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Brown adipose tissue, adiposity and metabolic profile in preschool children

Brown adipose tissue, adiposity and metabolic profile in preschool children
Brown adipose tissue, adiposity and metabolic profile in preschool children
Context: an inverse relationship between brown adipose tissue (BAT) and obesity has previously been reported in older children and adults, but unknown in young children.

Objective: we investigated the influence of BAT in thermoneutral condition on adiposity and metabolic profile in Asian preschool children.

Design, Setting and Participants: a total of 198 children aged 4.5 years from a prospective birth cohort study, Growing Up in Singapore Towards healthy Outcomes (GUSTO) were successfully studied with water-fat magnetic resonance imaging of the supraclavicular-axillary fat depot (FDSA). Regions within FDSA with fat-signal-fraction between 20% and 80% were considered BAT, and percentage BAT (%BAT), (100*BAT volume/ FDSA volume) was calculated.

Main outcome measures: abdominal adipose tissue compartment volumes, ectopic fat in the soleus muscle and liver, fatty liver index, metabolic syndrome scores and markers of insulin sensitivity.

Results: a one percent unit increase in %BAT was associated with lower body mass index, difference (95%CI), -0.08 (-0.10, -0.06) kg/m 2 and smaller abdominal adipose tissue compartment volumes. Ethnicity and sex modified these associations. In addition, each unit increase in %BAT was associated with lower ectopic fat at 4.5 years in the liver, -0.008 (-0.013, -0.003) %, soleus muscle, -0.003 (-0.006, -0.001) % of water-content and lower fatty liver index at 6 years.

Conclusions: higher %BAT is associated with a more favorable metabolic profile. BAT may thus play a role in the pathophysiology of obesity and related metabolic disorders. The observed ethnic and sex differences imply that the protective effect of BAT may vary among different groups.
0021-972X
Mya, Tint
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Michael, Navin
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Sadananthan, Suresh Anand
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Huang, Jonathan Y.
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Khoo, Chin Meng
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Godfrey, Keith
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Shek, L.P.C.
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Lek, Ngee
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Tan, Kok Hian
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Yap, Fabian
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Velan, Sendhil
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Gluckman, Peter D.
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Chong, Yap-Seng
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Karnani, Neerja
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Chan, Shiao-Yng
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Leow, Melvin Khee-Shing
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Lee, Kuan Jin
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Lee, Yung Seng
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Hu, H.
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Zhang, Cuilin
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Fortier, M.V.
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Eriksson, Johan G.
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Mya, Tint
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Michael, Navin
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Sadananthan, Suresh Anand
41601e35-0034-44a4-b37f-87fc92adfe79
Huang, Jonathan Y.
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Khoo, Chin Meng
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Godfrey, Keith
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Shek, L.P.C.
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Lek, Ngee
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Tan, Kok Hian
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Yap, Fabian
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Velan, Sendhil
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Gluckman, Peter D.
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Chong, Yap-Seng
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Karnani, Neerja
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Chan, Shiao-Yng
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Leow, Melvin Khee-Shing
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Lee, Kuan Jin
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Lee, Yung Seng
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Hu, H.
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Zhang, Cuilin
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Fortier, M.V.
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Eriksson, Johan G.
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Mya, Tint, Michael, Navin, Sadananthan, Suresh Anand, Huang, Jonathan Y., Khoo, Chin Meng, Godfrey, Keith, Shek, L.P.C., Lek, Ngee, Tan, Kok Hian, Yap, Fabian, Velan, Sendhil, Gluckman, Peter D., Chong, Yap-Seng, Karnani, Neerja, Chan, Shiao-Yng, Leow, Melvin Khee-Shing, Lee, Kuan Jin, Lee, Yung Seng, Hu, H., Zhang, Cuilin, Fortier, M.V. and Eriksson, Johan G. (2021) Brown adipose tissue, adiposity and metabolic profile in preschool children. Journal of Clinical Endocrinology & Metabolism. (doi:10.1210/clinem/dgab447).

Record type: Article

Abstract

Context: an inverse relationship between brown adipose tissue (BAT) and obesity has previously been reported in older children and adults, but unknown in young children.

Objective: we investigated the influence of BAT in thermoneutral condition on adiposity and metabolic profile in Asian preschool children.

Design, Setting and Participants: a total of 198 children aged 4.5 years from a prospective birth cohort study, Growing Up in Singapore Towards healthy Outcomes (GUSTO) were successfully studied with water-fat magnetic resonance imaging of the supraclavicular-axillary fat depot (FDSA). Regions within FDSA with fat-signal-fraction between 20% and 80% were considered BAT, and percentage BAT (%BAT), (100*BAT volume/ FDSA volume) was calculated.

Main outcome measures: abdominal adipose tissue compartment volumes, ectopic fat in the soleus muscle and liver, fatty liver index, metabolic syndrome scores and markers of insulin sensitivity.

Results: a one percent unit increase in %BAT was associated with lower body mass index, difference (95%CI), -0.08 (-0.10, -0.06) kg/m 2 and smaller abdominal adipose tissue compartment volumes. Ethnicity and sex modified these associations. In addition, each unit increase in %BAT was associated with lower ectopic fat at 4.5 years in the liver, -0.008 (-0.013, -0.003) %, soleus muscle, -0.003 (-0.006, -0.001) % of water-content and lower fatty liver index at 6 years.

Conclusions: higher %BAT is associated with a more favorable metabolic profile. BAT may thus play a role in the pathophysiology of obesity and related metabolic disorders. The observed ethnic and sex differences imply that the protective effect of BAT may vary among different groups.

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3. Manuscript_Tint et.al_2021-06-11_clean - Accepted Manuscript
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More information

Accepted/In Press date: 15 June 2021
e-pub ahead of print date: 18 June 2021

Identifiers

Local EPrints ID: 449905
URI: http://eprints.soton.ac.uk/id/eprint/449905
ISSN: 0021-972X
PURE UUID: 02e2cbd3-a8c7-4802-900a-0093c668129b
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 24 Jun 2021 16:31
Last modified: 25 Jun 2021 01:33

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Contributors

Author: Tint Mya
Author: Navin Michael
Author: Suresh Anand Sadananthan
Author: Jonathan Y. Huang
Author: Chin Meng Khoo
Author: Keith Godfrey ORCID iD
Author: L.P.C. Shek
Author: Ngee Lek
Author: Kok Hian Tan
Author: Fabian Yap
Author: Sendhil Velan
Author: Peter D. Gluckman
Author: Yap-Seng Chong
Author: Neerja Karnani
Author: Shiao-Yng Chan
Author: Melvin Khee-Shing Leow
Author: Kuan Jin Lee
Author: Yung Seng Lee
Author: H. Hu
Author: Cuilin Zhang
Author: M.V. Fortier
Author: Johan G. Eriksson

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