Routine abdominal magnetic resonance imaging can determine psoas muscle area in paediatric Crohn's disease and correlates with bioelectrical impedance spectroscopy measures of lean mass
Routine abdominal magnetic resonance imaging can determine psoas muscle area in paediatric Crohn's disease and correlates with bioelectrical impedance spectroscopy measures of lean mass
Background: Paediatric Crohn's disease (CD) has been associated with undernutrition. Accurate and accessible measures of body composition would provide data to personalise nutritional therapy. We assessed feasibility of MRI-derived measures of psoas cross-sectional area (PCSA) in paediatric CD and correlated with anthropometric and bioelectrical impedance spectroscopy (BIS) measures. Methods: MRI small bowel/pelvis images of patients with CD, aged <18 years, were retrieved. Patients with concurrent anthropometric and BIS measurements were eligible for inclusion. The PCSA at L3 was calculated by two assessors and combined. To assess reproducibility of measures we calculated the coefficient of variation (CoV). Age, height-Z-scores, weight-Z-scores and BIS measures were correlated with PCSA. Using normal paediatric data from CT-scans we derived psoas area Z-scores for our cohort. Results: 10 patients were included. Mean age at MRI scan was 14.6 years (11.7–16.3). PCSA was calculated for all MRI scans. There was high reproducibility between measurers, mean CoV 0.099. There was a significant positive correlation between PCSA and BIA-derived fat free mass, Pearson correlation coefficient (PCC) 0.831, p = 0.003. Correlation coefficients for PCSA and Height-for-age Z-score, weight-for-age -Z-score and age were PCC 0.343- p = 0.33, PCC = 0.222- p = 0.54, and PCC 0.6034- p = 0.065, respectively. The mean PCSA Z-score was −1.81, with 70% of the patients having a Z-score < −2.0. Conclusions: These data demonstrate the feasibility of deriving measures of body composition from routine MRI imagine. There was significant positive correlation between PCSA and BIS-derived lean mass. Further studies are required to confirm applicability of normal ranges prior to routine clinical implementation.
Body composition, Crohn's disease, MRI, Nutritional assessment, Pediatrics, Sarcopenia
233-238
Ashton, James
03369017-99b5-40ae-9a43-14c98516f37d
Peiris, Dilane
c935f26a-1e1b-4d15-9047-75ec480f3092
Green, Zachary
927f42a3-e038-493c-b0af-cab62a7f5560
Johnson, Mark J.
63704974-cd2b-4f11-addd-db259fb8f0e0
Marino, Luise
c479400f-9424-4879-9ca6-d81e6351de26
Griffiths, Mark
bb6ddffa-7184-4e1f-a6a3-37729aa85c54
Beattie, R. Mark
9a66af0b-f81c-485c-b01d-519403f0038a
April 2021
Ashton, James
03369017-99b5-40ae-9a43-14c98516f37d
Peiris, Dilane
c935f26a-1e1b-4d15-9047-75ec480f3092
Green, Zachary
927f42a3-e038-493c-b0af-cab62a7f5560
Johnson, Mark J.
63704974-cd2b-4f11-addd-db259fb8f0e0
Marino, Luise
c479400f-9424-4879-9ca6-d81e6351de26
Griffiths, Mark
bb6ddffa-7184-4e1f-a6a3-37729aa85c54
Beattie, R. Mark
9a66af0b-f81c-485c-b01d-519403f0038a
Ashton, James, Peiris, Dilane, Green, Zachary, Johnson, Mark J., Marino, Luise, Griffiths, Mark and Beattie, R. Mark
(2021)
Routine abdominal magnetic resonance imaging can determine psoas muscle area in paediatric Crohn's disease and correlates with bioelectrical impedance spectroscopy measures of lean mass.
Clinical Nutrition, 42, .
(doi:10.1016/j.clnesp.2021.01.031).
Abstract
Background: Paediatric Crohn's disease (CD) has been associated with undernutrition. Accurate and accessible measures of body composition would provide data to personalise nutritional therapy. We assessed feasibility of MRI-derived measures of psoas cross-sectional area (PCSA) in paediatric CD and correlated with anthropometric and bioelectrical impedance spectroscopy (BIS) measures. Methods: MRI small bowel/pelvis images of patients with CD, aged <18 years, were retrieved. Patients with concurrent anthropometric and BIS measurements were eligible for inclusion. The PCSA at L3 was calculated by two assessors and combined. To assess reproducibility of measures we calculated the coefficient of variation (CoV). Age, height-Z-scores, weight-Z-scores and BIS measures were correlated with PCSA. Using normal paediatric data from CT-scans we derived psoas area Z-scores for our cohort. Results: 10 patients were included. Mean age at MRI scan was 14.6 years (11.7–16.3). PCSA was calculated for all MRI scans. There was high reproducibility between measurers, mean CoV 0.099. There was a significant positive correlation between PCSA and BIA-derived fat free mass, Pearson correlation coefficient (PCC) 0.831, p = 0.003. Correlation coefficients for PCSA and Height-for-age Z-score, weight-for-age -Z-score and age were PCC 0.343- p = 0.33, PCC = 0.222- p = 0.54, and PCC 0.6034- p = 0.065, respectively. The mean PCSA Z-score was −1.81, with 70% of the patients having a Z-score < −2.0. Conclusions: These data demonstrate the feasibility of deriving measures of body composition from routine MRI imagine. There was significant positive correlation between PCSA and BIS-derived lean mass. Further studies are required to confirm applicability of normal ranges prior to routine clinical implementation.
Text
Clean_Revision_Routine small bowel MRI
- Accepted Manuscript
More information
Accepted/In Press date: 25 January 2021
e-pub ahead of print date: 13 February 2021
Published date: April 2021
Keywords:
Body composition, Crohn's disease, MRI, Nutritional assessment, Pediatrics, Sarcopenia
Identifiers
Local EPrints ID: 447964
URI: http://eprints.soton.ac.uk/id/eprint/447964
ISSN: 0261-5614
PURE UUID: e6a97338-5199-4952-a0d4-7ba10fbac202
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Date deposited: 29 Mar 2021 16:30
Last modified: 17 Mar 2024 06:26
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Contributors
Author:
Dilane Peiris
Author:
Zachary Green
Author:
Mark J. Johnson
Author:
Luise Marino
Author:
Mark Griffiths
Author:
R. Mark Beattie
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