The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The influence of anxiety symptoms on clinical outcomes during baclofen treatment of alcohol use disorder: A systematic review and meta-analysis

The influence of anxiety symptoms on clinical outcomes during baclofen treatment of alcohol use disorder: A systematic review and meta-analysis
The influence of anxiety symptoms on clinical outcomes during baclofen treatment of alcohol use disorder: A systematic review and meta-analysis

Given the high coexistence of anxiety symptoms in people with alcohol use disorder (AUD), we aimed to determine the influence of anxiety symptoms on outcomes in patients with AUD treated with the GABA B receptor agonist baclofen. A meta-analysis of 13 comparisons (published 2010–2020) including baseline and outcome data on alcohol consumption and anxiety after 12 weeks was undertaken. There were significantly higher rates of abstinent days in patients treated with baclofen compared to placebo (p = 0.004; high certainty evidence); specifically in those with higher baseline anxiety levels (p < 0.00001; high certainty evidence) compared to those with lower baseline anxiety levels (p = 0.20; moderate certainty evidence). The change in anxiety ratings over 12 weeks did not differ between those treated with baclofen or placebo (p = 0.84; moderate certainty evidence). This may be due to different anxiety constructs being measured by scales not validated in this patient group, or that anxiety is not a biobehavioral mechanism by which baclofen may reduce alcohol drinking. Given the prevalence of anxiety symptoms in AUD all these factors warrant further research.

Alcohol, Anxiety, Baclofen, Clinical trials, GABA, Measurement, Meta-analysis, Rating scales
0149-7634
296-313
Agabio, Roberta
fad70532-c2fd-49ac-8d05-5a6a9b0fa7c0
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Amaro, Hugo
1151d701-7c46-4481-92d8-3fbd14e67610
Leggio, Lorenzo
f4c540a5-75e0-47b0-bbbd-457aa9977f74
Sinclair, Julia
be3e54d5-c6da-4950-b0ba-3cb8cdcab13c
Agabio, Roberta
fad70532-c2fd-49ac-8d05-5a6a9b0fa7c0
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Amaro, Hugo
1151d701-7c46-4481-92d8-3fbd14e67610
Leggio, Lorenzo
f4c540a5-75e0-47b0-bbbd-457aa9977f74
Sinclair, Julia
be3e54d5-c6da-4950-b0ba-3cb8cdcab13c

Agabio, Roberta, Baldwin, David, Amaro, Hugo, Leggio, Lorenzo and Sinclair, Julia (2021) The influence of anxiety symptoms on clinical outcomes during baclofen treatment of alcohol use disorder: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 125, 296-313. (doi:10.1016/j.neubiorev.2020.12.030).

Record type: Article

Abstract

Given the high coexistence of anxiety symptoms in people with alcohol use disorder (AUD), we aimed to determine the influence of anxiety symptoms on outcomes in patients with AUD treated with the GABA B receptor agonist baclofen. A meta-analysis of 13 comparisons (published 2010–2020) including baseline and outcome data on alcohol consumption and anxiety after 12 weeks was undertaken. There were significantly higher rates of abstinent days in patients treated with baclofen compared to placebo (p = 0.004; high certainty evidence); specifically in those with higher baseline anxiety levels (p < 0.00001; high certainty evidence) compared to those with lower baseline anxiety levels (p = 0.20; moderate certainty evidence). The change in anxiety ratings over 12 weeks did not differ between those treated with baclofen or placebo (p = 0.84; moderate certainty evidence). This may be due to different anxiety constructs being measured by scales not validated in this patient group, or that anxiety is not a biobehavioral mechanism by which baclofen may reduce alcohol drinking. Given the prevalence of anxiety symptoms in AUD all these factors warrant further research.

Text
Balcofen metanalysis-accepted 27.12.20 - Accepted Manuscript
Restricted to Repository staff only until 14 January 2022.
Request a copy

More information

Accepted/In Press date: 27 December 2020
e-pub ahead of print date: 14 January 2021
Published date: June 2021
Keywords: Alcohol, Anxiety, Baclofen, Clinical trials, GABA, Measurement, Meta-analysis, Rating scales

Identifiers

Local EPrints ID: 446276
URI: http://eprints.soton.ac.uk/id/eprint/446276
ISSN: 0149-7634
PURE UUID: 1f0d55da-6ae3-417f-b6a3-dc7ec9c711c7
ORCID for David Baldwin: ORCID iD orcid.org/0000-0003-3343-0907
ORCID for Julia Sinclair: ORCID iD orcid.org/0000-0002-1905-2025

Catalogue record

Date deposited: 03 Feb 2021 17:34
Last modified: 18 Aug 2021 01:35

Export record

Altmetrics

Contributors

Author: Roberta Agabio
Author: David Baldwin ORCID iD
Author: Hugo Amaro
Author: Lorenzo Leggio
Author: Julia Sinclair ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×