Children of Asian ethnicity in Australia have higher risk of food allergy and early onset eczema than those in Singapore

Accepted/In Press date: 14 February 2021

e-pub ahead of print date: 22 March 2021

Published date: October 2021

Additional Information: Funding Information: This research was supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore-NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. This work was also supported by the National Medical Research Council, NMRC/CSA/022/2010 and NRF370062-HUJ-NUS (Project 10). Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore. K. M. Godfrey is funded by the UK Medical Research Council (MC_UU_12011/4) and the National Institute for Health Research (NIHR Senior Investigator (NF-SI-0515-10042) and NIHR Southampton Biomedical Research Centre (IS-BRC-1215-20004). E. H. Tham is supported by the National Medical Research Council (NMRC) Research Training Fellowship grant [MH 095:003\008-225] and the Transition Award [MOH-000269] from NMRC, Singapore. The HealthNuts study was funded by the National Health & Medical Research Council (NHMRC) of Australia, Ilhan Food Allergy Foundation and AnaphylaxiStop. Support for research at the Murdoch Children's Research Institute was provided by the Victorian Government's Operational Infrastructure Support Program. N. H. A Suaini received funding from the NHMRC Centre for Food and Allergy Research Drs Suaini, Loo, Peters, Yap, Allen, Bever, Martino, Goh, Dharmage, Colega, Fong, Ponsonby, Tan, Lee, Shek, Koplin and Tham have nothing to disclose. Dr. Tang reports personal fees from Prota Therapeutics, personal fees from Abbott Nutrition, personal fees from Nestle Health Science, personal fees from Bayer Pharmaceuticals, outside the submitted work. Dr. Godfrey reports other from Nestle Nutrition Institute, grants from Nestec, outside the submitted work; in addition, Dr. Godfrey has a patent Phenotype prediction issued, a patent Predictive use of CpG methylation issued, a patent Maternal Nutrition Composition pending, a patent vitamin B6 in maternal administration for the prevention of overweight or obesity in the offspring issued, and a patent Composition and its use pending. The authors acknowledge the contribution of the rest of the GUSTO study group which includes Lee Yung Seng, Wei Wei Pang, Pratibha Agarwal, Dennis Bier, Arijit Biswas, Shirong Cai, Jerry Kok Yen Chan, Cornelia Yin Ing Chee, Helen Y. H. Chen, Audrey Chia, Amutha Chinnadurai, Chai Kiat Chng, Shang Chee Chong, Mei Chien Chua, Chun Ming Ding, Eric Andrew Finkelstein, Doris Fok, Marielle Fortier, Yam Thiam Daniel Goh, Joshua J. Gooley, Wee Meng Han, Mark Hanson, Christiani Jeyakumar Henry, Joanna D. Holbrook, Chin-Ying Hsu, Hazel Inskip, Jeevesh Kapur, Birit Leutscher-Broekman, Sok Bee Lim, Seong Feei Loh, Yen-Ling Low, Iliana Magiati, Lourdes Mary Daniel, Michael Meaney, Susan Morton, Cheryl Ngo, Krishnamoorthy Niduvaje, Anqi Qiu, Boon Long Quah, Victor Samuel Rajadurai, Mary Rauff, Jenny L. Richmond, Anne Rifkin-Graboi, Allan Sheppard, Borys Shuter, Leher Singh, Wing Chee So, Walter Stunkel, Lin Lin Su, Soek Hui Tan, Rob M. van Dam, Sudhakar K. Venkatesh, Inez Bik Yun Wong, P. C. Wong and George Seow Heong Yeo. We would also like to thank the GUSTO Executive committee, research staff and all parents and children who participated in the GUSTO study. The HealthNuts study group is made up of the HealthNuts investigators, including Professor Melissa Wake, A/Prof Adrian Lowe, Professor Lyle Gurrin, Professor Colin Robertson and Professor Terry Dwyer. We thank the parents and children who participated in the HealthNuts Study and the staff of Melbourne?s Local Government Areas for access to community Immunization Clinics. We would also like to thank the HealthNuts safety committee: Associate Professor Noel Cranswick (Australian Paediatric Pharmacology Research Unit, Murdoch Childrens Research Institute), Dr Joanne Smart (Department of Allergy and Immunology, Royal Children?s Hospital, Melbourne, Australia) and Professor Jo Douglass (Director, Department of Allergy and Immunology, Royal Melbourne Hospital, Melbourne, Australia). We thank ALK Abello, S.A. Madrid, Espa?a for providing the allergens for the skin prick tests. We also thank the HealthNuts study research staff: Nicholas Osborne, Megan Mathers, Dean Tey, Marnie Robinson, Giovanni Zurzolo, Leone Thiele, Helen Czech, Deborah Anderson, Carley Garner and John Molloy. Funding Information: This research was supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore‐NMRC/TCR/004‐NUS/2008; NMRC/TCR/012‐NUHS/2014. This work was also supported by the National Medical Research Council, NMRC/CSA/022/2010 and NRF370062‐HUJ‐NUS (Project 10). Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore. K. M. Godfrey is funded by the UK Medical Research Council (MC_UU_12011/4) and the National Institute for Health Research (NIHR Senior Investigator (NF‐SI‐0515‐10042) and NIHR Southampton Biomedical Research Centre (IS‐BRC‐1215‐20004). E. H. Tham is supported by the National Medical Research Council (NMRC) Research Training Fellowship grant [MH 095:003\008‐225] and the Transition Award [MOH‐000269] from NMRC, Singapore. The HealthNuts study was funded by the National Health & Medical Research Council (NHMRC) of Australia, Ilhan Food Allergy Foundation and AnaphylaxiStop. Support for research at the Murdoch Children's Research Institute was provided by the Victorian Government's Operational Infrastructure Support Program. N. H. A Suaini received funding from the NHMRC Centre for Food and Allergy Research Publisher Copyright: © 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Keywords: Asian children, GUSTO, eczema, food allergy, healthnuts

Local EPrints ID: 447237

URI: http://eprints.soton.ac.uk/id/eprint/447237

DOI: doi:10.1111/all.14823

ISSN: 0105-4538

PURE UUID: 60b940ee-01ef-4110-9510-b5373dceee73

ORCID for Keith Godfrey: orcid.org/0000-0002-4643-0618

Date deposited: 05 Mar 2021 17:31

Last modified: 17 Mar 2024 06:21