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The importance of maternal pregnancy vitamin D for offspring bone health - learnings from the MAVIDOS Trial

The importance of maternal pregnancy vitamin D for offspring bone health - learnings from the MAVIDOS Trial
The importance of maternal pregnancy vitamin D for offspring bone health - learnings from the MAVIDOS Trial
Optimisation of skeletal mineralisation in childhood is important to reduce childhood fracture and the long-term risk of osteoporosis and fracture in later life. One approach to achieving this is antenatal vitamin D supplementation. The Maternal Vitamin D Osteoporosis Study is a randomised placebo-controlled trial, the aim of which was to assess the effect of antenatal vitamin D supplementation (1000 IU/day cholecalciferol) on offspring bone mass at birth. The study has since extended the follow up into childhood and diversified to assess demographic, lifestyle and genetic factors that determine the biochemical response to antenatal vitamin D supplementation, and to understand the mechanisms underpinning the effects of vitamin D supplementation on offspring bone development, including epigenetics. The demonstration of positive effects of maternal pregnancy vitamin D supplementation on offspring bone development and the delineation of underlying biological mechanisms inform clinical care and future public-health policies.
Maternal Vitamin D Osteoporosis Study, bone mineral density, bone turnover markers, cholecalciferol, epigenetics, osteoporosis, pregnancy
Moon, Rebecca
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Curtis, Elizabeth
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Woolford, Stephen
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Ashai, Shanze
57374c08-ecbb-4304-a4bf-74aac8fb65d8
Cooper, Cyrus
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Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Moon, Rebecca
954fb3ed-9934-4649-886d-f65944985a6b
Curtis, Elizabeth
12aba0c3-1e9e-49ef-a7e9-3247e649cdd6
Woolford, Stephen
fbecb815-4294-45c2-a735-6c3ac9739b96
Ashai, Shanze
57374c08-ecbb-4304-a4bf-74aac8fb65d8
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145

Moon, Rebecca, Curtis, Elizabeth, Woolford, Stephen, Ashai, Shanze, Cooper, Cyrus and Harvey, Nicholas (2021) The importance of maternal pregnancy vitamin D for offspring bone health - learnings from the MAVIDOS Trial. Therapeutic Advances in Musculoskeletal Disease, 13. (doi:10.1177/1759720X211006979).

Record type: Review

Abstract

Optimisation of skeletal mineralisation in childhood is important to reduce childhood fracture and the long-term risk of osteoporosis and fracture in later life. One approach to achieving this is antenatal vitamin D supplementation. The Maternal Vitamin D Osteoporosis Study is a randomised placebo-controlled trial, the aim of which was to assess the effect of antenatal vitamin D supplementation (1000 IU/day cholecalciferol) on offspring bone mass at birth. The study has since extended the follow up into childhood and diversified to assess demographic, lifestyle and genetic factors that determine the biochemical response to antenatal vitamin D supplementation, and to understand the mechanisms underpinning the effects of vitamin D supplementation on offspring bone development, including epigenetics. The demonstration of positive effects of maternal pregnancy vitamin D supplementation on offspring bone development and the delineation of underlying biological mechanisms inform clinical care and future public-health policies.

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The importance of maternal vitamin D in childhood bone health post review 18022021 - Accepted Manuscript
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More information

Accepted/In Press date: 12 March 2021
Published date: 8 April 2021
Keywords: Maternal Vitamin D Osteoporosis Study, bone mineral density, bone turnover markers, cholecalciferol, epigenetics, osteoporosis, pregnancy

Identifiers

Local EPrints ID: 447848
URI: http://eprints.soton.ac.uk/id/eprint/447848
PURE UUID: cd201ee4-6e29-4666-8cde-9e166850768d
ORCID for Elizabeth Curtis: ORCID iD orcid.org/0000-0002-5147-0550
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 24 Mar 2021 18:28
Last modified: 26 Nov 2021 03:09

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Contributors

Author: Rebecca Moon
Author: Stephen Woolford
Author: Shanze Ashai
Author: Cyrus Cooper ORCID iD
Author: Nicholas Harvey ORCID iD

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