The synthesis of biologically active indolocarbazole natural products
The synthesis of biologically active indolocarbazole natural products
Covering: up to 2020 The indolocarbazoles, in particular indolo[2,3-a]pyrrolo[3,4-c]carbazole derivatives, are an important class of natural products that exhibit a wide range of biological activities. There has been a plethora of synthetic approaches to this family of natural products, leading to advances in chemical methodology, as well as affording access to molecular scaffolds central to protein kinase drug discovery programmes. In this review, we compile and summarise the synthetic approaches to the indolo[2,3-a]pyrrolo[3,4-c]carbazole derivatives, spanning the period from their isolation in 1980 up to 2020. The selected natural products include indolocarbazoles not functionalised at indolic nitrogen, pyranosylated indolocarbazoles, furanosylated indolocarbazoles and disaccharideindolocarbazoles.
1794-1820
Chambers, George Edward
4690a3c1-2486-4972-a5bb-3e41aa237b95
Sayan, Abdulkadir Emre
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
October 2021
Chambers, George Edward
4690a3c1-2486-4972-a5bb-3e41aa237b95
Sayan, Abdulkadir Emre
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Chambers, George Edward, Sayan, Abdulkadir Emre and Brown, Richard C.D.
(2021)
The synthesis of biologically active indolocarbazole natural products.
Natural Product Reports, 38 (10), .
(doi:10.1039/D0NP00096E).
Abstract
Covering: up to 2020 The indolocarbazoles, in particular indolo[2,3-a]pyrrolo[3,4-c]carbazole derivatives, are an important class of natural products that exhibit a wide range of biological activities. There has been a plethora of synthetic approaches to this family of natural products, leading to advances in chemical methodology, as well as affording access to molecular scaffolds central to protein kinase drug discovery programmes. In this review, we compile and summarise the synthetic approaches to the indolo[2,3-a]pyrrolo[3,4-c]carbazole derivatives, spanning the period from their isolation in 1980 up to 2020. The selected natural products include indolocarbazoles not functionalised at indolic nitrogen, pyranosylated indolocarbazoles, furanosylated indolocarbazoles and disaccharideindolocarbazoles.
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Accepted/In Press date: 16 February 2021
e-pub ahead of print date: 5 March 2021
Published date: October 2021
Additional Information:
Funding Information:
The authors gratefully acknowledge the European France– (Manche)–England cross-border cooperation program INTERREG V A “LABFACT”, co-nanced by ERDF, and EPSRC (EP/R513325/1, DTP Research Studentship for GEC) for nan-cial support.
Publisher Copyright:
© The Royal Society of Chemistry.
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Local EPrints ID: 447532
URI: http://eprints.soton.ac.uk/id/eprint/447532
ISSN: 0265-0568
PURE UUID: 7ecce96a-5453-422e-bed3-d5d28f3d053f
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Date deposited: 15 Mar 2021 17:39
Last modified: 17 Mar 2024 03:22
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Author:
George Edward Chambers
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