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House dust mite sensitization, eczema and wheeze increase risk of shellfish sensitization

House dust mite sensitization, eczema and wheeze increase risk of shellfish sensitization
House dust mite sensitization, eczema and wheeze increase risk of shellfish sensitization
Shellfish allergy is more prevalent in South‐East Asia (~5%1) than in Western populations (e.g. United States ~2‐3%.2). Typically commencing in late childhood, it is the leading cause of anaphylaxis in adolescents and adults in Asia. Cross‐sectional studies have demonstrated a high correlation between shellfish and house dust mite (HDM) sensitization in warm, humid climates and urban environments where HDM are ubiquitous. The major shellfish allergen, tropomyosin, shares ~80% structural homology with HDM tropomyosin, and primary sensitization to dust mite tropomyosin has been hypothesized to induce cross‐sensitization to shellfish.
0905-6157
1096-1099
Loo, Evelyn Xiu-Ling
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Lau, Hui Xing
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Suaini, Noor Hidayatul Aini
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Wong, Lydia Su Yin
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Goh, Anne Eng Neo
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Teoh, Oon Hoe
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van Bever, Hugo
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Shek, Lynette Pei-Chi
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Lee, Bee Wah
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Tan, Kok Hian
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Godfrey, Keith
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Eriksson, Johan Gunnar
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Chong, Yap-Seng
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Tham, Elizabeth Huiwen
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Loo, Evelyn Xiu-Ling
229ed4b9-220f-4d95-a384-eb6529f6d2d6
Lau, Hui Xing
31f26ca2-82af-47d4-9077-84a4ebc19ba8
Suaini, Noor Hidayatul Aini
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Wong, Lydia Su Yin
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Goh, Anne Eng Neo
9d869111-5368-420f-97dc-336f052bef41
Teoh, Oon Hoe
1f6973b2-81c6-4749-bef0-d4f09a7ce738
van Bever, Hugo
967ee912-3ad6-4c7b-ab6c-bb50914ea687
Shek, Lynette Pei-Chi
ff5b44bf-5ab5-4249-8cf1-21751a4f6ae8
Lee, Bee Wah
81ec0089-b824-4835-b908-1fc8e9f62249
Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Eriksson, Johan Gunnar
fda8d951-24b6-4dc0-932f-03d1e853d08b
Chong, Yap-Seng
492de658-aa9e-4b57-95bf-33109f4d2cc5
Tham, Elizabeth Huiwen
e22014ec-8242-478a-aafc-e4177164f814

Loo, Evelyn Xiu-Ling, Lau, Hui Xing, Suaini, Noor Hidayatul Aini, Wong, Lydia Su Yin, Goh, Anne Eng Neo, Teoh, Oon Hoe, van Bever, Hugo, Shek, Lynette Pei-Chi, Lee, Bee Wah, Tan, Kok Hian, Godfrey, Keith, Eriksson, Johan Gunnar, Chong, Yap-Seng and Tham, Elizabeth Huiwen (2021) House dust mite sensitization, eczema and wheeze increase risk of shellfish sensitization. Pediatric Allergy and Immunology, 32 (5), 1096-1099. (doi:10.1111/pai.13493).

Record type: Letter

Abstract

Shellfish allergy is more prevalent in South‐East Asia (~5%1) than in Western populations (e.g. United States ~2‐3%.2). Typically commencing in late childhood, it is the leading cause of anaphylaxis in adolescents and adults in Asia. Cross‐sectional studies have demonstrated a high correlation between shellfish and house dust mite (HDM) sensitization in warm, humid climates and urban environments where HDM are ubiquitous. The major shellfish allergen, tropomyosin, shares ~80% structural homology with HDM tropomyosin, and primary sensitization to dust mite tropomyosin has been hypothesized to induce cross‐sensitization to shellfish.

Text
Shellfish HDM paper revised clean 010221 - Accepted Manuscript
Restricted to Repository staff only until 9 March 2022.
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More information

Accepted/In Press date: 2 March 2021
e-pub ahead of print date: 9 March 2021

Identifiers

Local EPrints ID: 447693
URI: http://eprints.soton.ac.uk/id/eprint/447693
ISSN: 0905-6157
PURE UUID: 549e7d77-1cdc-4326-bcdc-7a6badfa0e90
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 18 Mar 2021 17:46
Last modified: 26 Nov 2021 02:35

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Contributors

Author: Evelyn Xiu-Ling Loo
Author: Hui Xing Lau
Author: Noor Hidayatul Aini Suaini
Author: Lydia Su Yin Wong
Author: Anne Eng Neo Goh
Author: Oon Hoe Teoh
Author: Hugo van Bever
Author: Lynette Pei-Chi Shek
Author: Bee Wah Lee
Author: Kok Hian Tan
Author: Keith Godfrey ORCID iD
Author: Johan Gunnar Eriksson
Author: Yap-Seng Chong
Author: Elizabeth Huiwen Tham

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