The University of Southampton
University of Southampton Institutional Repository

The synthesis of biologically active indolocarbazole natural products

The synthesis of biologically active indolocarbazole natural products
The synthesis of biologically active indolocarbazole natural products

Covering: up to 2020 The indolocarbazoles, in particular indolo[2,3-a]pyrrolo[3,4-c]carbazole derivatives, are an important class of natural products that exhibit a wide range of biological activities. There has been a plethora of synthetic approaches to this family of natural products, leading to advances in chemical methodology, as well as affording access to molecular scaffolds central to protein kinase drug discovery programmes. In this review, we compile and summarise the synthetic approaches to the indolo[2,3-a]pyrrolo[3,4-c]carbazole derivatives, spanning the period from their isolation in 1980 up to 2020. The selected natural products include indolocarbazoles not functionalised at indolic nitrogen, pyranosylated indolocarbazoles, furanosylated indolocarbazoles and disaccharideindolocarbazoles.

0265-0568
1794-1820
Chambers, George Edward
4690a3c1-2486-4972-a5bb-3e41aa237b95
Sayan, Abdulkadir Emre
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Chambers, George Edward
4690a3c1-2486-4972-a5bb-3e41aa237b95
Sayan, Abdulkadir Emre
d1dbbcad-9c53-47c1-8b7e-1b45cc56e077
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5

Chambers, George Edward, Sayan, Abdulkadir Emre and Brown, Richard C.D. (2021) The synthesis of biologically active indolocarbazole natural products. Natural Product Reports, 38 (10), 1794-1820. (doi:10.1039/D0NP00096E).

Record type: Article

Abstract

Covering: up to 2020 The indolocarbazoles, in particular indolo[2,3-a]pyrrolo[3,4-c]carbazole derivatives, are an important class of natural products that exhibit a wide range of biological activities. There has been a plethora of synthetic approaches to this family of natural products, leading to advances in chemical methodology, as well as affording access to molecular scaffolds central to protein kinase drug discovery programmes. In this review, we compile and summarise the synthetic approaches to the indolo[2,3-a]pyrrolo[3,4-c]carbazole derivatives, spanning the period from their isolation in 1980 up to 2020. The selected natural products include indolocarbazoles not functionalised at indolic nitrogen, pyranosylated indolocarbazoles, furanosylated indolocarbazoles and disaccharideindolocarbazoles.

Text
NPR Review (Brown) - Version of Record
Available under License Creative Commons Attribution.
Download (4MB)

More information

Accepted/In Press date: 16 February 2021
e-pub ahead of print date: 5 March 2021
Published date: October 2021
Additional Information: Funding Information: The authors gratefully acknowledge the European France– (Manche)–England cross-border cooperation program INTERREG V A “LABFACT”, co-nanced by ERDF, and EPSRC (EP/R513325/1, DTP Research Studentship for GEC) for nan-cial support. Publisher Copyright: © The Royal Society of Chemistry.

Identifiers

Local EPrints ID: 447532
URI: http://eprints.soton.ac.uk/id/eprint/447532
ISSN: 0265-0568
PURE UUID: 7ecce96a-5453-422e-bed3-d5d28f3d053f
ORCID for Abdulkadir Emre Sayan: ORCID iD orcid.org/0000-0002-5291-1485
ORCID for Richard C.D. Brown: ORCID iD orcid.org/0000-0003-0156-7087

Catalogue record

Date deposited: 15 Mar 2021 17:39
Last modified: 28 Aug 2024 01:44

Export record

Altmetrics

Contributors

Author: George Edward Chambers

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×