SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study
SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study
Objectives: The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults. Methods: Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years. Results: 856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001). Conclusions: The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteristics of viral-associated disease, including illness in a greater proportion of patients without underlying lung disease.
COVID-19, Influenza, Molecular diagnostics, Pneumonia, Point-of-care testing, Respiratory viruses, SARS-CoV-2
966-972
Poole, Stephen
440d7904-ab72-469c-892b-c910cd1cb19b
Brendish, Nathan
a8a4189e-01eb-4ab3-933e-a24cd188a4d7
Clark, Tristan
712ec18e-613c-45df-a013-c8a22834e14f
December 2020
Poole, Stephen
440d7904-ab72-469c-892b-c910cd1cb19b
Brendish, Nathan
a8a4189e-01eb-4ab3-933e-a24cd188a4d7
Clark, Tristan
712ec18e-613c-45df-a013-c8a22834e14f
Poole, Stephen, Brendish, Nathan and Clark, Tristan
(2020)
SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study.
Journal of Infection, 81 (6), .
(doi:10.1016/j.jinf.2020.11.010).
Abstract
Objectives: The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults. Methods: Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years. Results: 856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001). Conclusions: The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteristics of viral-associated disease, including illness in a greater proportion of patients without underlying lung disease.
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Accepted/In Press date: 11 November 2020
e-pub ahead of print date: 15 November 2020
Published date: December 2020
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Funding Information:
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. FluPOC was funded by a NIHR Fellowship awarded to TWC (PDF 2016-09-061) and ResPOC and CoV-19POC were funded by the University of Southampton and University Hospital Southampton NHS Foundation Trust respectively.
Publisher Copyright:
© 2020
Keywords:
COVID-19, Influenza, Molecular diagnostics, Pneumonia, Point-of-care testing, Respiratory viruses, SARS-CoV-2
Identifiers
Local EPrints ID: 445117
URI: http://eprints.soton.ac.uk/id/eprint/445117
ISSN: 0163-4453
PURE UUID: e095731d-170c-4c7f-b774-f49776c13914
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Date deposited: 19 Nov 2020 17:33
Last modified: 14 Dec 2024 05:03
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Author:
Stephen Poole
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