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The impact of diet during adolescence on the neonatal health of offspring: evidence on the importance of preconception diet. The HUNT study

The impact of diet during adolescence on the neonatal health of offspring: evidence on the importance of preconception diet. The HUNT study
The impact of diet during adolescence on the neonatal health of offspring: evidence on the importance of preconception diet. The HUNT study
Emerging evidence suggests that parents’ nutritional status before and at the time of conception influences the lifelong physical and mental health of their child. Yet little is known about the relationship between diet in adolescence and the health of the next generation at birth. This study examined data from Norwegian cohorts to assess the relationship between dietary patterns in adolescence and neonatal outcomes. Data from adolescents who participated in the Nord-Trøndelag Health Study (Young-HUNT) were merged with birth data for their offspring through the Medical Birth Registry of Norway. Young-HUNT1 collected data from 8980 adolescents between 1995 and 1997. Linear regression was used to assess associations between adolescents’ diet and later neonatal outcomes of their offspring adjusting for sociodemographic factors. Analyses were replicated with data from the Young-HUNT3 cohort (dietary data collected from 2006 to 2008) and combined with Young-HUNT1 for pooled analyses. In Young-HUNT1, there was evidence of associations between dietary choices, meal patterns, and neonatal outcomes, these were similar in the pooled analyses but were attenuated to the point of nonsignificance in the smaller Young-HUNT3 cohort. Overall, energy-dense food products were associated with a small detrimental impact on some neonatal outcomes, whereas healthier food choices appeared protective. Our study suggests that there are causal links between consumption of healthy and unhealthy food and meal patterns in adolescence with neonatal outcomes for offspring some years later. The effects seen are small and will require even larger studies with more state-of-the-art dietary assessment to estimate these robustly.
2040-1744
Van Lippevelde, Wendy
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Vik, Froydis N
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Wills, Andrew K.
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Strommer, Sofia
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Barker, Mary
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Skreden, Marianne
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Anderson Berry, Ann
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Hanson, Corinne
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Brantsæter, Anne Lise
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Hillesund, Elisabeth R
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Øverby, Nina C
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Van Lippevelde, Wendy
60006a51-a06a-4a8c-a2b6-4a365271883e
Vik, Froydis N
ce7ca8e8-09e2-4a3e-bae5-8dc4e2708676
Wills, Andrew K.
46f423e1-510f-49e2-9a26-5e846d84f3fd
Strommer, Sofia
a025047e-effa-4481-9bf4-48da1668649e
Barker, Mary
374310ad-d308-44af-b6da-515bf5d2d6d2
Skreden, Marianne
e42f700e-6180-4b62-b781-3daa2d908cea
Anderson Berry, Ann
13001ec3-3984-4544-9006-19065aa67190
Hanson, Corinne
c5580e2e-4652-414c-8700-84511b72d12d
Brantsæter, Anne Lise
3959b39a-f476-4fa0-adc7-b87591155e7f
Hillesund, Elisabeth R
e8ab2f50-bf30-4630-a08a-61a6118d4a30
Øverby, Nina C
5dc65135-16f4-4e2b-b4d9-6168d3543dd2

Van Lippevelde, Wendy, Vik, Froydis N, Wills, Andrew K., Strommer, Sofia, Barker, Mary, Skreden, Marianne, Anderson Berry, Ann, Hanson, Corinne, Brantsæter, Anne Lise, Hillesund, Elisabeth R and Øverby, Nina C (2020) The impact of diet during adolescence on the neonatal health of offspring: evidence on the importance of preconception diet. The HUNT study. Journal of Developmental Origins of Health and Disease. (doi:10.1017/S2040174420001087).

Record type: Article

Abstract

Emerging evidence suggests that parents’ nutritional status before and at the time of conception influences the lifelong physical and mental health of their child. Yet little is known about the relationship between diet in adolescence and the health of the next generation at birth. This study examined data from Norwegian cohorts to assess the relationship between dietary patterns in adolescence and neonatal outcomes. Data from adolescents who participated in the Nord-Trøndelag Health Study (Young-HUNT) were merged with birth data for their offspring through the Medical Birth Registry of Norway. Young-HUNT1 collected data from 8980 adolescents between 1995 and 1997. Linear regression was used to assess associations between adolescents’ diet and later neonatal outcomes of their offspring adjusting for sociodemographic factors. Analyses were replicated with data from the Young-HUNT3 cohort (dietary data collected from 2006 to 2008) and combined with Young-HUNT1 for pooled analyses. In Young-HUNT1, there was evidence of associations between dietary choices, meal patterns, and neonatal outcomes, these were similar in the pooled analyses but were attenuated to the point of nonsignificance in the smaller Young-HUNT3 cohort. Overall, energy-dense food products were associated with a small detrimental impact on some neonatal outcomes, whereas healthier food choices appeared protective. Our study suggests that there are causal links between consumption of healthy and unhealthy food and meal patterns in adolescence with neonatal outcomes for offspring some years later. The effects seen are small and will require even larger studies with more state-of-the-art dietary assessment to estimate these robustly.

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Van Lippevelde_ManuscriptJDOHaD_revision v1 - Accepted Manuscript
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Accepted/In Press date: 16 October 2020
e-pub ahead of print date: 1 December 2020

Identifiers

Local EPrints ID: 446364
URI: http://eprints.soton.ac.uk/id/eprint/446364
ISSN: 2040-1744
PURE UUID: ebaed98a-5df7-48c3-9b43-b40100296ef5
ORCID for Mary Barker: ORCID iD orcid.org/0000-0003-2976-0217

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Date deposited: 05 Feb 2021 17:31
Last modified: 01 Jun 2021 04:01

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Contributors

Author: Wendy Van Lippevelde
Author: Froydis N Vik
Author: Andrew K. Wills
Author: Sofia Strommer
Author: Mary Barker ORCID iD
Author: Marianne Skreden
Author: Ann Anderson Berry
Author: Corinne Hanson
Author: Anne Lise Brantsæter
Author: Elisabeth R Hillesund
Author: Nina C Øverby

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