The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

The effect on subsequent fracture risk of age, sex and prior fracture site by recency of prior fracture

The effect on subsequent fracture risk of age, sex and prior fracture site by recency of prior fracture
The effect on subsequent fracture risk of age, sex and prior fracture site by recency of prior fracture
Summary
The risk of a recurrent fragility fracture varies by age and sex, as by site and recency of sentinel fracture.

Introduction
The recency of prior fractures affects subsequent fracture risk. Variable recency may obscure other factors that affect subsequent fracture risk. The aim of this study was to quantify the effect of a sentinel fracture by site, age, and sex where the recency was held constant.

Methods
The study used data from the Reykjavik Study fracture register that documented prospectively all fractures at all skeletal sites in a large sample of the population of Iceland. Fracture incidence was compared to that of the general population determined at fixed times after a sentinel fracture (humeral, clinical vertebral, forearm, hip, and minor fractures). Outcome fractures comprised a major osteoporotic fracture and hip fracture.

Results
Sentinel osteoporotic fractures were identified in 9504 men and women. Of these, 3616 individuals sustained a major osteoporotic fracture as the first subsequent fracture, of whom 1799 sustained a hip fracture. Hazard ratios for prior fracture were consistently higher in men than in women and decreased progressively with age. Hazard ratios varied according to the site of sentinel fracture with higher ratios for hip and vertebral fracture than for humerus, forearm, or minor osteoporotic fracture.

Conclusion
The risk of a recurrent fragility fracture varies by age, sex, and site of sentinel fracture when recency is held constant.
Fracture risk, Prior fracture, Recency of fracture, Risk assessment, Sentinel fracture
0937-941X
1547-1555
Kanis, J.A,
52c2c5a7-a17a-49dd-9b2a-30b5a1750a5d
Johansson, H.
05aa5476-bcb9-4b97-905e-00f1dfd9d691
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Gudnason, V.
75cefe2e-c5f6-4d85-9a92-cd8c29dd6a94
Sigurdsson, G.
53162212-0166-486a-8e94-4647c645d882
Siggeirsdottir, K.
bc469433-457c-420a-99c5-ef774c9ae4af
Lorentzon, M.
9d78ed25-2b0c-46c5-a2db-a8b246af0956
Liu, E.
08027c15-9e71-44bb-9623-3081f5f6492d
Vandenput, L.
0910d143-4b58-4579-82b0-3810272f1814
McCloskey, E.V.
2f057a16-3d4e-4597-80c7-6ce47f969c78
Kanis, J.A,
52c2c5a7-a17a-49dd-9b2a-30b5a1750a5d
Johansson, H.
05aa5476-bcb9-4b97-905e-00f1dfd9d691
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Gudnason, V.
75cefe2e-c5f6-4d85-9a92-cd8c29dd6a94
Sigurdsson, G.
53162212-0166-486a-8e94-4647c645d882
Siggeirsdottir, K.
bc469433-457c-420a-99c5-ef774c9ae4af
Lorentzon, M.
9d78ed25-2b0c-46c5-a2db-a8b246af0956
Liu, E.
08027c15-9e71-44bb-9623-3081f5f6492d
Vandenput, L.
0910d143-4b58-4579-82b0-3810272f1814
McCloskey, E.V.
2f057a16-3d4e-4597-80c7-6ce47f969c78

Kanis, J.A,, Johansson, H., Harvey, N.C., Gudnason, V., Sigurdsson, G., Siggeirsdottir, K., Lorentzon, M., Liu, E., Vandenput, L. and McCloskey, E.V. (2021) The effect on subsequent fracture risk of age, sex and prior fracture site by recency of prior fracture. Osteoporosis International, 32 (8), 1547-1555. (doi:10.1007/s00198-020-05803-4).

Record type: Article

Abstract

Summary
The risk of a recurrent fragility fracture varies by age and sex, as by site and recency of sentinel fracture.

Introduction
The recency of prior fractures affects subsequent fracture risk. Variable recency may obscure other factors that affect subsequent fracture risk. The aim of this study was to quantify the effect of a sentinel fracture by site, age, and sex where the recency was held constant.

Methods
The study used data from the Reykjavik Study fracture register that documented prospectively all fractures at all skeletal sites in a large sample of the population of Iceland. Fracture incidence was compared to that of the general population determined at fixed times after a sentinel fracture (humeral, clinical vertebral, forearm, hip, and minor fractures). Outcome fractures comprised a major osteoporotic fracture and hip fracture.

Results
Sentinel osteoporotic fractures were identified in 9504 men and women. Of these, 3616 individuals sustained a major osteoporotic fracture as the first subsequent fracture, of whom 1799 sustained a hip fracture. Hazard ratios for prior fracture were consistently higher in men than in women and decreased progressively with age. Hazard ratios varied according to the site of sentinel fracture with higher ratios for hip and vertebral fracture than for humerus, forearm, or minor osteoporotic fracture.

Conclusion
The risk of a recurrent fragility fracture varies by age, sex, and site of sentinel fracture when recency is held constant.

Text
Prior Fx v OSIN R2 - Accepted Manuscript
Restricted to Repository staff only until 4 February 2022.
Request a copy

More information

Accepted/In Press date: 16 December 2020
e-pub ahead of print date: 4 February 2021
Keywords: Fracture risk, Prior fracture, Recency of fracture, Risk assessment, Sentinel fracture

Identifiers

Local EPrints ID: 447077
URI: http://eprints.soton.ac.uk/id/eprint/447077
ISSN: 0937-941X
PURE UUID: 8403b2be-17b5-480c-855f-9fd4e64a6c5e
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 02 Mar 2021 17:33
Last modified: 22 Nov 2021 02:50

Export record

Altmetrics

Contributors

Author: J.A, Kanis
Author: H. Johansson
Author: N.C. Harvey ORCID iD
Author: V. Gudnason
Author: G. Sigurdsson
Author: K. Siggeirsdottir
Author: M. Lorentzon
Author: E. Liu
Author: L. Vandenput
Author: E.V. McCloskey

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×