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SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study

SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study
SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study
Objectives The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults.
Methods Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years.
Results 856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001).
Conclusions The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteristics of viral-associated disease, including illness in a greater proportion of patients without underlying lung disease.
COVID-19, Influenza, Molecular diagnostics, Pneumonia, Point-of-care testing, Respiratory viruses, SARS-CoV-2
0163-4453
966-972
Poole, Stephen
440d7904-ab72-469c-892b-c910cd1cb19b
Brendish, Nathan
a8a4189e-01eb-4ab3-933e-a24cd188a4d7
Clark, Tristan
712ec18e-613c-45df-a013-c8a22834e14f
Poole, Stephen
440d7904-ab72-469c-892b-c910cd1cb19b
Brendish, Nathan
a8a4189e-01eb-4ab3-933e-a24cd188a4d7
Clark, Tristan
712ec18e-613c-45df-a013-c8a22834e14f

Poole, Stephen, Brendish, Nathan and Clark, Tristan (2020) SARS-CoV-2 has displaced other seasonal respiratory viruses: results from a prospective cohort study. Journal of Infection, 81 (6), 966-972. (doi:10.1016/j.jinf.2020.11.010).

Record type: Article

Abstract

Objectives The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults.
Methods Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years.
Results 856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001).
Conclusions The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteristics of viral-associated disease, including illness in a greater proportion of patients without underlying lung disease.

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Main v8 - Accepted Manuscript
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More information

Accepted/In Press date: 11 November 2020
e-pub ahead of print date: 15 November 2020
Keywords: COVID-19, Influenza, Molecular diagnostics, Pneumonia, Point-of-care testing, Respiratory viruses, SARS-CoV-2

Identifiers

Local EPrints ID: 445117
URI: http://eprints.soton.ac.uk/id/eprint/445117
ISSN: 0163-4453
PURE UUID: e095731d-170c-4c7f-b774-f49776c13914
ORCID for Nathan Brendish: ORCID iD orcid.org/0000-0002-9589-4937
ORCID for Tristan Clark: ORCID iD orcid.org/0000-0001-6026-5295

Catalogue record

Date deposited: 19 Nov 2020 17:33
Last modified: 07 Oct 2021 02:01

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