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Disorders of vision in neonatal hypoxic-ischaemic encephalopathy: a systematic review

Disorders of vision in neonatal hypoxic-ischaemic encephalopathy: a systematic review
Disorders of vision in neonatal hypoxic-ischaemic encephalopathy: a systematic review
Objective: Neonatal hypoxic-ischaemic encephalopathy (HIE) following perinatal asphyxia in term infants is associated with neonatal mortality and a high risk of neurodevelopmental impairment later in life. Visual disorders are an accepted complication of HIE and the association has been cited in the literature many times. This review aims to study the evidence for this association and assess the quality of the data on which this is based.

Design: A systematic literature review was conducted and 922 citations were assessed using standard methods outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol.

Results: The results demonstrate that the majority of studies have reported on various neurodevelopmental outcomes but rarely specifically vision. Based on limited currently available data, extracted from a number of small studies, an association of neonatal HIE with visual impairments seems to exist but detail is lacking. Notably, in the existing studies, there is a striking lack of consistency in the methods used to diagnose HIE and, similarly, a wide variation in the methods employed to measure visual function.

Conclusions: To explore the observed association further in terms of prognosis and the effects of HIE treatments on visual outcomes, future studies will need to address the issues of standardised diagnostic criteria, severity grading and robust, age-appropriate visual assessment.
1359-2998
F1-F6
Nagy, Eva
9e37d84c-1d52-455a-87c8-c7535915156c
Self, Jay
0f6efc58-ae24-4667-b8d6-6fafa849e389
Williams, Cathy
80d41825-ac47-47c6-bb00-1cb8ce6b7bda
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Nagy, Eva
9e37d84c-1d52-455a-87c8-c7535915156c
Self, Jay
0f6efc58-ae24-4667-b8d6-6fafa849e389
Williams, Cathy
80d41825-ac47-47c6-bb00-1cb8ce6b7bda
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba

Nagy, Eva, Self, Jay, Williams, Cathy and Vollmer, Brigitte (2020) Disorders of vision in neonatal hypoxic-ischaemic encephalopathy: a systematic review. Archives of Disease in Childhood - Fetal and Neonatal Edition, F1-F6. (doi:10.1136/archdischild-2020-318998).

Record type: Article

Abstract

Objective: Neonatal hypoxic-ischaemic encephalopathy (HIE) following perinatal asphyxia in term infants is associated with neonatal mortality and a high risk of neurodevelopmental impairment later in life. Visual disorders are an accepted complication of HIE and the association has been cited in the literature many times. This review aims to study the evidence for this association and assess the quality of the data on which this is based.

Design: A systematic literature review was conducted and 922 citations were assessed using standard methods outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol.

Results: The results demonstrate that the majority of studies have reported on various neurodevelopmental outcomes but rarely specifically vision. Based on limited currently available data, extracted from a number of small studies, an association of neonatal HIE with visual impairments seems to exist but detail is lacking. Notably, in the existing studies, there is a striking lack of consistency in the methods used to diagnose HIE and, similarly, a wide variation in the methods employed to measure visual function.

Conclusions: To explore the observed association further in terms of prognosis and the effects of HIE treatments on visual outcomes, future studies will need to address the issues of standardised diagnostic criteria, severity grading and robust, age-appropriate visual assessment.

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HIE MAIN 13.10.202 - Accepted Manuscript
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Accepted/In Press date: 30 October 2020
e-pub ahead of print date: 27 November 2020

Identifiers

Local EPrints ID: 447719
URI: http://eprints.soton.ac.uk/id/eprint/447719
ISSN: 1359-2998
PURE UUID: 4cae667b-4b5b-4de7-aec3-0cc9f8f432f7
ORCID for Jay Self: ORCID iD orcid.org/0000-0002-1030-9963
ORCID for Brigitte Vollmer: ORCID iD orcid.org/0000-0003-4088-5336

Catalogue record

Date deposited: 18 Mar 2021 17:54
Last modified: 26 Nov 2021 02:56

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Contributors

Author: Eva Nagy
Author: Jay Self ORCID iD
Author: Cathy Williams

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