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Childhood vascular phenotypes have differing associations with pre- and postnatal growth

Childhood vascular phenotypes have differing associations with pre- and postnatal growth
Childhood vascular phenotypes have differing associations with pre- and postnatal growth
Objective: in children aged 8-9 years, we examined the associations of linear and abdominal circumference (AC) growth during critical stages of pre- and post-natal development with six vascular measurements commonly used as early markers of atherosclerosis and later CVD risk. 64

Methods: in 724 children from the UK Southampton Women’s Survey mother-offspring cohort, offspring length/height and AC measurements were collected at ten ages between 11 weeks’ gestation and age 8-9 years. Using residual growth modelling and linear regression, we examined the independent associations between growth and detailed vascular measures made at 8-9 years.

Results: postnatal linear and AC growth were associated with higher childhood systolic blood pressure and carotid-femoral pulse wave velocity, while prenatal growth was not. For example, 1SD faster AC gain between ages three and six years was associated with 2.27 (95%CI: 1.56, 2.98) mmHg higher systolic blood pressure. In contrast, faster AC gain before 19 weeks’ gestation was associated with greater carotid intima media thickness (0.009 mm (0.004, 0.015) per 1SD larger 19 week AC), while later growth was not. We found no strong associations between pre- or post-natal growth and diastolic BP or measures of endothelial function.

Conclusions: higher postnatal linear growth and adiposity gain are related to higher systolic blood pressure and carotid-femoral pulse wave velocity in childhood. In contrast, faster growth in early gestation is associated with greater childhood carotid intima media thickness, perhaps resulting from subtle changes in vascular structure that reflect physiological adaptations rather than subclinical atherosclerosis.
0263-6352
Sletner, Line
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Crozier, Sarah
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Inskip, Hazel
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Godfrey, Keith
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Mahon, Pamela A
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Chiesa, Scott T.
ec13f5db-9caa-4942-b951-a9f003a76253
Charakida, Marietta
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Cooper, Cyrus
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Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Sletner, Line
16435d99-972f-4b1e-8c5e-a10bbd79c322
Crozier, Sarah
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Inskip, Hazel
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Godfrey, Keith
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Mahon, Pamela A
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Chiesa, Scott T.
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Charakida, Marietta
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Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Sletner, Line, Crozier, Sarah, Inskip, Hazel, Godfrey, Keith, Mahon, Pamela A, Chiesa, Scott T., Charakida, Marietta, Cooper, Cyrus and Hanson, Mark (2021) Childhood vascular phenotypes have differing associations with pre- and postnatal growth. Journal of Hypertension. (In Press)

Record type: Article

Abstract

Objective: in children aged 8-9 years, we examined the associations of linear and abdominal circumference (AC) growth during critical stages of pre- and post-natal development with six vascular measurements commonly used as early markers of atherosclerosis and later CVD risk. 64

Methods: in 724 children from the UK Southampton Women’s Survey mother-offspring cohort, offspring length/height and AC measurements were collected at ten ages between 11 weeks’ gestation and age 8-9 years. Using residual growth modelling and linear regression, we examined the independent associations between growth and detailed vascular measures made at 8-9 years.

Results: postnatal linear and AC growth were associated with higher childhood systolic blood pressure and carotid-femoral pulse wave velocity, while prenatal growth was not. For example, 1SD faster AC gain between ages three and six years was associated with 2.27 (95%CI: 1.56, 2.98) mmHg higher systolic blood pressure. In contrast, faster AC gain before 19 weeks’ gestation was associated with greater carotid intima media thickness (0.009 mm (0.004, 0.015) per 1SD larger 19 week AC), while later growth was not. We found no strong associations between pre- or post-natal growth and diastolic BP or measures of endothelial function.

Conclusions: higher postnatal linear growth and adiposity gain are related to higher systolic blood pressure and carotid-femoral pulse wave velocity in childhood. In contrast, faster growth in early gestation is associated with greater childhood carotid intima media thickness, perhaps resulting from subtle changes in vascular structure that reflect physiological adaptations rather than subclinical atherosclerosis.

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SWS_vasc_accepted_22.03.21 - Accepted Manuscript
Restricted to Repository staff only until 22 March 2022.
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Accepted/In Press date: 22 March 2021

Identifiers

Local EPrints ID: 448025
URI: http://eprints.soton.ac.uk/id/eprint/448025
ISSN: 0263-6352
PURE UUID: f4b594e3-014c-4657-9c26-af57dbea5918
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Mark Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 30 Mar 2021 16:34
Last modified: 13 Apr 2021 01:38

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Contributors

Author: Line Sletner
Author: Sarah Crozier ORCID iD
Author: Hazel Inskip ORCID iD
Author: Keith Godfrey ORCID iD
Author: Pamela A Mahon
Author: Scott T. Chiesa
Author: Marietta Charakida
Author: Cyrus Cooper ORCID iD
Author: Mark Hanson ORCID iD

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