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Natural products in drug discovery: advances and opportunities

Natural products in drug discovery: advances and opportunities
Natural products in drug discovery: advances and opportunities
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers for screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
1474-1776
200–216
Atanasov, Atanas G.
92867038-102f-4422-ba15-3035f36a94f9
Supuran, Claudiu T.
66fd18ca-00c1-4f47-9bad-4752b4abe202
Zotchev, Sergey B.
9d2db201-8ab5-4a6d-ab57-efc4b3febf94
Dirsch, Verena M.
e326e4b8-fec6-49b8-b810-79972a807358
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
International Natural Product Sciences Taskforce
Atanasov, Atanas G.
92867038-102f-4422-ba15-3035f36a94f9
Supuran, Claudiu T.
66fd18ca-00c1-4f47-9bad-4752b4abe202
Zotchev, Sergey B.
9d2db201-8ab5-4a6d-ab57-efc4b3febf94
Dirsch, Verena M.
e326e4b8-fec6-49b8-b810-79972a807358
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd

International Natural Product Sciences Taskforce (2021) Natural products in drug discovery: advances and opportunities. Nature Reviews. Drug Discovery, 20, 200–216.

Record type: Article

Abstract

Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers for screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.

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More information

Accepted/In Press date: 9 December 2020
e-pub ahead of print date: 28 January 2021

Identifiers

Local EPrints ID: 445759
URI: http://eprints.soton.ac.uk/id/eprint/445759
ISSN: 1474-1776
PURE UUID: 04d47fed-2da7-467c-80da-0a3160c8085d
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 07 Jan 2021 17:32
Last modified: 24 Sep 2021 04:01

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Contributors

Author: Atanas G. Atanasov
Author: Claudiu T. Supuran
Author: Sergey B. Zotchev
Author: Verena M. Dirsch
Author: Keith Godfrey ORCID iD
Corporate Author: International Natural Product Sciences Taskforce

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