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Combination analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes

Combination analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes
Combination analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes
We examined the associations of gestational diabetes mellitus (GDM) and women’s weight status from pre-pregnancy through post-delivery with the risk of developing dysglycaemia [impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes (T2D)] 4–6 years post-delivery. Using Poisson regression with confounder adjustments, we assessed associations of standard categorisations of prospectively ascertained pre-pregnancy overweight and obesity (OWOB), gestational weight gain (GWG) and substantial post-delivery weight retention (PDWR) with post-delivery dysglycaemia (n = 692). Women with GDM had a higher risk of later T2D [relative risk (95% CI) 12.07 (4.55, 32.02)] and dysglycaemia [3.02 (2.19, 4.16)] compared with non-GDM women. Independent of GDM, women with pre-pregnancy OWOB also had a higher risk of post-delivery dysglycaemia. Women with GDM who were OWOB pre-pregnancy and had subsequent PDWR (≥ 5 kg) had 2.38 times (1.29, 4.41) the risk of post-delivery dysglycaemia compared with pre-pregnancy lean GDM women without PDWR. No consistent associations were observed between GWG and later dysglycaemia risk. In conclusion, women with GDM have a higher risk of T2D 4–6 years after the index pregnancy. Pre-pregnancy OWOB and PDWR exacerbate the risk of post-delivery dysglycaemia. Weight management during preconception and post-delivery represent early windows of opportunity for improving long-term health, especially in those with GDM.
2045-2322
Chen, Ling-Wei
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Soh, Shu-E.
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Tint, Mya Thway
3aaf54db-4dbd-4d6b-90ae-440a18e381ef
Loy, See Ling
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Yap, Fabian
22f6b954-31fc-4696-a52b-e985a424b95b
Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Lee, Yung Seng
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Shek, Lynette Pei-Chi
ff5b44bf-5ab5-4249-8cf1-21751a4f6ae8
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Eriksson, Johan G.
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Chong, Yap-Seng
492de658-aa9e-4b57-95bf-33109f4d2cc5
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Chen, Ling-Wei
528a58c5-d5ec-4dd8-b3c4-0f2f2a97ea53
Soh, Shu-E.
acd6791d-fbf2-4ec7-a1f5-7bb539f44049
Tint, Mya Thway
3aaf54db-4dbd-4d6b-90ae-440a18e381ef
Loy, See Ling
6fd10b64-1de2-419e-a5f4-b505be233e6e
Yap, Fabian
22f6b954-31fc-4696-a52b-e985a424b95b
Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Lee, Yung Seng
0e28a8d6-3085-4086-9fa1-ac0684783bcf
Shek, Lynette Pei-Chi
ff5b44bf-5ab5-4249-8cf1-21751a4f6ae8
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Eriksson, Johan G.
e95e6451-67bb-4338-803e-7af310a920ac
Chong, Yap-Seng
492de658-aa9e-4b57-95bf-33109f4d2cc5
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293

Chen, Ling-Wei, Soh, Shu-E., Tint, Mya Thway, Loy, See Ling, Yap, Fabian, Tan, Kok Hian, Lee, Yung Seng, Shek, Lynette Pei-Chi, Godfrey, Keith, Gluckman, Peter D., Eriksson, Johan G., Chong, Yap-Seng and Chan, Shiao-Yng (2021) Combination analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes. Scientific Reports, 11 (1), [5021]. (doi:10.1038/s41598-021-82789-x).

Record type: Article

Abstract

We examined the associations of gestational diabetes mellitus (GDM) and women’s weight status from pre-pregnancy through post-delivery with the risk of developing dysglycaemia [impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes (T2D)] 4–6 years post-delivery. Using Poisson regression with confounder adjustments, we assessed associations of standard categorisations of prospectively ascertained pre-pregnancy overweight and obesity (OWOB), gestational weight gain (GWG) and substantial post-delivery weight retention (PDWR) with post-delivery dysglycaemia (n = 692). Women with GDM had a higher risk of later T2D [relative risk (95% CI) 12.07 (4.55, 32.02)] and dysglycaemia [3.02 (2.19, 4.16)] compared with non-GDM women. Independent of GDM, women with pre-pregnancy OWOB also had a higher risk of post-delivery dysglycaemia. Women with GDM who were OWOB pre-pregnancy and had subsequent PDWR (≥ 5 kg) had 2.38 times (1.29, 4.41) the risk of post-delivery dysglycaemia compared with pre-pregnancy lean GDM women without PDWR. No consistent associations were observed between GWG and later dysglycaemia risk. In conclusion, women with GDM have a higher risk of T2D 4–6 years after the index pregnancy. Pre-pregnancy OWOB and PDWR exacerbate the risk of post-delivery dysglycaemia. Weight management during preconception and post-delivery represent early windows of opportunity for improving long-term health, especially in those with GDM.

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Accepted/In Press date: 21 January 2021
e-pub ahead of print date: 3 March 2021

Identifiers

Local EPrints ID: 447175
URI: http://eprints.soton.ac.uk/id/eprint/447175
ISSN: 2045-2322
PURE UUID: 8c194f14-f413-4442-a1d4-b73e0eba7e0f
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 04 Mar 2021 17:40
Last modified: 26 Nov 2021 07:19

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Contributors

Author: Ling-Wei Chen
Author: Shu-E. Soh
Author: Mya Thway Tint
Author: See Ling Loy
Author: Fabian Yap
Author: Kok Hian Tan
Author: Yung Seng Lee
Author: Lynette Pei-Chi Shek
Author: Keith Godfrey ORCID iD
Author: Peter D. Gluckman
Author: Johan G. Eriksson
Author: Yap-Seng Chong
Author: Shiao-Yng Chan

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