The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood

Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood
Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood
Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.
Bone formation, Bone resorption, Bone turnover markers, C-terminal telopeptide of type I collagen, Harmonization, PINP, Procollagen type I N-propeptide, Standardization, β-CTX
0009-8981
16-20
Bhattoa, Harjit P.
a67d970a-86c6-4bce-bac4-ec8c032c53e4
Cavalier, Etienne
bc312308-1b70-4434-ab15-28860479d2e9
Eastell, Richard
b19615e4-bc97-4ddf-b8d7-7f48b7220228
Heijboer, Annemieke C.
dc2a8ad8-7677-4e92-9cdb-73f95e567ead
Rye Jørgensen, Niklas
1f275e88-62c2-489a-a323-1f31900f548d
Makris, Konstantinos
1d7847d4-7ace-417c-8c5b-c0f892558d47
Ulmer, Candice Z.
b0f6baff-e0f1-45ad-902a-7900d2a4e34d
Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Silverman, Stuart L.
f66e4023-8708-449e-b623-dcb63835912e
Vasikaran, Samuel D.
8b2886f5-545c-4734-949e-26ee91b88176
IFCC-IOF Committee for Bone Metabolism.
Bhattoa, Harjit P.
a67d970a-86c6-4bce-bac4-ec8c032c53e4
Cavalier, Etienne
bc312308-1b70-4434-ab15-28860479d2e9
Eastell, Richard
b19615e4-bc97-4ddf-b8d7-7f48b7220228
Heijboer, Annemieke C.
dc2a8ad8-7677-4e92-9cdb-73f95e567ead
Rye Jørgensen, Niklas
1f275e88-62c2-489a-a323-1f31900f548d
Makris, Konstantinos
1d7847d4-7ace-417c-8c5b-c0f892558d47
Ulmer, Candice Z.
b0f6baff-e0f1-45ad-902a-7900d2a4e34d
Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Silverman, Stuart L.
f66e4023-8708-449e-b623-dcb63835912e
Vasikaran, Samuel D.
8b2886f5-545c-4734-949e-26ee91b88176

Bhattoa, Harjit P., Cavalier, Etienne, Eastell, Richard, Heijboer, Annemieke C., Rye Jørgensen, Niklas, Makris, Konstantinos, Ulmer, Candice Z., Kanis, John A., Cooper, Cyrus, Silverman, Stuart L. and Vasikaran, Samuel D. , IFCC-IOF Committee for Bone Metabolism. (2021) Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood. Clinica Chimica Acta, 515, 16-20. (doi:10.1016/j.cca.2020.12.023).

Record type: Article

Abstract

Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.

Text
C-BM paper on bone markers for CCA 2020 Revised 2_12_20 - Accepted Manuscript
Restricted to Repository staff only until 28 December 2021.
Request a copy

More information

Accepted/In Press date: 18 December 2020
e-pub ahead of print date: 28 December 2020
Published date: April 2021
Keywords: Bone formation, Bone resorption, Bone turnover markers, C-terminal telopeptide of type I collagen, Harmonization, PINP, Procollagen type I N-propeptide, Standardization, β-CTX

Identifiers

Local EPrints ID: 446302
URI: http://eprints.soton.ac.uk/id/eprint/446302
ISSN: 0009-8981
PURE UUID: b8361fb0-03af-4230-8726-9689efa3fb52
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 04 Feb 2021 17:30
Last modified: 22 Nov 2021 02:41

Export record

Altmetrics

Contributors

Author: Harjit P. Bhattoa
Author: Etienne Cavalier
Author: Richard Eastell
Author: Annemieke C. Heijboer
Author: Niklas Rye Jørgensen
Author: Konstantinos Makris
Author: Candice Z. Ulmer
Author: John A. Kanis
Author: Cyrus Cooper ORCID iD
Author: Stuart L. Silverman
Author: Samuel D. Vasikaran
Corporate Author: IFCC-IOF Committee for Bone Metabolism.

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×