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Evaluating ceftriaxone 80 mg/kg administration by rapid intravenous infusion-A clinical service evaluation

Evaluating ceftriaxone 80 mg/kg administration by rapid intravenous infusion-A clinical service evaluation
Evaluating ceftriaxone 80 mg/kg administration by rapid intravenous infusion-A clinical service evaluation

In pediatric ambulatory care, the speed of medication infusion can have major impact on healthcare staff workload and the number of children able to be treated by services designed to reduce inpatient length of stay. In many regions of the world, local and supraregional guidelines allow ceftriaxone infusions of ≥50 mg/kg in infants and children up to 12 years of age to be given over 10 minutes. The generic European summary of product characteristics for ceftriaxone does not state a specific infusion time for this dose range, although 1 manufacturers' summary of product characteristics in the United Kingdom states a 30-minute minimum infusion time. We conducted a formal service evaluation of a change in practice at a large UK pediatric children's hospital and demonstrated the clinical feasibility, safety, and high parent satisfaction of 10-minute ceftriaxone infusions for prescribed doses ≥50 mg/kg. This approach can improve patient flow within hospital-based ambulatory services as well as by community nursing teams administering antibiotics at home.

0891-3668
1-2
Patel, Sanjay
bc976df6-0414-459f-8390-3eca85e07d97
Green, Helen
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Gray, Jacqueline
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Rutter, Michelle
fb45db93-cd5b-4335-b9bc-821dbba5325d
Bevan, Amanda
22780ba6-52a9-417f-b469-f36f64b9c8fc
Hand, Kieran
5407b07a-7b4b-47e2-b0cf-d662f7d7a3e6
Jones, Christine E
48229079-8b58-4dcb-8374-d9481fe7b426
Faust, Saul N
f97df780-9f9b-418e-b349-7adf63e150c1
Patel, Sanjay
bc976df6-0414-459f-8390-3eca85e07d97
Green, Helen
9a446138-c1b3-4548-969a-19c96e98905f
Gray, Jacqueline
2f0f242d-eab9-43ec-9634-a05ab85fb208
Rutter, Michelle
fb45db93-cd5b-4335-b9bc-821dbba5325d
Bevan, Amanda
22780ba6-52a9-417f-b469-f36f64b9c8fc
Hand, Kieran
5407b07a-7b4b-47e2-b0cf-d662f7d7a3e6
Jones, Christine E
48229079-8b58-4dcb-8374-d9481fe7b426
Faust, Saul N
f97df780-9f9b-418e-b349-7adf63e150c1

Patel, Sanjay, Green, Helen, Gray, Jacqueline, Rutter, Michelle, Bevan, Amanda, Hand, Kieran, Jones, Christine E and Faust, Saul N (2020) Evaluating ceftriaxone 80 mg/kg administration by rapid intravenous infusion-A clinical service evaluation. The Pediatric infectious disease journal, 1-2. (doi:10.1097/INF.0000000000002923).

Record type: Article

Abstract

In pediatric ambulatory care, the speed of medication infusion can have major impact on healthcare staff workload and the number of children able to be treated by services designed to reduce inpatient length of stay. In many regions of the world, local and supraregional guidelines allow ceftriaxone infusions of ≥50 mg/kg in infants and children up to 12 years of age to be given over 10 minutes. The generic European summary of product characteristics for ceftriaxone does not state a specific infusion time for this dose range, although 1 manufacturers' summary of product characteristics in the United Kingdom states a 30-minute minimum infusion time. We conducted a formal service evaluation of a change in practice at a large UK pediatric children's hospital and demonstrated the clinical feasibility, safety, and high parent satisfaction of 10-minute ceftriaxone infusions for prescribed doses ≥50 mg/kg. This approach can improve patient flow within hospital-based ambulatory services as well as by community nursing teams administering antibiotics at home.

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Evaluating the safety of ceftriaxone manuscript_rev - Accepted Manuscript
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Accepted/In Press date: 9 August 2020
e-pub ahead of print date: 26 October 2020

Identifiers

Local EPrints ID: 445260
URI: http://eprints.soton.ac.uk/id/eprint/445260
ISSN: 0891-3668
PURE UUID: 8c54418a-3309-4736-a726-11bf4757978c
ORCID for Kieran Hand: ORCID iD orcid.org/0000-0002-3834-2415
ORCID for Christine E Jones: ORCID iD orcid.org/0000-0003-1523-2368
ORCID for Saul N Faust: ORCID iD orcid.org/0000-0003-3410-7642

Catalogue record

Date deposited: 26 Nov 2020 17:32
Last modified: 26 Nov 2021 06:17

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Contributors

Author: Sanjay Patel
Author: Helen Green
Author: Jacqueline Gray
Author: Michelle Rutter
Author: Amanda Bevan
Author: Kieran Hand ORCID iD
Author: Saul N Faust ORCID iD

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