The University of Southampton
University of Southampton Institutional Repository

SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study

SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study
SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study

Objectives: The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults. Methods: Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years. Results: 856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001). Conclusions: The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteristics of viral-associated disease, including illness in a greater proportion of patients without underlying lung disease.

COVID-19, Influenza, Molecular diagnostics, Pneumonia, Point-of-care testing, Respiratory viruses, SARS-CoV-2
0163-4453
966-972
Poole, Stephen
440d7904-ab72-469c-892b-c910cd1cb19b
Brendish, Nathan
a8a4189e-01eb-4ab3-933e-a24cd188a4d7
Clark, Tristan
712ec18e-613c-45df-a013-c8a22834e14f
Poole, Stephen
440d7904-ab72-469c-892b-c910cd1cb19b
Brendish, Nathan
a8a4189e-01eb-4ab3-933e-a24cd188a4d7
Clark, Tristan
712ec18e-613c-45df-a013-c8a22834e14f

Poole, Stephen, Brendish, Nathan and Clark, Tristan (2020) SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study. Journal of Infection, 81 (6), 966-972. (doi:10.1016/j.jinf.2020.11.010).

Record type: Article

Abstract

Objectives: The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults. Methods: Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years. Results: 856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001). Conclusions: The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteristics of viral-associated disease, including illness in a greater proportion of patients without underlying lung disease.

Text
Main v8 - Accepted Manuscript
Download (98kB)

More information

Accepted/In Press date: 11 November 2020
e-pub ahead of print date: 15 November 2020
Published date: December 2020
Additional Information: Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. FluPOC was funded by a NIHR Fellowship awarded to TWC (PDF 2016-09-061) and ResPOC and CoV-19POC were funded by the University of Southampton and University Hospital Southampton NHS Foundation Trust respectively. Publisher Copyright: © 2020
Keywords: COVID-19, Influenza, Molecular diagnostics, Pneumonia, Point-of-care testing, Respiratory viruses, SARS-CoV-2

Identifiers

Local EPrints ID: 445117
URI: http://eprints.soton.ac.uk/id/eprint/445117
ISSN: 0163-4453
PURE UUID: e095731d-170c-4c7f-b774-f49776c13914
ORCID for Nathan Brendish: ORCID iD orcid.org/0000-0002-9589-4937
ORCID for Tristan Clark: ORCID iD orcid.org/0000-0001-6026-5295

Catalogue record

Date deposited: 19 Nov 2020 17:33
Last modified: 19 Mar 2024 05:03

Export record

Altmetrics

Contributors

Author: Stephen Poole
Author: Nathan Brendish ORCID iD
Author: Tristan Clark ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×