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Iodine status of pregnant women with obesity from inner city populations in the United Kingdom

Iodine status of pregnant women with obesity from inner city populations in the United Kingdom
Iodine status of pregnant women with obesity from inner city populations in the United Kingdom
Background/Objectives: Iodine is essential for foetal neurodevelopment and growth. Requirements increase in pregnancy to support increased thyroid hormone synthesis for maternal and foetal requirements, and for foetal transfer. Iodine deficiency in pregnancy is widely reported, and obesity has been associated with sub-optimal thyroid function. We evaluated iodine status and its relation with birthweight in a secondary analysis of pregnant women with obesity from multi-ethnic inner-city settings who participated in the UK Pregnancies Better Eating and Activity trial (UPBEAT). Subjects/Methods: Iodine and creatinine concentrations were evaluated in spot urine samples in the second (15+0-18+6 weeks, n=954) trimester of pregnancy. We assessed iodine status as urinary iodine concentration (UIC) and urinary iodine-to-creatinine ratio (UI/Cr) and applied WHO/UNICEF/IGN population threshold of median UIC >150µg/L for iodine sufficiency. Relationships between iodine status and birthweight were determined using linear and logistic regression with appropriate adjustment, including for maternal BMI and gestational age. Results: Median (IQR) UIC and UI/Cr in the second trimester of pregnancy was 147µg/L (99-257) and 97µg/L (59-165), respectively. An UI/Cr 150μg/g was observed in 70% of women. Compared to women with UI/Cr >150 µg/g, there was a trend for women with UI/Cr <150 µg/g to deliver infants with a lower birthweight (β= -60.0 g; 95% CI -120.9 to -1.01, P=0.05). Conclusions: Iodine status of pregnant women with obesity from this cohort of UK women was suboptimal. Lower iodine status was associated with lower birthweight.
0954-3007
801–808
Farebrother, Jessica
127e57d9-cff9-480b-bad7-2a3253f2b020
Dalrymple, Kathryn V
8ef94198-4e90-44a9-b77d-19d35d013cde
White, Sara L.
7c2d382b-89ff-4535-9f86-b542f0e7d20e
Gill, Carolyn
348f87e1-643b-43fa-af36-01a00012f745
Brockbank, Anna
d2b676af-92e5-4217-a581-5486b40d0742
Lazarus, John H.
76eae546-9960-4846-aabf-de07f75133bd
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Flynn, Angela C.
02bcba40-29da-4e1d-a94e-cc3fac438183
Farebrother, Jessica
127e57d9-cff9-480b-bad7-2a3253f2b020
Dalrymple, Kathryn V
8ef94198-4e90-44a9-b77d-19d35d013cde
White, Sara L.
7c2d382b-89ff-4535-9f86-b542f0e7d20e
Gill, Carolyn
348f87e1-643b-43fa-af36-01a00012f745
Brockbank, Anna
d2b676af-92e5-4217-a581-5486b40d0742
Lazarus, John H.
76eae546-9960-4846-aabf-de07f75133bd
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Flynn, Angela C.
02bcba40-29da-4e1d-a94e-cc3fac438183

Farebrother, Jessica, Dalrymple, Kathryn V, White, Sara L., Gill, Carolyn, Brockbank, Anna, Lazarus, John H., Godfrey, Keith, Poston, Lucilla and Flynn, Angela C. (2020) Iodine status of pregnant women with obesity from inner city populations in the United Kingdom. European Journal of Clinical Nutrition, 801–808. (doi:10.1038/s41430-020-00796-z).

Record type: Article

Abstract

Background/Objectives: Iodine is essential for foetal neurodevelopment and growth. Requirements increase in pregnancy to support increased thyroid hormone synthesis for maternal and foetal requirements, and for foetal transfer. Iodine deficiency in pregnancy is widely reported, and obesity has been associated with sub-optimal thyroid function. We evaluated iodine status and its relation with birthweight in a secondary analysis of pregnant women with obesity from multi-ethnic inner-city settings who participated in the UK Pregnancies Better Eating and Activity trial (UPBEAT). Subjects/Methods: Iodine and creatinine concentrations were evaluated in spot urine samples in the second (15+0-18+6 weeks, n=954) trimester of pregnancy. We assessed iodine status as urinary iodine concentration (UIC) and urinary iodine-to-creatinine ratio (UI/Cr) and applied WHO/UNICEF/IGN population threshold of median UIC >150µg/L for iodine sufficiency. Relationships between iodine status and birthweight were determined using linear and logistic regression with appropriate adjustment, including for maternal BMI and gestational age. Results: Median (IQR) UIC and UI/Cr in the second trimester of pregnancy was 147µg/L (99-257) and 97µg/L (59-165), respectively. An UI/Cr 150μg/g was observed in 70% of women. Compared to women with UI/Cr >150 µg/g, there was a trend for women with UI/Cr <150 µg/g to deliver infants with a lower birthweight (β= -60.0 g; 95% CI -120.9 to -1.01, P=0.05). Conclusions: Iodine status of pregnant women with obesity from this cohort of UK women was suboptimal. Lower iodine status was associated with lower birthweight.

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Accepted/In Press date: 18 September 2020
e-pub ahead of print date: 12 November 2020

Identifiers

Local EPrints ID: 449755
URI: http://eprints.soton.ac.uk/id/eprint/449755
ISSN: 0954-3007
PURE UUID: f322eb10-5800-404b-bbe0-894991e9bd82
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 15 Jun 2021 16:33
Last modified: 26 Nov 2021 02:35

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Contributors

Author: Jessica Farebrother
Author: Kathryn V Dalrymple
Author: Sara L. White
Author: Carolyn Gill
Author: Anna Brockbank
Author: John H. Lazarus
Author: Keith Godfrey ORCID iD
Author: Lucilla Poston
Author: Angela C. Flynn

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