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Cohort Profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)

Cohort Profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)
Cohort Profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)
The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring. Between February 2015 and October 2017, the S-PRESTO study recruited 1039 Chinese, Malay or Indian (or any combinations thereof) women aged 18–45 years and who intended to get pregnant and deliver in Singapore, resulting in 1032 unique participants and 373 children born in the cohort. The participants were followed up for 3 visits during the preconception phase and censored at 12 months of follow up if pregnancy was not achieved (N = 557 censored). Women who successfully conceived (N = 475) were characterised at gestational weeks 6–8, 11–13, 18–21, 24–26, 27–28 and 34–36. Follow up of their index offspring (N = 373 singletons) is on-going at birth, 1, 3 and 6 weeks, 3, 6, 12, 18, 24 and 36 months and beyond. Women are also being followed up post-delivery. Data is collected via interviewer-administered questionnaires, metabolic imaging (magnetic resonance imaging), standardized anthropometric measurements and collection of diverse specimens, i.e. blood, urine, buccal smear, stool, skin tapes, epithelial swabs at numerous timepoints. S-PRESTO has extensive repeated data collected which include genetic and epigenetic sampling from preconception which is unique in mother–offspring epidemiological cohorts. This enables prospective assessment of a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood. In addition, the S-PRESTO study draws from the three major Asian ethnic groups that represent 50% of the global population, increasing the relevance of its findings to global efforts to address non-communicable diseases.
0393-2990
Loo, Evelyn X.L.
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Soh, S.E.
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Loy, See
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Ng, Sharon
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Tint, M.T.
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Chan, Shiao-Yng
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Huang, Jonathan Y.
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Yap, Fabian
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Tan, K.H.
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Chern, Bernard S.M.
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Tan, H.H.
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Karnani, Neerja
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Gluckman, Peter D.
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Shek, Lynette P.
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Eriksson, Johan G.
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S-PRESTO Study Group
Loo, Evelyn X.L.
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Soh, S.E.
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Loy, See
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Ng, Sharon
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Tint, M.T.
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Chan, Shiao-Yng
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Huang, Jonathan Y.
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Yap, Fabian
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Tan, K.H.
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Chern, Bernard S.M.
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Tan, H.H.
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Meaney, Michael
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Karnani, Neerja
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Godfrey, Keith
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Lee, Yung Seng
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Chan, Jerry Kok Yen
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Gluckman, Peter D.
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Chong, Y-S
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Shek, Lynette P.
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Eriksson, Johan G.
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S-PRESTO Study Group (2020) Cohort Profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO). European Journal of Epidemiology. (doi:10.1007/s10654-020-00697-2).

Record type: Article

Abstract

The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring. Between February 2015 and October 2017, the S-PRESTO study recruited 1039 Chinese, Malay or Indian (or any combinations thereof) women aged 18–45 years and who intended to get pregnant and deliver in Singapore, resulting in 1032 unique participants and 373 children born in the cohort. The participants were followed up for 3 visits during the preconception phase and censored at 12 months of follow up if pregnancy was not achieved (N = 557 censored). Women who successfully conceived (N = 475) were characterised at gestational weeks 6–8, 11–13, 18–21, 24–26, 27–28 and 34–36. Follow up of their index offspring (N = 373 singletons) is on-going at birth, 1, 3 and 6 weeks, 3, 6, 12, 18, 24 and 36 months and beyond. Women are also being followed up post-delivery. Data is collected via interviewer-administered questionnaires, metabolic imaging (magnetic resonance imaging), standardized anthropometric measurements and collection of diverse specimens, i.e. blood, urine, buccal smear, stool, skin tapes, epithelial swabs at numerous timepoints. S-PRESTO has extensive repeated data collected which include genetic and epigenetic sampling from preconception which is unique in mother–offspring epidemiological cohorts. This enables prospective assessment of a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood. In addition, the S-PRESTO study draws from the three major Asian ethnic groups that represent 50% of the global population, increasing the relevance of its findings to global efforts to address non-communicable diseases.

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SPRESTO paper EJE final clean EL 260320 - Accepted Manuscript
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Accepted/In Press date: 4 November 2020
e-pub ahead of print date: 21 November 2020

Identifiers

Local EPrints ID: 445276
URI: http://eprints.soton.ac.uk/id/eprint/445276
ISSN: 0393-2990
PURE UUID: 2b96a114-a1bb-445d-ab12-32152de69fec
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 30 Nov 2020 17:31
Last modified: 26 Nov 2021 06:36

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Contributors

Author: Evelyn X.L. Loo
Author: S.E. Soh
Author: See Loy
Author: Sharon Ng
Author: M.T. Tint
Author: Shiao-Yng Chan
Author: Jonathan Y. Huang
Author: Fabian Yap
Author: K.H. Tan
Author: Bernard S.M. Chern
Author: H.H. Tan
Author: Michael Meaney
Author: Neerja Karnani
Author: Keith Godfrey ORCID iD
Author: Yung Seng Lee
Author: Jerry Kok Yen Chan
Author: Peter D. Gluckman
Author: Y-S Chong
Author: Lynette P. Shek
Author: Johan G. Eriksson
Corporate Author: S-PRESTO Study Group

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