and 86 HCPs from 16 countries participated. An initial set of 209 symptoms was reduced to 61 covering 12 symptom categories. Patient interviews made the greatest contribution to the item set.

Conclusions: symptom lists should be created based on input from patients. The item set described will be applicable to the assessment of new TTs, and in monitoring treatment.

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Developing symptom lists for people with cancer treated with targeted therapies - Accepted Manuscript
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Accepted/In Press date: 7 October 2020

Identifiers

Local EPrints ID: 444724
URI: http://eprints.soton.ac.uk/id/eprint/444724
ISSN: 1776-2596
PURE UUID: dc38e404-d721-4fed-a9be-40b82da41423
ORCID for Samantha Sodergren: ORCID iD orcid.org/0000-0001-8755-146X
ORCID for Sally Wheelwright: ORCID iD orcid.org/0000-0003-0657-2483

Catalogue record

Date deposited: 02 Nov 2020 17:31
Last modified: 07 Oct 2021 04:01

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Contributors

Author: Deborah Fitzsimmons
Author: Fabio Efficace
Author: Mirjam Sprangers
Author: Peter Fayers
Author: Amelie Harle
Author: Heike Schmidt
Author: Andrew Bottomley
Author: Charlotte Benson
Author: Anne Bredart
Author: Leopold Hentschel
Author: Juan Ignacio Arraras
Author: Georgios Ioannidis
Author: Michael Leahy
Author: Iwona Lugowska
Author: Ourania Nicolatou-Galitis
Author: Duska Petranovic
Author: Gudrun E Rohde
Author: Vasilis Vassiliou
Author: Colin D. Johnson

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