The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Nutrition and immunity : lessons for COVID-19

Nutrition and immunity : lessons for COVID-19
Nutrition and immunity : lessons for COVID-19
The role of the immune system is to protect the individual against pathogenic organisms. Nutrition is one of multiple factors that determines the immune response and good nutrition is important in supporting the immune response. Immunity can be impaired in older people, particularly those who are frail, in those living with obesity, in those who are malnourished and in those with low intakes of micronutrients. The immune impairments associated with nutritional inadequacy increase susceptibility to infection and permit infections to become more severe, even fatal. The adverse impact of poor nutrition on the immune system, including its inflammatory component, may be one of the explanations for the higher risk of more severe outcomes from infection with SARS-CoV-2 seen in older people and in those living with obesity. Studies of individual micronutrients including vitamin D and zinc suggest roles in reducing severity of infection with SARS-CoV-2. Good nutrition is also important in promoting a diverse gut microbiota, which in turn supports the immune system. The importance of nutrition in supporting the immune response also applies to assuring robust responses to vaccination. There are many lessons from the study of nutrition and immunity that are relevant for the battle
with SARS-CoV-2.

0954-3007
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6

Calder, Philip (2021) Nutrition and immunity : lessons for COVID-19. European Journal of Clinical Nutrition, 11 (1), [19]. (doi:10.1038/s41387-021-00165-0).

Record type: Review

Abstract

The role of the immune system is to protect the individual against pathogenic organisms. Nutrition is one of multiple factors that determines the immune response and good nutrition is important in supporting the immune response. Immunity can be impaired in older people, particularly those who are frail, in those living with obesity, in those who are malnourished and in those with low intakes of micronutrients. The immune impairments associated with nutritional inadequacy increase susceptibility to infection and permit infections to become more severe, even fatal. The adverse impact of poor nutrition on the immune system, including its inflammatory component, may be one of the explanations for the higher risk of more severe outcomes from infection with SARS-CoV-2 seen in older people and in those living with obesity. Studies of individual micronutrients including vitamin D and zinc suggest roles in reducing severity of infection with SARS-CoV-2. Good nutrition is also important in promoting a diverse gut microbiota, which in turn supports the immune system. The importance of nutrition in supporting the immune response also applies to assuring robust responses to vaccination. There are many lessons from the study of nutrition and immunity that are relevant for the battle
with SARS-CoV-2.

Text
Calder_Nutrition and immunity_EJCN_Finalised - Accepted Manuscript
Restricted to Repository staff only until 23 December 2021.
Request a copy
Text
Calder_EJCN_Table - Accepted Manuscript
Restricted to Repository staff only until 23 December 2021.
Request a copy
Text
Calder_EJCN_Figures - Accepted Manuscript
Restricted to Repository staff only until 23 December 2021.
Request a copy

More information

Accepted/In Press date: 17 May 2021
Published date: 23 June 2021

Identifiers

Local EPrints ID: 449162
URI: http://eprints.soton.ac.uk/id/eprint/449162
ISSN: 0954-3007
PURE UUID: 3fc1bf00-eadc-470d-b9ac-89c69be45a7e
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 18 May 2021 16:33
Last modified: 08 Oct 2021 01:35

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×