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The importance of maternal pregnancy vitamin D for offspring bone health - learnings from the MAVIDOS Trial

The importance of maternal pregnancy vitamin D for offspring bone health - learnings from the MAVIDOS Trial
The importance of maternal pregnancy vitamin D for offspring bone health - learnings from the MAVIDOS Trial
Optimisation of skeletal mineralisation in childhood is important to reduce childhood fracture and the long-term risk of osteoporosis and fracture in later life. One approach to achieving this is antenatal vitamin D supplementation. The Maternal Vitamin D Osteoporosis Study is a randomised placebo-controlled trial, the aim of which was to assess the effect of antenatal vitamin D supplementation (1000 IU/day cholecalciferol) on offspring bone mass at birth. The study has since extended the follow up into childhood and diversified to assess demographic, lifestyle and genetic factors that determine the biochemical response to antenatal vitamin D supplementation, and to understand the mechanisms underpinning the effects of vitamin D supplementation on offspring bone development, including epigenetics. The demonstration of positive effects of maternal pregnancy vitamin D supplementation on offspring bone development and the delineation of underlying biological mechanisms inform clinical care and future public-health policies.
Maternal Vitamin D Osteoporosis Study, bone mineral density, bone turnover markers, cholecalciferol, epigenetics, osteoporosis, pregnancy
Moon, Rebecca
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Curtis, Elizabeth
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Woolford, Stephen
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Ashai, Shanze
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Cooper, Cyrus
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Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Moon, Rebecca
954fb3ed-9934-4649-886d-f65944985a6b
Curtis, Elizabeth
12aba0c3-1e9e-49ef-a7e9-3247e649cdd6
Woolford, Stephen
fbecb815-4294-45c2-a735-6c3ac9739b96
Ashai, Shanze
57374c08-ecbb-4304-a4bf-74aac8fb65d8
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145

Moon, Rebecca, Curtis, Elizabeth, Woolford, Stephen, Ashai, Shanze, Cooper, Cyrus and Harvey, Nicholas (2021) The importance of maternal pregnancy vitamin D for offspring bone health - learnings from the MAVIDOS Trial. Therapeutic Advances in Musculoskeletal Disease, 13. (doi:10.1177/1759720X211006979).

Record type: Review

Abstract

Optimisation of skeletal mineralisation in childhood is important to reduce childhood fracture and the long-term risk of osteoporosis and fracture in later life. One approach to achieving this is antenatal vitamin D supplementation. The Maternal Vitamin D Osteoporosis Study is a randomised placebo-controlled trial, the aim of which was to assess the effect of antenatal vitamin D supplementation (1000 IU/day cholecalciferol) on offspring bone mass at birth. The study has since extended the follow up into childhood and diversified to assess demographic, lifestyle and genetic factors that determine the biochemical response to antenatal vitamin D supplementation, and to understand the mechanisms underpinning the effects of vitamin D supplementation on offspring bone development, including epigenetics. The demonstration of positive effects of maternal pregnancy vitamin D supplementation on offspring bone development and the delineation of underlying biological mechanisms inform clinical care and future public-health policies.

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The importance of maternal vitamin D in childhood bone health post review 18022021 - Accepted Manuscript
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Accepted/In Press date: 12 March 2021
Published date: 8 April 2021
Additional Information: Funding Information: We would like to thank the Medical Research Council (UK), National Institute for Health Research, Wellcome Trust, versus Arthritis, Royal Osteoporosis Society Osteoporosis and Bone Research Academy and International Osteoporosis Foundation for supporting this work. We are very grateful to all the members of the MAVIDOS trial group: Elaine Alexander, Nigel K. Arden, Linda Barron, Nicholas J. Bishop, Joanna Cantle, Andrew Carr, Patsy Coakley, Sue Collins, Vanessa Cox, Sarah R. Crozier, Stefania D’Angelo, Valerie Davill, Elaine M. Dennison, Caroline Doré, Richard Eastell, Roger Francis, Robert Fraser, Saurabh V. Gandhi, Keith M. Godfrey, Julia Hammond, Kate Hart, Doreen Hedger, Susan Higginbottom, Tina Horsfall, Hazel M. Inskip, M. Kassim Javaid, Wendy Johnson, Stephen Kennedy, Sue Macey, Pam Mahon, Karen McGill, Brenda Morgan, M. Zulf Mughal, Corinne Nisbet, Aris T. Papageorghiou, Mark Philips, Ann Prentice, David M. Reid, Chris Roberts, Sian Robinson, Inez Schoenmakers, Sarah Standfield, Deborah Symmons, Christine Taylor, Pat Taylor, Suzanne Wood. Publisher Copyright: © The Author(s), 2021.
Keywords: Maternal Vitamin D Osteoporosis Study, bone mineral density, bone turnover markers, cholecalciferol, epigenetics, osteoporosis, pregnancy
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Identifiers

Local EPrints ID: 447848
URI: http://eprints.soton.ac.uk/id/eprint/447848
DOI: doi:10.1177/1759720X211006979
PURE UUID: cd201ee4-6e29-4666-8cde-9e166850768d
ORCID for Elizabeth Curtis: ORCID iD orcid.org/0000-0002-5147-0550
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

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Date deposited: 24 Mar 2021 18:28
Last modified: 18 Mar 2024 03:38

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Contributors

Author: Rebecca Moon
Author: Elizabeth Curtis ORCID iD
Author: Stephen Woolford
Author: Shanze Ashai
Author: Cyrus Cooper ORCID iD
Author: Nicholas Harvey ORCID iD

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