Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and beta-CTX in blood
Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and beta-CTX in blood
Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.
Bone formation, Bone resorption, Bone turnover markers, C-terminal telopeptide of type I collagen, Harmonization, PINP, Procollagen type I N-propeptide, Standardization, β-CTX
16-20
Bhattoa, Harjit P.
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Cavalier, Etienne
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Eastell, Richard
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Heijboer, Annemieke C.
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Rye Jørgensen, Niklas
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Makris, Konstantinos
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Ulmer, Candice Z.
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Kanis, John A.
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Cooper, Cyrus
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Silverman, Stuart L.
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Vasikaran, Samuel D.
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IFCC-IOF Committee for Bone Metabolism.
April 2021
Bhattoa, Harjit P.
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Cavalier, Etienne
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Eastell, Richard
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Heijboer, Annemieke C.
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Rye Jørgensen, Niklas
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Makris, Konstantinos
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Ulmer, Candice Z.
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Kanis, John A.
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Cooper, Cyrus
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Silverman, Stuart L.
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Vasikaran, Samuel D.
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Bhattoa, Harjit P., Cavalier, Etienne, Eastell, Richard, Heijboer, Annemieke C., Rye Jørgensen, Niklas, Makris, Konstantinos, Ulmer, Candice Z., Kanis, John A., Cooper, Cyrus, Silverman, Stuart L. and Vasikaran, Samuel D.
,
IFCC-IOF Committee for Bone Metabolism.
(2021)
Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and beta-CTX in blood.
Clinica Chimica Acta, 515, .
(doi:10.1016/j.cca.2020.12.023).
Abstract
Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.
Text
C-BM paper on bone markers for CCA 2020 Revised 2_12_20
- Accepted Manuscript
More information
Accepted/In Press date: 18 December 2020
e-pub ahead of print date: 28 December 2020
Published date: April 2021
Additional Information:
Funding Information:
EC is a consultant for Diasorin, IDS, Fujirebio, bioMerieux, Menarini and Nittobo. RE receives consultancy funding from IDS, Roche Diagnostics, GSK Nutrition, FNIH, Mereo, Lilly, Sandoz, Nittobo, Abbvie, Samsung, Haoma Medica, CL Bio, and Viking and grant funding from Nittobo, IDS, Roche, Amgen and Alexion. NRJ has received free reagents for research use from Roche Diagnostics and IDS. JAK reports grant support from Amgen, Lilly and Radius Health. CC has received lecture fees and honoraria from Amgen, Danone, Eli Lilly, GSK, Kyowa Kirin, Medtronic, Merck, Nestlé, Novartis, Pfizer, Roche, Servier, Shire, Takeda and UCB outside of the submitted work. SLS has received grant support from Roche, consulting funding from Amgen, Pfizer, Lilly, Radius and is a speaker for Amgen and Radius.
Publisher Copyright:
© 2020 Elsevier B.V.
Keywords:
Bone formation, Bone resorption, Bone turnover markers, C-terminal telopeptide of type I collagen, Harmonization, PINP, Procollagen type I N-propeptide, Standardization, β-CTX
Identifiers
Local EPrints ID: 446302
URI: http://eprints.soton.ac.uk/id/eprint/446302
ISSN: 0009-8981
PURE UUID: b8361fb0-03af-4230-8726-9689efa3fb52
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Date deposited: 04 Feb 2021 17:30
Last modified: 18 Mar 2024 05:08
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Contributors
Author:
Harjit P. Bhattoa
Author:
Etienne Cavalier
Author:
Richard Eastell
Author:
Annemieke C. Heijboer
Author:
Niklas Rye Jørgensen
Author:
Konstantinos Makris
Author:
Candice Z. Ulmer
Author:
John A. Kanis
Author:
Stuart L. Silverman
Author:
Samuel D. Vasikaran
Corporate Author: IFCC-IOF Committee for Bone Metabolism.
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